Comorbidities associated with bleeding in individuals with and without HHT
| Variable . | HHT with bleeding . | No HHT with bleeding . | P value . |
|---|---|---|---|
| Percent or mean (standard error) . | |||
| n (%) | 648 (0.06%) | 1 005 594 (99.94%) | |
| Congestive heart failure | 26.7 | 18.3 | < .001 |
| GERD | 25.9 | 20.0 | .001 |
| Hyperlipidemia | 21.9 | 30.0 | < .001 |
| Renal disease | 17.6 | 20.9 | .048 |
| Iron deficiency anemia | 15.7 | 7.5 | < .001 |
| Obesity | 10.0 | 15.5 | < .001 |
| Liver disease | |||
| Cirrhosis | 10.0 | 3.6 | < .001 |
| Portal HTN | 7.3 | 3.9 | < .001 |
| HCV | 3.4 | 1.3 | < .001 |
| Postnecrotic cirrhosis | 2.3 | 0.7 | < .001 |
| Diabetes with complications | 8.8 | 11.7 | .023 |
| Anticoagulation | 5.2 | 10.7 | < .001 |
| Aspirin use | 4.6 | 13.5 | < .001 |
| Malignancy | 4.0 | 10.1 | < .001 |
| Inpatient mortality | 1.9 | 3.6 | .017 |
| Platelet transfusion | 1.2 | 1.4 | .653 |
| Blood or blood product transfusion | 0.0 | 0.0 | NA |
| Length of stay (d) | 5.5 (0.2) | 6.0 (0.0) | .043 |
| Charlson comorbidity score | 2.3 (0.1) | 2.6 (0.0) | .005 |
| Variable . | HHT with bleeding . | No HHT with bleeding . | P value . |
|---|---|---|---|
| Percent or mean (standard error) . | |||
| n (%) | 648 (0.06%) | 1 005 594 (99.94%) | |
| Congestive heart failure | 26.7 | 18.3 | < .001 |
| GERD | 25.9 | 20.0 | .001 |
| Hyperlipidemia | 21.9 | 30.0 | < .001 |
| Renal disease | 17.6 | 20.9 | .048 |
| Iron deficiency anemia | 15.7 | 7.5 | < .001 |
| Obesity | 10.0 | 15.5 | < .001 |
| Liver disease | |||
| Cirrhosis | 10.0 | 3.6 | < .001 |
| Portal HTN | 7.3 | 3.9 | < .001 |
| HCV | 3.4 | 1.3 | < .001 |
| Postnecrotic cirrhosis | 2.3 | 0.7 | < .001 |
| Diabetes with complications | 8.8 | 11.7 | .023 |
| Anticoagulation | 5.2 | 10.7 | < .001 |
| Aspirin use | 4.6 | 13.5 | < .001 |
| Malignancy | 4.0 | 10.1 | < .001 |
| Inpatient mortality | 1.9 | 3.6 | .017 |
| Platelet transfusion | 1.2 | 1.4 | .653 |
| Blood or blood product transfusion | 0.0 | 0.0 | NA |
| Length of stay (d) | 5.5 (0.2) | 6.0 (0.0) | .043 |
| Charlson comorbidity score | 2.3 (0.1) | 2.6 (0.0) | .005 |
GERD, gastroesophageal reflux; NA, not available.