Cellular platelet functions mediating inflammatory bleeding
| Functions and phenotypes . | Models with aggravated bleeding upon inhibition . | No bleeding observed upon inhibition . | Reference . |
|---|---|---|---|
| Migration | Acute lung injury, cremaster muscle inflammation | rpA | 53,68,87 |
| Degranulation/secretion | Cerebral IRI (tMCAO) in Unc13d−/−Nbeal2−/− DKO mice, tumor bleeding | Acute lung injury, rpA, cerebral IRI (single Unc13d−/− or single Nbeal2−/− KO mice) | 39,44,88,89 |
| PA | Acute lung injury, LPS-induced peritonitis | — | 68 |
| Plasmatic coagulation | Acute lung injury (anti-FIIa, anti-FXa) | — | 68 |
| Lamellipodium formation | — | Acute lung injury, rpA | 53,79 |
| Thrombocytopenia (<10%) | Acute lung injury, cremaster muscle inflammation, cerebral IRI [tMCAO], tumor bleeding, glomerulonephritis, rpA, increased skin permeability even in the absence of inflammation | Autoimmune arthritis | 31,32,35,36,39,42-44,49,50,53,65,67,68,79 |
| Functions and phenotypes . | Models with aggravated bleeding upon inhibition . | No bleeding observed upon inhibition . | Reference . |
|---|---|---|---|
| Migration | Acute lung injury, cremaster muscle inflammation | rpA | 53,68,87 |
| Degranulation/secretion | Cerebral IRI (tMCAO) in Unc13d−/−Nbeal2−/− DKO mice, tumor bleeding | Acute lung injury, rpA, cerebral IRI (single Unc13d−/− or single Nbeal2−/− KO mice) | 39,44,88,89 |
| PA | Acute lung injury, LPS-induced peritonitis | — | 68 |
| Plasmatic coagulation | Acute lung injury (anti-FIIa, anti-FXa) | — | 68 |
| Lamellipodium formation | — | Acute lung injury, rpA | 53,79 |
| Thrombocytopenia (<10%) | Acute lung injury, cremaster muscle inflammation, cerebral IRI [tMCAO], tumor bleeding, glomerulonephritis, rpA, increased skin permeability even in the absence of inflammation | Autoimmune arthritis | 31,32,35,36,39,42-44,49,50,53,65,67,68,79 |