Known-group comparisons of the scales and single items of the EORTC QLQ-HL27 at baseline
| EORTC QLQ-HL27 . | On treatment vs after treatment at baseline . | |||||
|---|---|---|---|---|---|---|
| On treatment . | After treatment . | P value . | Difference between means . | Cohen d ES . | ||
| n = 165 . | n = 200 . | |||||
| Mean (SD) . | Mean (SD) . | |||||
| Scales | ||||||
| SB | Symptom burden | 25.7 (20.1) | 18.0 (18.0) | <.01 | −7.7 | 0.40 |
| PC | Physical condition/fatigue | 37.2 (25.8) | 23.2 (23.3) | <.01 | −14.0 | 0.57 |
| EI | Emotional impact | 26.9 (22.0) | 22.1 (23.6) | .04 | −4.8 | 0.21 |
| WH | Worries/fears about health and functioning | 39.8 (26.4) | 37.8 (28.8) | .48 | −2.0 | 0.07 |
| Single items (conditional) | ||||||
| PW | Problems at work/place of study | 23.3 (34.7) | 18.2 (26.0) | .15 | −5.1 | 0.17 |
| WW | Worries about work/study | 28.0 (34.6) | 29.3 (35.4) | .75 | 1.3 | 0.04 |
| CC | Concerns about ability to have children | 28.5 (36.1) | 25.7 (35.1) | .51 | −2.8 | 0.08 |
| ECOG performance status score | ||||||
| 0 | ≥1 | |||||
| EORTC QLQ-HL27 . | On treatment vs after treatment at baseline . | |||||
|---|---|---|---|---|---|---|
| On treatment . | After treatment . | P value . | Difference between means . | Cohen d ES . | ||
| n = 165 . | n = 200 . | |||||
| Mean (SD) . | Mean (SD) . | |||||
| Scales | ||||||
| SB | Symptom burden | 25.7 (20.1) | 18.0 (18.0) | <.01 | −7.7 | 0.40 |
| PC | Physical condition/fatigue | 37.2 (25.8) | 23.2 (23.3) | <.01 | −14.0 | 0.57 |
| EI | Emotional impact | 26.9 (22.0) | 22.1 (23.6) | .04 | −4.8 | 0.21 |
| WH | Worries/fears about health and functioning | 39.8 (26.4) | 37.8 (28.8) | .48 | −2.0 | 0.07 |
| Single items (conditional) | ||||||
| PW | Problems at work/place of study | 23.3 (34.7) | 18.2 (26.0) | .15 | −5.1 | 0.17 |
| WW | Worries about work/study | 28.0 (34.6) | 29.3 (35.4) | .75 | 1.3 | 0.04 |
| CC | Concerns about ability to have children | 28.5 (36.1) | 25.7 (35.1) | .51 | −2.8 | 0.08 |
| ECOG performance status score | ||||||
| 0 | ≥1 | |||||
| EORTC QLQ-HL27 . | n = 230 . | n = 113 . | P value . | Difference between means . | Cohen d ES . | |
|---|---|---|---|---|---|---|
| Mean (SD) . | Mean (SD) . | |||||
| Scales | ||||||
| SB | Symptom burden | 19.3 (18.7) | 29.0 (20.3) | <.01 | 9.7 | 0.50 |
| PC | Physical condition/fatigue | 25.7 (24.0) | 40.6 (25.6) | <.01 | 14.9 | 0.60 |
| EI | Emotional impact | 22.9 (23.4) | 27.6 (21.7) | .08 | 4.7 | 0.21 |
| WH | Worries/fears about health and functioning | 37.6 (27.6) | 43.3 (25.9) | .07 | 5.7 | 0.21 |
| Single items (conditional) | ||||||
| PW | Problems at work/place of study | 15.6 (25.4) | 29.5 (36.8) | <.01 | 13.9 | 0.44 |
| WW | Worries about work/study | 27.1 (34.0) | 31.8 (35.5) | .28 | 4.7 | 0.14 |
| CC | Concerns about ability to have children | 28.0 (36.7) | 26.1 (33.8) | .70 | −1.9 | 0.05 |
| EORTC QLQ-HL27 . | n = 230 . | n = 113 . | P value . | Difference between means . | Cohen d ES . | |
|---|---|---|---|---|---|---|
| Mean (SD) . | Mean (SD) . | |||||
| Scales | ||||||
| SB | Symptom burden | 19.3 (18.7) | 29.0 (20.3) | <.01 | 9.7 | 0.50 |
| PC | Physical condition/fatigue | 25.7 (24.0) | 40.6 (25.6) | <.01 | 14.9 | 0.60 |
| EI | Emotional impact | 22.9 (23.4) | 27.6 (21.7) | .08 | 4.7 | 0.21 |
| WH | Worries/fears about health and functioning | 37.6 (27.6) | 43.3 (25.9) | .07 | 5.7 | 0.21 |
| Single items (conditional) | ||||||
| PW | Problems at work/place of study | 15.6 (25.4) | 29.5 (36.8) | <.01 | 13.9 | 0.44 |
| WW | Worries about work/study | 27.1 (34.0) | 31.8 (35.5) | .28 | 4.7 | 0.14 |
| CC | Concerns about ability to have children | 28.0 (36.7) | 26.1 (33.8) | .70 | −1.9 | 0.05 |
An ES of 0.2 is considered small; 0.5, moderate; and 0.8, large.42