Characteristics of therapy group participants who experienced a stroke recurrence (n = 11) or died (n = 5) during the trial
| Patient ID . | Age at enrollment, y . | Time from beginning hydroxyurea to end point, mo . | End point classification . | Description of stroke or death . | Mean dose of hydroxyurea, mg/kg per d . | Steady-state Hb, g/dL . | Hb at end point g/dL . |
|---|---|---|---|---|---|---|---|
| 1 | 5.6 | 9.5 | Stroke | Presented with acute worsening of mild left-sided weakness PedNIHSS 11. Adjudicated as a new stroke | 10.3 | 11.40 | 8.00 |
| 2 | 2.1 | 2.4 | Death | Fever with anemia | 10.0 | 7.1 | 7.1 |
| 3 | 5.5 | 3.4 | Stroke | Seizure and new left hemiparesis PedNIHSS increased from 3 to 28 | 12.1 | 7.90 | 8.00 |
| 4 | 6.0 | 19.0 | Stroke | Sudden onset of right hemiparesis and aphasia PedNIHSS increased from 3 to 14 | 11.6 | 7.00 | 7.70 |
| 5 | 4.0 | 17.8 | Stroke | Sudden worsening of baseline left hemiparesis, now requires a hand held to walk PedNIHSS increased from 4 to 6 | 13.6 | 8.30 | 9.00 |
| 6 | 5.4 | 8.8 | Stroke | Seizure followed by persistent worsening of left hemiparesis PedNIHSS increased from 5 to 8 | 11.3 | 7.48 | 7.00 |
| 7 | 6.6 | 4.5 | Stroke | Seizure followed by persistent worsening of left hemiparesis No longer has any use of left hand PedNIHSS increased from 3 to 8 | 13.2 | 10.30 | 7.00 |
| 8 | 7.4 | 10.7 | Death | Seizure Cause of death unclear | 10.1 | 6.1 | 6.9 |
| 9 | 3.8 | 7.4 | Stroke | Acute onset right hemiparesis, face, and arm with dysarthria PedNIHSS was 3 at baseline and 3 days after new event was 6 | 24.2 | 8.10 | 8.80 |
| 10 | 11.2 | 3.0 | Stroke | Presented with focal seizure and worsened right hemiparesis, PedNIHSS increased from 3 to 5 | 20.3 | 11.00 | 10.80 |
| 11 | 6.1 | 4.8 | Stroke | During a pain episode, sudden onset of new left-sided hemiparesis in a child with prior right hemiparesis PedNIHSS increased from 10 to 15 | 20.4 | 7.60 | 9.00 |
| 12 | 7.3 | 23.6 | Stroke | Fever with seizure and new left hemiparesis PedNIHSS increased from 7 to 24 | 19.8 | 8.60 | 7.90 |
| 13 | 3.0 | 8.7 | Death | Fever | 23.7 | 7.9 | 6.5 |
| 14 | 1.9 | 10.4 | Death | Acute chest syndrome | 25.0 | 6.1 | 6.0 |
| 15 | 5.8 | 11.9 | Stroke | Sudden, profound aphasia and weakness of all 4 extremities PedNIHSS was 6 at study entry due to right-sided weakness PedNIHSS worsened to 19 for right- and left-sided weakness, consistent with bilateral infarcts | 23.4 | 8.30 | 9.00 |
| 16 | 8.9 | 0.4 | Death | Acute chest syndrome | 17.7 | 7.8 | NA |
| Patient ID . | Age at enrollment, y . | Time from beginning hydroxyurea to end point, mo . | End point classification . | Description of stroke or death . | Mean dose of hydroxyurea, mg/kg per d . | Steady-state Hb, g/dL . | Hb at end point g/dL . |
|---|---|---|---|---|---|---|---|
| 1 | 5.6 | 9.5 | Stroke | Presented with acute worsening of mild left-sided weakness PedNIHSS 11. Adjudicated as a new stroke | 10.3 | 11.40 | 8.00 |
| 2 | 2.1 | 2.4 | Death | Fever with anemia | 10.0 | 7.1 | 7.1 |
| 3 | 5.5 | 3.4 | Stroke | Seizure and new left hemiparesis PedNIHSS increased from 3 to 28 | 12.1 | 7.90 | 8.00 |
| 4 | 6.0 | 19.0 | Stroke | Sudden onset of right hemiparesis and aphasia PedNIHSS increased from 3 to 14 | 11.6 | 7.00 | 7.70 |
| 5 | 4.0 | 17.8 | Stroke | Sudden worsening of baseline left hemiparesis, now requires a hand held to walk PedNIHSS increased from 4 to 6 | 13.6 | 8.30 | 9.00 |
| 6 | 5.4 | 8.8 | Stroke | Seizure followed by persistent worsening of left hemiparesis PedNIHSS increased from 5 to 8 | 11.3 | 7.48 | 7.00 |
| 7 | 6.6 | 4.5 | Stroke | Seizure followed by persistent worsening of left hemiparesis No longer has any use of left hand PedNIHSS increased from 3 to 8 | 13.2 | 10.30 | 7.00 |
| 8 | 7.4 | 10.7 | Death | Seizure Cause of death unclear | 10.1 | 6.1 | 6.9 |
| 9 | 3.8 | 7.4 | Stroke | Acute onset right hemiparesis, face, and arm with dysarthria PedNIHSS was 3 at baseline and 3 days after new event was 6 | 24.2 | 8.10 | 8.80 |
| 10 | 11.2 | 3.0 | Stroke | Presented with focal seizure and worsened right hemiparesis, PedNIHSS increased from 3 to 5 | 20.3 | 11.00 | 10.80 |
| 11 | 6.1 | 4.8 | Stroke | During a pain episode, sudden onset of new left-sided hemiparesis in a child with prior right hemiparesis PedNIHSS increased from 10 to 15 | 20.4 | 7.60 | 9.00 |
| 12 | 7.3 | 23.6 | Stroke | Fever with seizure and new left hemiparesis PedNIHSS increased from 7 to 24 | 19.8 | 8.60 | 7.90 |
| 13 | 3.0 | 8.7 | Death | Fever | 23.7 | 7.9 | 6.5 |
| 14 | 1.9 | 10.4 | Death | Acute chest syndrome | 25.0 | 6.1 | 6.0 |
| 15 | 5.8 | 11.9 | Stroke | Sudden, profound aphasia and weakness of all 4 extremities PedNIHSS was 6 at study entry due to right-sided weakness PedNIHSS worsened to 19 for right- and left-sided weakness, consistent with bilateral infarcts | 23.4 | 8.30 | 9.00 |
| 16 | 8.9 | 0.4 | Death | Acute chest syndrome | 17.7 | 7.8 | NA |