Hematological and extrahematological grade greater than or equal to 3 AEs
| . | Grade 3 . | Grade 4 . | Grade 5 . | |||
|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | |
| Any hematological toxicity | 27 | 11 | — | |||
| Anemia | 2 | 3.1 | — | — | ||
| Neutropenia | 21 | 32.3 | 9 | 13.8 | — | |
| Thrombocytopenia | 4 | 6.2 | 2 | 3.1 | — | |
| Any extrahematological toxicity | 41 | 4 | 5 | |||
| Respiratory/thoracic and mediastinal disorders | 5 | 10.0 | 1 | 2.0 | 1 | 2.0 |
| General disorders/administration site conditions | 6 | 12.0 | 1 | 2.0 | — | |
| Skin and subcutaneous tissue disorders | 6 | 12.0 | 1 | 2.0 | — | |
| Cardiac disorders | 5 | 10.0 | — | 1 | 2.0 | |
| Vascular disorders | 3 | 6.0 | — | 3 | 6.0 | |
| Infections | 3 | 6.0 | 1 | 2.0 | — | |
| Gastrointestinal disorders | 3 | 6.0 | — | — | ||
| Nervous system disorders | 3 | 6.0 | — | — | ||
| Investigations | 1 | 2.0 | — | — | ||
| Metabolism and nutrition disorders | 2 | 4.0 | — | — | ||
| Musculoskeletal and connective tissue disorders | 2 | 4.0 | — | — | ||
| Neoplasms benign/malignant/unspecified | 1 | 2.0 | — | — | ||
| Psychiatric disorders | 1 | 2.0 | — | — | ||
| . | Grade 3 . | Grade 4 . | Grade 5 . | |||
|---|---|---|---|---|---|---|
| n . | % . | n . | % . | n . | % . | |
| Any hematological toxicity | 27 | 11 | — | |||
| Anemia | 2 | 3.1 | — | — | ||
| Neutropenia | 21 | 32.3 | 9 | 13.8 | — | |
| Thrombocytopenia | 4 | 6.2 | 2 | 3.1 | — | |
| Any extrahematological toxicity | 41 | 4 | 5 | |||
| Respiratory/thoracic and mediastinal disorders | 5 | 10.0 | 1 | 2.0 | 1 | 2.0 |
| General disorders/administration site conditions | 6 | 12.0 | 1 | 2.0 | — | |
| Skin and subcutaneous tissue disorders | 6 | 12.0 | 1 | 2.0 | — | |
| Cardiac disorders | 5 | 10.0 | — | 1 | 2.0 | |
| Vascular disorders | 3 | 6.0 | — | 3 | 6.0 | |
| Infections | 3 | 6.0 | 1 | 2.0 | — | |
| Gastrointestinal disorders | 3 | 6.0 | — | — | ||
| Nervous system disorders | 3 | 6.0 | — | — | ||
| Investigations | 1 | 2.0 | — | — | ||
| Metabolism and nutrition disorders | 2 | 4.0 | — | — | ||
| Musculoskeletal and connective tissue disorders | 2 | 4.0 | — | — | ||
| Neoplasms benign/malignant/unspecified | 1 | 2.0 | — | — | ||
| Psychiatric disorders | 1 | 2.0 | — | — | ||
Hematological toxicity values and percentages refer to the 38 events recorded in the total population of 65 patients. Extrahematological toxicity values and percentages refer to the 50 events recorded in 34 patients (1 patient may have experienced more than 1 grade ≥3 AE). The percentages may not correspond to 100% because of rounding.