Definitions of E-lesions in different classification systems
| Year . | Classification . | Reference . | Definition of E-lesions . |
|---|---|---|---|
| 1966 | Rye classification | 7 | E-lesions undefined |
| Involvement of tissue outside of the lymphatic system considered stage IV disease | |||
| 1971 | Ann Arbor classification | 9 | Stage IE: a single extralymphatic organ or site |
| Stage IIE: localized involvement of extralymphatic organ or site and ≥1 lymph node regions on 1 side of the diaphragm | |||
| Stage IIIE: involvement of lymph node regions on both sides of the diaphragm with localized involvement of extralymphatic organ or site | |||
| Examples: multiple nodules in the lung limited to 1 lobe or perihilar extension associated with ipsilateral hilar adenopathy; unilateral pleural effusion with or without lung involvement but with hilar adenopathy | |||
| Liver involvement is considered stage IV/diffuse disease | |||
| 1989 | Cotswolds modification of Ann Arbor classification | 10 | Involvement of extralymphatic tissue on 1 side of the diaphragm by limited direct extension from an adjacent nodal site (ie, extranodal extension) with implicit expectation of prognosis equivalent to that for treatment of nodal disease of same anatomical extent |
| May also include a discrete single extranodal deposit consistent with extension from a regionally involved node | |||
| A single extralymphatic site as the only site of disease should be classified as stage IE; multiple extranodal deposits not included | |||
| Anterior extension of a mediastinal mass into the sternum or chest wall or extension to lung or pericardium should be recorded as extranodal extension | |||
| Extensive extranodal disease is designated stage IV | |||
| 2011 | ICML staging Lugano criteria | 14 | Stage IE: single extranodal lesion without nodal involvement |
| Stage IIE: stage I or II by nodal extent with limited contiguous extranodal involvement | |||
| Stage IIx, stage III, and stage IV: not applicable |
| Year . | Classification . | Reference . | Definition of E-lesions . |
|---|---|---|---|
| 1966 | Rye classification | 7 | E-lesions undefined |
| Involvement of tissue outside of the lymphatic system considered stage IV disease | |||
| 1971 | Ann Arbor classification | 9 | Stage IE: a single extralymphatic organ or site |
| Stage IIE: localized involvement of extralymphatic organ or site and ≥1 lymph node regions on 1 side of the diaphragm | |||
| Stage IIIE: involvement of lymph node regions on both sides of the diaphragm with localized involvement of extralymphatic organ or site | |||
| Examples: multiple nodules in the lung limited to 1 lobe or perihilar extension associated with ipsilateral hilar adenopathy; unilateral pleural effusion with or without lung involvement but with hilar adenopathy | |||
| Liver involvement is considered stage IV/diffuse disease | |||
| 1989 | Cotswolds modification of Ann Arbor classification | 10 | Involvement of extralymphatic tissue on 1 side of the diaphragm by limited direct extension from an adjacent nodal site (ie, extranodal extension) with implicit expectation of prognosis equivalent to that for treatment of nodal disease of same anatomical extent |
| May also include a discrete single extranodal deposit consistent with extension from a regionally involved node | |||
| A single extralymphatic site as the only site of disease should be classified as stage IE; multiple extranodal deposits not included | |||
| Anterior extension of a mediastinal mass into the sternum or chest wall or extension to lung or pericardium should be recorded as extranodal extension | |||
| Extensive extranodal disease is designated stage IV | |||
| 2011 | ICML staging Lugano criteria | 14 | Stage IE: single extranodal lesion without nodal involvement |
| Stage IIE: stage I or II by nodal extent with limited contiguous extranodal involvement | |||
| Stage IIx, stage III, and stage IV: not applicable |
ICML, International Conference on Malignant Melanoma.