Demographic and descriptive data of study participants
| Parameter . | Controls (n = 23) . | SCD (n = 53) . |
|---|---|---|
| Age, y, median (range) | 28 (19-54) | 33.3 (19.1-59.4) |
| Gender | 16 female, 7 male | 27 female, 26 male |
| Hematocrit (%) | 39 (34-45) | 27.5 (19.5-34.4)∗∗∗∗ |
| Hb (g/dL) | 13 (10.8-14.8) | 9.4 (6.5-11.5)∗∗∗∗ |
| MCV (fL) | 89 (80.8-97.0) | 98.5 (69-122)∗ |
| Platelet (109/μL) | 253 (167-352) | 329 (191-695)∗∗ |
| White blood cells (103/μL) | 5.4 (3.2-8.5) | 8.75 (7.1-11.9)∗∗∗∗ |
| TAT complexes (ng/mL) | 1.44 (0.02-8.80) | 8.13 (0.16-32.00)∗∗∗ |
| D-dimer (ng/mL) | 226.2 (43.7-1347.0) | 1865 (213.5-7659.0)∗∗∗∗ |
| HU (%) | 0 | 79 (42/53) |
| Parameter . | Controls (n = 23) . | SCD (n = 53) . |
|---|---|---|
| Age, y, median (range) | 28 (19-54) | 33.3 (19.1-59.4) |
| Gender | 16 female, 7 male | 27 female, 26 male |
| Hematocrit (%) | 39 (34-45) | 27.5 (19.5-34.4)∗∗∗∗ |
| Hb (g/dL) | 13 (10.8-14.8) | 9.4 (6.5-11.5)∗∗∗∗ |
| MCV (fL) | 89 (80.8-97.0) | 98.5 (69-122)∗ |
| Platelet (109/μL) | 253 (167-352) | 329 (191-695)∗∗ |
| White blood cells (103/μL) | 5.4 (3.2-8.5) | 8.75 (7.1-11.9)∗∗∗∗ |
| TAT complexes (ng/mL) | 1.44 (0.02-8.80) | 8.13 (0.16-32.00)∗∗∗ |
| D-dimer (ng/mL) | 226.2 (43.7-1347.0) | 1865 (213.5-7659.0)∗∗∗∗ |
| HU (%) | 0 | 79 (42/53) |
HU, hydroxyurea; MCV, mean corpuscular volume.
∗P < .05, ∗∗P < .01, ∗∗∗P < .001, ∗∗∗∗P < .0001 vs control samples by unpaired Student t test. These cohorts were previously described.21