Histopathologic features of GVHD
| Involved organ . | Features associated with GVHD . |
|---|---|
| Skin | Basal vacuolar changes, dyskeratosis, apoptosis; lymphocytic infiltration38 |
| Oral mucosa | Ulcerations, dyskeratotic epithelium with atypia, acute and chronic inflammatory infiltrate in lamina propria5 |
| GI tract | Epithelial or crypt apoptosis, glandular destruction, lymphocytic infiltrate6 |
| Liver∗ | Interlobular bile duct damage with dilatation, flattening and vacuolization of epithelium, intraepithelial lymphocytic infiltration without features of portal inflammation, apoptotic cells, canalicular cholestasis within lobules6 |
| Bone marrow | Morphology: hypocellular marrow without dysplasia, lymphocytic infiltrate39, Flow cytometry: Severe myelosuppression with absent myelopoiesis, lymphocytic infiltrate39 Cytogenetics: partial or full donor karyotype39 Chimerism: lymphocytes of donor origin |
| Involved organ . | Features associated with GVHD . |
|---|---|
| Skin | Basal vacuolar changes, dyskeratosis, apoptosis; lymphocytic infiltration38 |
| Oral mucosa | Ulcerations, dyskeratotic epithelium with atypia, acute and chronic inflammatory infiltrate in lamina propria5 |
| GI tract | Epithelial or crypt apoptosis, glandular destruction, lymphocytic infiltrate6 |
| Liver∗ | Interlobular bile duct damage with dilatation, flattening and vacuolization of epithelium, intraepithelial lymphocytic infiltration without features of portal inflammation, apoptotic cells, canalicular cholestasis within lobules6 |
| Bone marrow | Morphology: hypocellular marrow without dysplasia, lymphocytic infiltrate39, Flow cytometry: Severe myelosuppression with absent myelopoiesis, lymphocytic infiltrate39 Cytogenetics: partial or full donor karyotype39 Chimerism: lymphocytes of donor origin |
For recipients who retain their native liver, such as after intestinal transplantation.