Change in the liver and spleen iron concentration, volume, and content
| . | BELIEVE study + extension . | BEYOND study + extension . | ||||
|---|---|---|---|---|---|---|
| Starting (± StD) . | Δ (± StE) . | P . | Starting (± StD) . | Δ (± StE) . | P . | |
| Spleen iron conc (mg/g) | 10.8 ± 15.6 | −4.9 ± 3.4 | .18 | 2.0 ± 0.9 | −0.4 ± 0.2 | .18 |
| Spleen volume (mL) | 672 ± 242 | −41 ± 67 | .42 | 678 ± 266 | 7 ± 76 | .93 |
| Spleen iron content (g) | 1.97 ± 3.11 | −1.09 ± 0.75 | .18 | 0.29 ± 0.14 | −0.07 ± 0.07 | .40 |
| LIC (mg/g) | 12.7 ± 14.0 | 0.1 ± 4.9 | .99 | 6.2 ± 6.7 | 0.3 ± 0.5 | .63 |
| Liver volume (mL) | 1822 ± 400 | 13 ± 97 | .90 | 1677 ± 497 | 10 ± 32 | .78 |
| Liver iron content (g) | 6.05 ± 7.53 | −0.02 ± 2.75 | .99 | 3.00 ± 3.92 | −0.01 ± 0.29 | .97 |
| Spleen/liver content (%) | 21 ± 20 | −4 ± 5 | .43 | 28 ± 10 | −10 ± 7 | .28 |
| Ferritin (ng/mL) | 2176 ± 2060 | −394 ± 615 | .54 | 659 ± 289 | 154 ± 184 | .56 |
| TIBC (μg/dL) | 396 ± 125 | 90 ± 63 | .19 | 245 ± 15 | 3 ± 11 | .83 |
| Transferrin sat (%) | 61 ± 18 | 1.6 ± 9.1 | .87 | 48 ± 28 | −7.5 ± 7.5 | .50 |
| . | BELIEVE study + extension . | BEYOND study + extension . | ||||
|---|---|---|---|---|---|---|
| Starting (± StD) . | Δ (± StE) . | P . | Starting (± StD) . | Δ (± StE) . | P . | |
| Spleen iron conc (mg/g) | 10.8 ± 15.6 | −4.9 ± 3.4 | .18 | 2.0 ± 0.9 | −0.4 ± 0.2 | .18 |
| Spleen volume (mL) | 672 ± 242 | −41 ± 67 | .42 | 678 ± 266 | 7 ± 76 | .93 |
| Spleen iron content (g) | 1.97 ± 3.11 | −1.09 ± 0.75 | .18 | 0.29 ± 0.14 | −0.07 ± 0.07 | .40 |
| LIC (mg/g) | 12.7 ± 14.0 | 0.1 ± 4.9 | .99 | 6.2 ± 6.7 | 0.3 ± 0.5 | .63 |
| Liver volume (mL) | 1822 ± 400 | 13 ± 97 | .90 | 1677 ± 497 | 10 ± 32 | .78 |
| Liver iron content (g) | 6.05 ± 7.53 | −0.02 ± 2.75 | .99 | 3.00 ± 3.92 | −0.01 ± 0.29 | .97 |
| Spleen/liver content (%) | 21 ± 20 | −4 ± 5 | .43 | 28 ± 10 | −10 ± 7 | .28 |
| Ferritin (ng/mL) | 2176 ± 2060 | −394 ± 615 | .54 | 659 ± 289 | 154 ± 184 | .56 |
| TIBC (μg/dL) | 396 ± 125 | 90 ± 63 | .19 | 245 ± 15 | 3 ± 11 | .83 |
| Transferrin sat (%) | 61 ± 18 | 1.6 ± 9.1 | .87 | 48 ± 28 | −7.5 ± 7.5 | .50 |
Conc, concentration; sat, saturation; StD, standard deviation; StE, standard error.