Table 1. Prognostic scoring systems for... | American Society of Hematology

Table 1.

Prognostic scoring systems for myelofibrosis

	DIPSS³	DIPSS plus³⁸	MIPSS70⁷	MIPSS70 plus	MYSEC³⁹
Age	☑	☑	☑	☑	☑
Anemia (hemoglobin <10)	☑	☑	☑	☑	☑
WBC >25	☑	☑	☑
Blast %	☑	☑	☑	☑	☑
Constitutional symptoms	☑	☑	☑	☑	☑
Platelets <100		☑	☑		☑
Red cell transfusion dependent		☑
Unfavorable karyotype^*		☑		☑
Bone marrow fibrosis grade			☑
High-risk molecular mutations (1)			☑	☑
High-risk molecular mutations (≥2)			☑	☑
Type 1 CAL-R absence			☑		☑
Scoring	Low risk: 0	Low: 0	Low: 0-1	Low: 0-2	Low: <11
	Int-1: 1-2	Int-1: 1	Intermediate: 2-4	Intermediate: 3	Int-1: 11-13
	Int-2: 3-4	Int-2: 2-3	High: ≥5	High: 4-6	Int-2: 14-16
	High risk: 5-6	High risk: 4-6		Very high: ≥7	High: >16

	DIPSS³	DIPSS plus³⁸	MIPSS70⁷	MIPSS70 plus	MYSEC³⁹
Age	☑	☑	☑	☑	☑
Anemia (hemoglobin <10)	☑	☑	☑	☑	☑
WBC >25	☑	☑	☑
Blast %	☑	☑	☑	☑	☑
Constitutional symptoms	☑	☑	☑	☑	☑
Platelets <100		☑	☑		☑
Red cell transfusion dependent		☑
Unfavorable karyotype^*		☑		☑
Bone marrow fibrosis grade			☑
High-risk molecular mutations (1)			☑	☑
High-risk molecular mutations (≥2)			☑	☑
Type 1 CAL-R absence			☑		☑
Scoring	Low risk: 0	Low: 0	Low: 0-1	Low: 0-2	Low: <11
	Int-1: 1-2	Int-1: 1	Intermediate: 2-4	Intermediate: 3	Int-1: 11-13
	Int-2: 3-4	Int-2: 2-3	High: ≥5	High: 4-6	Int-2: 14-16
	High risk: 5-6	High risk: 4-6		Very high: ≥7	High: >16

Unfavorable karyotype: Complex karyotype or one or two abnormalities that include +8, –7/7q–, i(17q), –5/5q–, 12p–, inv(3), or 11q23. High-Risk molecular mutations: ASXL1, IDH1/2, EZH2, SRSF2, and U2AF1.

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