Summary of responders with baseline disease characteristics
| Baseline value . | Responder (N = 10) . | Nonresponder (N = 101) . | Overall (N = 111) . |
|---|---|---|---|
| Blast percent in blood at baseline | |||
| n | 10 | 94 | 104 |
| Median (min, max) | 0.00 (0.0, 25.0) | 14.50 (0.0, 95.0) | 11.00 (0.0, 95.0) |
| Blast percent in bone marrow at baseline | |||
| n | 10 | 101 | 111 |
| Median (min, max) | 9.50 (4.0, 25.0) | 40.00 (1.8, 95.0) | 34.00 (1.8, 95.0) |
| PD-1 expression on CD8 cells in blood at baseline | |||
| n | 6 | 55 | 61 |
| Median | 25.25 (6.8, 71.4) | 37.80 (6.4, 95.6) | 36.50 (6.4, 95.6) |
| PD-1 expression on CD8 cells in the bone marrow at baseline | |||
| n | 2 | 20 | 22 |
| Median (min, max) | 34.65 (32.5, 36.8) | 42.60 (9.9, 82.5) | 41.30 (9.9, 82.5) |
| PD-1 expression on CD4 cells in the blood at baseline | |||
| n | 6 | 55 | 61 |
| Median (min, max) | 18.35 (7.7, 38.8) | 39.40 (11.5, 88.4) | 36.90 (7.7, 88.4) |
| PD-1 expression on CD4 cells in the bone marrow at baseline | |||
| n | 2 | 20 | 22 |
| Median (min, max) | 25.15 (18.2, 32.1) | 39.20 (15.9, 91.8) | 37.00 (15.9, 91.8) |
| Baseline value . | Responder (N = 10) . | Nonresponder (N = 101) . | Overall (N = 111) . |
|---|---|---|---|
| Blast percent in blood at baseline | |||
| n | 10 | 94 | 104 |
| Median (min, max) | 0.00 (0.0, 25.0) | 14.50 (0.0, 95.0) | 11.00 (0.0, 95.0) |
| Blast percent in bone marrow at baseline | |||
| n | 10 | 101 | 111 |
| Median (min, max) | 9.50 (4.0, 25.0) | 40.00 (1.8, 95.0) | 34.00 (1.8, 95.0) |
| PD-1 expression on CD8 cells in blood at baseline | |||
| n | 6 | 55 | 61 |
| Median | 25.25 (6.8, 71.4) | 37.80 (6.4, 95.6) | 36.50 (6.4, 95.6) |
| PD-1 expression on CD8 cells in the bone marrow at baseline | |||
| n | 2 | 20 | 22 |
| Median (min, max) | 34.65 (32.5, 36.8) | 42.60 (9.9, 82.5) | 41.30 (9.9, 82.5) |
| PD-1 expression on CD4 cells in the blood at baseline | |||
| n | 6 | 55 | 61 |
| Median (min, max) | 18.35 (7.7, 38.8) | 39.40 (11.5, 88.4) | 36.90 (7.7, 88.4) |
| PD-1 expression on CD4 cells in the bone marrow at baseline | |||
| n | 2 | 20 | 22 |
| Median (min, max) | 25.15 (18.2, 32.1) | 39.20 (15.9, 91.8) | 37.00 (15.9, 91.8) |
Baseline is defined as the last assessment that is nonmissing before first dose of vibecotamab.
max, maximum; min, minimum; SD, standard deviation.