Statistical analysis of CD4 and T-LGLL apoptotic response to BNZ-1
| . | 1-month treatment . | Extended treatment . | Washout . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Predose . | D 2 . | D 8 . | D 15 . | D 29 . | Wk 9 . | Wk 13 . | Wk 17 . | Follow-up wk 2 . | Follow-up wk 4 . | Follow-up wk 6 . |
| CD4 T-cells | |||||||||||
| Mean ± SEM (%) | 11.59 ± 0.86 | 14.08 ± 1.68 | 14.24 ± 1.40 | 14.49 ± 1.63 | 12.70 ± 0.77 | 15.30 ± 1.38 | 11.70 ± 0.73 | 13.50 ± 1.80 | 12.30 ± 2.17 | 10.48 ± 0.99 | 10.48 ± 0.99 |
| P value (compared with predose) | .199 | .114 | .127 | .349 | .025 | .927 | .288 | .739 | .404 | .433 | |
| N = 132 | 15 | 15 | 14 | 15 | 14 | 11 | 12 | 8 | 11 | 9 | 8 |
| T-LGLL cells | |||||||||||
| Mean ± SEM (%) | 14.46 ± 2.06 | 48.36 ± 4.04 | 32.79 ± 5.67 | 35.92 ± 5.99 | 40.55 ± 5.38 | 37.25 ± 7.30 | 33.20 ± 5.98 | 30.50 ± 5.15 | 29.65 ± 4.11 | 15.02 ± 4.37 | 17.80 ± 3.75 |
| P value (compared with predose) | < .001 | .004 | .002 | < .001 | .002 | .003 | .002 | .002 | .697 | .403 | |
| N = 132 | 15 | 15 | 14 | 15 | 14 | 11 | 12 | 8 | 11 | 9 | 8 |
| . | 1-month treatment . | Extended treatment . | Washout . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Predose . | D 2 . | D 8 . | D 15 . | D 29 . | Wk 9 . | Wk 13 . | Wk 17 . | Follow-up wk 2 . | Follow-up wk 4 . | Follow-up wk 6 . |
| CD4 T-cells | |||||||||||
| Mean ± SEM (%) | 11.59 ± 0.86 | 14.08 ± 1.68 | 14.24 ± 1.40 | 14.49 ± 1.63 | 12.70 ± 0.77 | 15.30 ± 1.38 | 11.70 ± 0.73 | 13.50 ± 1.80 | 12.30 ± 2.17 | 10.48 ± 0.99 | 10.48 ± 0.99 |
| P value (compared with predose) | .199 | .114 | .127 | .349 | .025 | .927 | .288 | .739 | .404 | .433 | |
| N = 132 | 15 | 15 | 14 | 15 | 14 | 11 | 12 | 8 | 11 | 9 | 8 |
| T-LGLL cells | |||||||||||
| Mean ± SEM (%) | 14.46 ± 2.06 | 48.36 ± 4.04 | 32.79 ± 5.67 | 35.92 ± 5.99 | 40.55 ± 5.38 | 37.25 ± 7.30 | 33.20 ± 5.98 | 30.50 ± 5.15 | 29.65 ± 4.11 | 15.02 ± 4.37 | 17.80 ± 3.75 |
| P value (compared with predose) | < .001 | .004 | .002 | < .001 | .002 | .003 | .002 | .002 | .697 | .403 | |
| N = 132 | 15 | 15 | 14 | 15 | 14 | 11 | 12 | 8 | 11 | 9 | 8 |
Averages and standard deviations of the percentages of apoptotic cells within each subset (CD4 T cells or T-LGLL cells) were calculated. Average (of the % apoptotic cells within each subset) at given day of the treatment was compared with that of day 1 (pretreatment) and Student t test was performed to determine the P values to see whether the difference was significant (P < .05, shown in italic).
Numbers given in the table are the P values of each comparison.
Apoptotic percentages in the T-LGLL subset showed a significant difference from that at pretreatment at all times during treatment, whereas apoptotic death of CD4 T cells showed no significant deviation from that at pretreatment.
During the washout period, apoptotic death of T-LGLL subsided to the baseline level at pretreatment.
SEM, standard error of the mean.