Table 1.

Common genetic changes in pediatric and adolescent and young adult acute lymphoblastic leukemia

Genetic changePrognostic significanceALL patient population in which genetic change is commonly found
ETV6-RUNX1 Favorable Pediatric 
Hyperdiploidy* Favorable Pediatric 
Philadelphia chromosome-like Unfavorable AYA 
IKZF1 Unfavorable AYA 
BCR-ABL1 Unfavorable AYA 
Hypodiploidy† Unfavorable AYA 
Genetic changePrognostic significanceALL patient population in which genetic change is commonly found
ETV6-RUNX1 Favorable Pediatric 
Hyperdiploidy* Favorable Pediatric 
Philadelphia chromosome-like Unfavorable AYA 
IKZF1 Unfavorable AYA 
BCR-ABL1 Unfavorable AYA 
Hypodiploidy† Unfavorable AYA 
*

Leukemia blasts containing >50 chromosomes.

†

Leukemia blasts containing ≤45 chromosomes.

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