Types of bleeding in individuals with and without HHT
| . | HHT with bleeding . | No HHT with bleeding . | . |
|---|---|---|---|
| Variable . | Percent or mean (standard error) . | P value . | |
| n (%) | 648 (0.06%) | 1 005 594 (99.94%) | |
| Age (y) | 63.1 (0.6) | 62.0 (0.1) | .060 |
| Gender (female) | 55.2 | 57.5 | .273 |
| GI bleeding | 70.4 | 76.6 | < .001 |
| Upper GI bleeding | 36.1 | 36.9 | .684 |
| Angiodysplasia | 18.1 | 1.6 | < .001 |
| Gastric and/or duodenal ulcers | 6.5 | 12.3 | < .001 |
| Esophagitis | 4.3 | 10.6 | < .001 |
| Gastritis/duodenitis | 1.4 | 3.7 | .002 |
| Lower GI bleeding | 19.9 | 30.1 | < .001 |
| Diverticulosis | 9.9 | 17.0 | < .001 |
| Angiodysplasia | 5.4 | 0.7 | < .001 |
| Rectal (hemorrhoid, fissure, or ulcer) | 3.5 | 6.3 | .004 |
| Inflammatory bowel disease | 1.4 | 5.2 | < .001 |
| AVM | 31.9 | 1.3 | .001 |
| GI AVM | 20.1 | 1.0 | < .001 |
| Spinal AVM | 9.6 | 0.1 | < .001 |
| Pulmonry AVM | 7.7 | 0.0 | < .001 |
| Cerebral AVM | 5.1 | 0.5 | < .001 |
| Epistaxis | 17.9 | 0.6 | < .001 |
| HMB∗ | 4.1 | 24.9 | < .001 |
| Postpartum hemorrhage∗ | 4.1 | 41.5 | < .001 |
| Telangiectasia | 2.3 | 0.2 | < .001 |
| Surgical/procedural bleeding | 0.8 | 4.1 | < .001 |
| . | HHT with bleeding . | No HHT with bleeding . | . |
|---|---|---|---|
| Variable . | Percent or mean (standard error) . | P value . | |
| n (%) | 648 (0.06%) | 1 005 594 (99.94%) | |
| Age (y) | 63.1 (0.6) | 62.0 (0.1) | .060 |
| Gender (female) | 55.2 | 57.5 | .273 |
| GI bleeding | 70.4 | 76.6 | < .001 |
| Upper GI bleeding | 36.1 | 36.9 | .684 |
| Angiodysplasia | 18.1 | 1.6 | < .001 |
| Gastric and/or duodenal ulcers | 6.5 | 12.3 | < .001 |
| Esophagitis | 4.3 | 10.6 | < .001 |
| Gastritis/duodenitis | 1.4 | 3.7 | .002 |
| Lower GI bleeding | 19.9 | 30.1 | < .001 |
| Diverticulosis | 9.9 | 17.0 | < .001 |
| Angiodysplasia | 5.4 | 0.7 | < .001 |
| Rectal (hemorrhoid, fissure, or ulcer) | 3.5 | 6.3 | .004 |
| Inflammatory bowel disease | 1.4 | 5.2 | < .001 |
| AVM | 31.9 | 1.3 | .001 |
| GI AVM | 20.1 | 1.0 | < .001 |
| Spinal AVM | 9.6 | 0.1 | < .001 |
| Pulmonry AVM | 7.7 | 0.0 | < .001 |
| Cerebral AVM | 5.1 | 0.5 | < .001 |
| Epistaxis | 17.9 | 0.6 | < .001 |
| HMB∗ | 4.1 | 24.9 | < .001 |
| Postpartum hemorrhage∗ | 4.1 | 41.5 | < .001 |
| Telangiectasia | 2.3 | 0.2 | < .001 |
| Surgical/procedural bleeding | 0.8 | 4.1 | < .001 |
Analysis limited to females of reproductive potential (15-45 years of age).