Univariate and multivariate analyses for PFS and OS
| Variable . | Univariate analysis . | Multivariate analysis . | ||||||
|---|---|---|---|---|---|---|---|---|
| PFS (n = 1860) . | OS (n = 1721 ) . | PFS (n = 1860) . | OS (n = 1721) . | |||||
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Age | 1.0 (1.0-1.0) | <.0001 | 1.0 (1.0-1.0) | <.0001 | ||||
| High-dose melphalan | 1.7 (1.6-1.9) | <.0001 | 1.6 (1.4-1.) | <.0001 | ||||
| ISS II vs I | 1.4 (1.3-1.6) | <.0001 | 1.9 (1.5-2.4) | <.0001 | 1.2 (1.1-1.4) | .0016 | 1.5 (1.2-1.8) | .001 |
| ISS III vs I | 2.0 (1.7-2.3) | <.0001 | 2.9 (2.3-3.6) | <.0001 | 1.7 (1.5-2.0) | <.0001 | 2.1 (1.6-2.6) | <.0001 |
| del(1p32) | 1.5 (1.2-1.7) | <.0001 | 2.5 (2.0-3.1) | <.0001 | 1.3 (1.1-1.5) | .0065 | 1.9 (1.5-2.40) | <.0001 |
| del(17p) | 1.9 (1.6-2.2) | <.0001 | 3.2 (2.6-3.9) | <.0001 | 1.8 (1.5-2.1) | <.0001 | 2.9 (2.3-3.8) | <.0001 |
| t(4;14) | 1.6 (1.4-1.8) | <.0001 | 2.2 (1.8-2.7) | <.0001 | 1.4 (1.2-1.7) | <.0001 | 1.7 (1.4-2.2) | <.0001 |
| Gain(1q) | 1.5 (1.3-1.6) | <.0001 | 1.9 (1.7-2.3) | <.0001 | 1.3 (1.2-1.5) | <.0001 | 1.6 (1.3-1.9) | <.0001 |
| Variable . | Univariate analysis . | Multivariate analysis . | ||||||
|---|---|---|---|---|---|---|---|---|
| PFS (n = 1860) . | OS (n = 1721 ) . | PFS (n = 1860) . | OS (n = 1721) . | |||||
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Age | 1.0 (1.0-1.0) | <.0001 | 1.0 (1.0-1.0) | <.0001 | ||||
| High-dose melphalan | 1.7 (1.6-1.9) | <.0001 | 1.6 (1.4-1.) | <.0001 | ||||
| ISS II vs I | 1.4 (1.3-1.6) | <.0001 | 1.9 (1.5-2.4) | <.0001 | 1.2 (1.1-1.4) | .0016 | 1.5 (1.2-1.8) | .001 |
| ISS III vs I | 2.0 (1.7-2.3) | <.0001 | 2.9 (2.3-3.6) | <.0001 | 1.7 (1.5-2.0) | <.0001 | 2.1 (1.6-2.6) | <.0001 |
| del(1p32) | 1.5 (1.2-1.7) | <.0001 | 2.5 (2.0-3.1) | <.0001 | 1.3 (1.1-1.5) | .0065 | 1.9 (1.5-2.40) | <.0001 |
| del(17p) | 1.9 (1.6-2.2) | <.0001 | 3.2 (2.6-3.9) | <.0001 | 1.8 (1.5-2.1) | <.0001 | 2.9 (2.3-3.8) | <.0001 |
| t(4;14) | 1.6 (1.4-1.8) | <.0001 | 2.2 (1.8-2.7) | <.0001 | 1.4 (1.2-1.7) | <.0001 | 1.7 (1.4-2.2) | <.0001 |
| Gain(1q) | 1.5 (1.3-1.6) | <.0001 | 1.9 (1.7-2.3) | <.0001 | 1.3 (1.2-1.5) | <.0001 | 1.6 (1.3-1.9) | <.0001 |
CI, confidence interval; HR, hazard ratio; OS, overall survival; PFS, progression-free survival.