Adjusted ORs for HHT in individuals with bleeding, using multivariable logistic regression
| Variable . | OR . | 95% CIs . | P value . |
|---|---|---|---|
| Liver disease | Omnibus P < .001 | ||
| No liver disease | Reference | ||
| Cirrhosis | 4.03 | 2.74-5.93 | < .001 |
| Moderate or severe liver disease | 2.71 | 1.47-4.98 | .001 |
| Mild liver disease | 0.91 | 0.41-2.04 | .819 |
| Congestive heart failure | 2.43 | 1.89-3.13 | < .001 |
| Iron deficiency anemia | 2.27 | 1.84-2.81 | < .001 |
| HCV | 1.78 | 1.11-2.86 | .017 |
| Metastatic cancer | 1.54 | 0.67-3.54 | .305 |
| GERD | 1.46 | 1.21-1.76 | < .001 |
| Age per 10 y (continuous) | 1.11 | 1.06-1.16 | < .001 |
| Diabetes with complications | 1.11 | 0.79-1.57 | .533 |
| Renal disease | 1.04 | 0.78-1.39 | .787 |
| Portal HTN | 0.99 | 0.61-1.61 | .975 |
| Charlson score | 0.85 | 0.79-0.92 | < .001 |
| Hyperlipidemia | 0.70 | 0.56-0.86 | .001 |
| Obesity | 0.62 | 0.47, 0.82 | .001 |
| End-stage renal disease | 0.59 | 0.35-1.00 | .051 |
| Malignancy | 0.51 | 0.33-0.79 | .002 |
| Dementia | 0.44 | 0.20- 0.99 | .046 |
| Anticoagulation | 0.44 | 0.30-0.62 | < .001 |
| Aspirin use | 0.32 | 0.22-0.47 | < .001 |
| INR > 1.5 | 0.32 | 0.10-1.00 | .051 |
| Bariatric surgery | 0.30 | 0.10-0.95 | .041 |
| NSAIDs use | 0.24 | 0.06-0.98 | .047 |
| Variable . | OR . | 95% CIs . | P value . |
|---|---|---|---|
| Liver disease | Omnibus P < .001 | ||
| No liver disease | Reference | ||
| Cirrhosis | 4.03 | 2.74-5.93 | < .001 |
| Moderate or severe liver disease | 2.71 | 1.47-4.98 | .001 |
| Mild liver disease | 0.91 | 0.41-2.04 | .819 |
| Congestive heart failure | 2.43 | 1.89-3.13 | < .001 |
| Iron deficiency anemia | 2.27 | 1.84-2.81 | < .001 |
| HCV | 1.78 | 1.11-2.86 | .017 |
| Metastatic cancer | 1.54 | 0.67-3.54 | .305 |
| GERD | 1.46 | 1.21-1.76 | < .001 |
| Age per 10 y (continuous) | 1.11 | 1.06-1.16 | < .001 |
| Diabetes with complications | 1.11 | 0.79-1.57 | .533 |
| Renal disease | 1.04 | 0.78-1.39 | .787 |
| Portal HTN | 0.99 | 0.61-1.61 | .975 |
| Charlson score | 0.85 | 0.79-0.92 | < .001 |
| Hyperlipidemia | 0.70 | 0.56-0.86 | .001 |
| Obesity | 0.62 | 0.47, 0.82 | .001 |
| End-stage renal disease | 0.59 | 0.35-1.00 | .051 |
| Malignancy | 0.51 | 0.33-0.79 | .002 |
| Dementia | 0.44 | 0.20- 0.99 | .046 |
| Anticoagulation | 0.44 | 0.30-0.62 | < .001 |
| Aspirin use | 0.32 | 0.22-0.47 | < .001 |
| INR > 1.5 | 0.32 | 0.10-1.00 | .051 |
| Bariatric surgery | 0.30 | 0.10-0.95 | .041 |
| NSAIDs use | 0.24 | 0.06-0.98 | .047 |
GERD, gastroesophageal reflux; INR, international normalized ratio; NSAID, nonsteroidal anti-inflammatory agent.