Selected studies of outcomes associated with individual comorbidities
| Article . | Brief summary . |
|---|---|
| Pulmonary disease | |
| Parimon 200529 | 2852 patients 1990-2001; decreasing FEV1 or DLCo, greater A-a gradient associated with early respiratory failure and overall mortality |
| Parimon 200614 | PAM score; FEV1 < 80% and DLCo <70% associated with increased risk of overall mortality |
| Tran 201130 | 845 adult patients 2005-2009; former or current smoking not associated with higher risk of NRM |
| Shibasaki 201631 | 101 adult patients 2005-2014; Dinakara equation preferred for adjusting DLCo for hemoglobin when compared to Cotes equation |
| Fein 201827 | 875 adult patients 2006-2015; “severe” but not “moderate” pulm disease associated with NRM; significantly worse outcomes in severe pulm disease if conditioned with Flu/Mel |
| Yang 202232 | 923 myeloablative recipients 2015-2018; decreased FEV1/FVC ratio associated with chronic pulmonary GVHD |
| Schierbeck 202333 | 663 adult patients 2012-2019; severe pulmonary disease associated with NRM |
| Penack 20224 | 38 760 patients treated 2010-2016; pulm disease associated with increased NRM risk |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; no significant association between moderate disease and NRM |
| Hermans 202312 | 1861 adult patients receiving PTCy 2010-2018; no association between pulm comorbidity and NRM |
| Alhomoud 202334 | 511 adult patients treated 2013-2020; abnormal chest computed tomograpy findings before transplantation associated with increased NRM and pulm morbidity |
| Hepatic disease | |
| Parimon 200614 | PAM score; ALT >49 but not total bilirubin >1.3 associated with increased risk of overall mortality |
| Barba 201135 | 455 adult patients 1998-2008; elevated bilirubin and GGT associated with 100-day NRM; elevated ALT associated with increased chronic GVHD |
| Fein 201827 | 875 adult patients 2006-2015; “severe” but not “mild” disease associated with worse NRM, especially in patients conditioned with Flu/Treo |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; neither mild nor moderate/severe hepatic disease significantly associated with increased NRM |
| Hermans 202312 | 1861 adult patients receiving PTCy 2010-2018; moderate/severe hepatic disease associated with increased NRM |
| Psychiatric disease | |
| El-Jawahri 201736 | 7433 CIBMTR patients 2008-2012; psychiatric comorbidity associated with overall mortality and severe acute GVHD |
| Solh 202037 | 556 adult patients 2003-2017; increased Transplant Evaluation Rating Scale associated with increased NRM and overall mortality |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; psychiatric disease associated with increased NRM |
| Prior solid malignancy | |
| Fein 201827 | 875 adult patients 2006-2015; prior solid malignancy not associated with increased NRM |
| Portuguese 202338 | 1193 adult patients 2010-2018; prior solid malignancy not associated with NRM or overall survival |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; prior solid malignancy not associated with increased NRM |
| Active infection | |
| Campbell 201539 | 458 patients with respiratory nasal wash collected pretransplant 2005-2010; ≥ 1 respiratory virus in 116 (23%) of adult patients; among asymptomatic patients, no difference in mortality but increased duration of hospitalization |
| Versluys 201840 | 179 pediatric patients who underwent routine BAL 2004-2013; asymptomatic URTI did not progress to lower respiratory tract infections; positive BAL associated with allo-mediated lung syndromes (see also Zinter 2021)47 |
| Ottaviano 202041 | 586 pediatric patients 2007-2016; 12% with positive nasal swab; 53 transplanted with active URTI. Increased NRM among patients with URTI who did not delay transplant, though these were potentially higher-risk patients for other reasons |
| Kim 202242 | 946 adult mostly myeloablative transplants 2010-2016; significantly lower day-100 survival with pretransplant lower respiratory disease including rhinovirus; URTI not significantly associated with NRM |
| Cardiac disease | |
| Qazilbash 200943 | 217 adult patients (25% with LVEF <45%) 2000-2006; no association between decreased LVEF and OS |
| Stillwell 201144 | 1178 adult patients 1999-2009; no association between pretransplantation coronary artery disease and mortality, ICU admission, length of stay, or posttransplant cardiac events |
| Fein 201827 | 875 adult patients 2006-2015; cardiac disease, arrhythmia, and valve disease associated with increased NRM; elevated risk seen in cardiac disease with Flu/Bu4 but not Flu/Bu2 or Flu/Treo conditioning |
| Penack 20224 | 38 760 patients treated 2010-2016; cardiac disease and arrhythmia significantly associated with increased NRM |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; combined cardiac disease (including arrhythmia and valve disease) associated with elevated NRM risk |
| Hermans 202312 | 1861 adult patients receiving PTCy 2010-2018; cardiac disease associated with significantly increased NRM |
| Renal disease | |
| Shouval 201845 | 1217 adult patients treated 2003-2015; eGFR <60 mL/min/1.73 m2 associated with increased NRM |
| Fein 201827 | 875 adult patients 2006-2015; eGFR <60 mL/min/1.73 m2 associated with increased NRM |
| Farhadfar 202146 | 13 305 adult patients ≥40 years 2008-2016 (in two groups); decreased eGFR associated with increased NRM |
| Shouval 202219 | SCI Score; 573 adult patients undergoing CD34+ selected transplant 2008-2018; eGFR <60 and 60-89.9 associated with increased NRM |
| Article . | Brief summary . |
|---|---|
| Pulmonary disease | |
| Parimon 200529 | 2852 patients 1990-2001; decreasing FEV1 or DLCo, greater A-a gradient associated with early respiratory failure and overall mortality |
| Parimon 200614 | PAM score; FEV1 < 80% and DLCo <70% associated with increased risk of overall mortality |
| Tran 201130 | 845 adult patients 2005-2009; former or current smoking not associated with higher risk of NRM |
| Shibasaki 201631 | 101 adult patients 2005-2014; Dinakara equation preferred for adjusting DLCo for hemoglobin when compared to Cotes equation |
| Fein 201827 | 875 adult patients 2006-2015; “severe” but not “moderate” pulm disease associated with NRM; significantly worse outcomes in severe pulm disease if conditioned with Flu/Mel |
| Yang 202232 | 923 myeloablative recipients 2015-2018; decreased FEV1/FVC ratio associated with chronic pulmonary GVHD |
| Schierbeck 202333 | 663 adult patients 2012-2019; severe pulmonary disease associated with NRM |
| Penack 20224 | 38 760 patients treated 2010-2016; pulm disease associated with increased NRM risk |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; no significant association between moderate disease and NRM |
| Hermans 202312 | 1861 adult patients receiving PTCy 2010-2018; no association between pulm comorbidity and NRM |
| Alhomoud 202334 | 511 adult patients treated 2013-2020; abnormal chest computed tomograpy findings before transplantation associated with increased NRM and pulm morbidity |
| Hepatic disease | |
| Parimon 200614 | PAM score; ALT >49 but not total bilirubin >1.3 associated with increased risk of overall mortality |
| Barba 201135 | 455 adult patients 1998-2008; elevated bilirubin and GGT associated with 100-day NRM; elevated ALT associated with increased chronic GVHD |
| Fein 201827 | 875 adult patients 2006-2015; “severe” but not “mild” disease associated with worse NRM, especially in patients conditioned with Flu/Treo |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; neither mild nor moderate/severe hepatic disease significantly associated with increased NRM |
| Hermans 202312 | 1861 adult patients receiving PTCy 2010-2018; moderate/severe hepatic disease associated with increased NRM |
| Psychiatric disease | |
| El-Jawahri 201736 | 7433 CIBMTR patients 2008-2012; psychiatric comorbidity associated with overall mortality and severe acute GVHD |
| Solh 202037 | 556 adult patients 2003-2017; increased Transplant Evaluation Rating Scale associated with increased NRM and overall mortality |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; psychiatric disease associated with increased NRM |
| Prior solid malignancy | |
| Fein 201827 | 875 adult patients 2006-2015; prior solid malignancy not associated with increased NRM |
| Portuguese 202338 | 1193 adult patients 2010-2018; prior solid malignancy not associated with NRM or overall survival |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; prior solid malignancy not associated with increased NRM |
| Active infection | |
| Campbell 201539 | 458 patients with respiratory nasal wash collected pretransplant 2005-2010; ≥ 1 respiratory virus in 116 (23%) of adult patients; among asymptomatic patients, no difference in mortality but increased duration of hospitalization |
| Versluys 201840 | 179 pediatric patients who underwent routine BAL 2004-2013; asymptomatic URTI did not progress to lower respiratory tract infections; positive BAL associated with allo-mediated lung syndromes (see also Zinter 2021)47 |
| Ottaviano 202041 | 586 pediatric patients 2007-2016; 12% with positive nasal swab; 53 transplanted with active URTI. Increased NRM among patients with URTI who did not delay transplant, though these were potentially higher-risk patients for other reasons |
| Kim 202242 | 946 adult mostly myeloablative transplants 2010-2016; significantly lower day-100 survival with pretransplant lower respiratory disease including rhinovirus; URTI not significantly associated with NRM |
| Cardiac disease | |
| Qazilbash 200943 | 217 adult patients (25% with LVEF <45%) 2000-2006; no association between decreased LVEF and OS |
| Stillwell 201144 | 1178 adult patients 1999-2009; no association between pretransplantation coronary artery disease and mortality, ICU admission, length of stay, or posttransplant cardiac events |
| Fein 201827 | 875 adult patients 2006-2015; cardiac disease, arrhythmia, and valve disease associated with increased NRM; elevated risk seen in cardiac disease with Flu/Bu4 but not Flu/Bu2 or Flu/Treo conditioning |
| Penack 20224 | 38 760 patients treated 2010-2016; cardiac disease and arrhythmia significantly associated with increased NRM |
| Fein 20233 | 1663 adults receiving low-conditioning intensity 2008-2018; combined cardiac disease (including arrhythmia and valve disease) associated with elevated NRM risk |
| Hermans 202312 | 1861 adult patients receiving PTCy 2010-2018; cardiac disease associated with significantly increased NRM |
| Renal disease | |
| Shouval 201845 | 1217 adult patients treated 2003-2015; eGFR <60 mL/min/1.73 m2 associated with increased NRM |
| Fein 201827 | 875 adult patients 2006-2015; eGFR <60 mL/min/1.73 m2 associated with increased NRM |
| Farhadfar 202146 | 13 305 adult patients ≥40 years 2008-2016 (in two groups); decreased eGFR associated with increased NRM |
| Shouval 202219 | SCI Score; 573 adult patients undergoing CD34+ selected transplant 2008-2018; eGFR <60 and 60-89.9 associated with increased NRM |
BAL, bronchoalveolar lavage; Bu2, 2 days of Busulfan; Bu4, 4 days of Busulfan; Flu/Mel, Fludarabine/Melphalan; FVC, forced vital capacity; GGT, gamma-glutamyl transferase; Treo, Treosulfan; URTI, upper respiratory tract infection.