Initial treatment of critical bleeding in patients with ITP
Agent . | Mechanism of action . | Onset of effect . | Risks . |
---|---|---|---|
IVIG | Interferes with FcR-mediated opsonization of antibody-coated platelets by macrophages | Hours | Volume overload Headache Fever |
Glucocorticoids | Inhibits macrophage-mediated platelet clearance Decreases IgG production | Days | Elevated blood glucose Hypertension Steroid psychosis |
Platelet transfusions | Immediate supply of platelets | Immediate | Short duration of effect Transfusion reaction Bacterial infection from contaminated products |
Tranexamic acid | Stabilizes hemostatic clots | Immediate | Headache Nausea |
Agent . | Mechanism of action . | Onset of effect . | Risks . |
---|---|---|---|
IVIG | Interferes with FcR-mediated opsonization of antibody-coated platelets by macrophages | Hours | Volume overload Headache Fever |
Glucocorticoids | Inhibits macrophage-mediated platelet clearance Decreases IgG production | Days | Elevated blood glucose Hypertension Steroid psychosis |
Platelet transfusions | Immediate supply of platelets | Immediate | Short duration of effect Transfusion reaction Bacterial infection from contaminated products |
Tranexamic acid | Stabilizes hemostatic clots | Immediate | Headache Nausea |