Ongoing trials comparing IV to oral iron for iron deficiency anemia during pregnancy36–40
| Trial . | Location/funding . | Inclusion . | IV iron (1) . | IV iron (2) . | Oral iron . | Masking . | Primary outcome . | N . |
|---|---|---|---|---|---|---|---|---|
| EDIVA39 | Bangladesh Gates | Hb <10 at 13-32 weeks | Ferric carboxymaltose, 1000 mg | - | Ferrous sulfate, 60 mg bid | No | Maternal anemia (Hb <11) at 36 weeks | 900 |
| IVIDA236 | US NIH | Hb <10 & ferritin <30 at 24-28 weeks | Ferric derisomaltose, 1000 mg | - | Ferrous sulfate, 65 mg qd-tid | Yes | Maternal peripartum blood transfusion | 746 |
| IVON37 | Nigeria Gates | Hb <10 at 20-32 weeks | Ferric carboxymaltose, 1000 mg | - | Ferrous sulfate, 65 mg tid | No | Maternal anemia (Hb <11) at 36 weeks | 1056 |
| RAPID IRON38 | India Children Investment Fund Foundation (UK) | Hb <10 at 13-26 weeks | Ferric carboxymaltose, 1000 mg | Ferric derisomaltose, 1000 mg | Ferrous sulfate, 60 mg bid | No | Low birth weight Maternal anemia (Hb <11) at 30-34 weeks | 4320 |
| REVAMP-TT40 | Malawi Gates | Hb <10 at 27-35 weeks | Ferric carboxymaltose, 1000 mg | - | Ferrous sulfate, 60 mg bid | No | Maternal anemia (Hb <11) at 36 weeks | 590 |
| Trial . | Location/funding . | Inclusion . | IV iron (1) . | IV iron (2) . | Oral iron . | Masking . | Primary outcome . | N . |
|---|---|---|---|---|---|---|---|---|
| EDIVA39 | Bangladesh Gates | Hb <10 at 13-32 weeks | Ferric carboxymaltose, 1000 mg | - | Ferrous sulfate, 60 mg bid | No | Maternal anemia (Hb <11) at 36 weeks | 900 |
| IVIDA236 | US NIH | Hb <10 & ferritin <30 at 24-28 weeks | Ferric derisomaltose, 1000 mg | - | Ferrous sulfate, 65 mg qd-tid | Yes | Maternal peripartum blood transfusion | 746 |
| IVON37 | Nigeria Gates | Hb <10 at 20-32 weeks | Ferric carboxymaltose, 1000 mg | - | Ferrous sulfate, 65 mg tid | No | Maternal anemia (Hb <11) at 36 weeks | 1056 |
| RAPID IRON38 | India Children Investment Fund Foundation (UK) | Hb <10 at 13-26 weeks | Ferric carboxymaltose, 1000 mg | Ferric derisomaltose, 1000 mg | Ferrous sulfate, 60 mg bid | No | Low birth weight Maternal anemia (Hb <11) at 30-34 weeks | 4320 |
| REVAMP-TT40 | Malawi Gates | Hb <10 at 27-35 weeks | Ferric carboxymaltose, 1000 mg | - | Ferrous sulfate, 60 mg bid | No | Maternal anemia (Hb <11) at 36 weeks | 590 |