HRQoL scores and thresholds for MIDs
| Questionnaire . | Subscales . | T0 . | T1 . | T2 . | T3 . | Ptrend . | ||
|---|---|---|---|---|---|---|---|---|
| Mean . | SD . | MID∗ . | ||||||
| EORTC QLQ-30 | Global health status | 72.2 | 23.4 | 5.9 | 83.3 | 83.1 | 82.8 | <.001† |
| Physical functioning | 79.7 | 19.6 | 8.6 | 88.9 | 89.6 | 88.4 | <.001† | |
| Role functioning | 71.0 | 35.1 | 10.9 | 89.2 | 90.5 | 88.2 | <.001† | |
| Emotional functioning | 78.2 | 20.0 | 7.84 | 88.5 | 87.0 | 86.9 | <.001† | |
| Cognitive functioning | 87.7 | 19.6 | 11.1 | 87.3 | 89.4 | 87.5 | .780 | |
| Social functioning | 84.4 | 22.4 | 12.7 | 89.4 | 93.1 | 91.3 | .004 | |
| Fatigue | 34.6 | 28.7 | 10.3 | 19.1 | 16.9 | 13.1 | <.001† | |
| Nausea and vomiting | 2.86 | 7.60 | 5.26 | 4.76 | 2.30 | 1.14 | .265 | |
| Pain | 16.9 | 25.8 | 12.8 | 9.79 | 6.32 | 7.95 | <.001 | |
| Dyspnea | 30.7 | 35.3 | 17.6 | 12.7 | 12.1 | 13.6 | <.001† | |
| Insomnia | 24.5 | 28.0 | 14.0 | 14.8 | 19.0 | 18.2 | .075 | |
| Appetite loss | 16.2 | 29.1 | 14.6 | 7.41 | 5.75 | 3.03 | <.001 | |
| Constipation | 8.85 | 21.6 | 10.8 | 6.88 | 8.05 | 10.9 | .727 | |
| Diarrhea | 11.5 | 20.8 | 10.4 | 14.2 | 7.47 | 4.65 | .036 | |
| Financial difficulties | 3.13 | 12.9 | 6.45 | 0.53 | 0.57 | 0.78 | .094 | |
| EORTC QLQ-CLL17 | Symptom burden | 18.0 | 16.8 | 9.87 | 9.10 | 8.60 | 12.2 | <.001 |
| Physical condition/fatigue | 30.0 | 26.4 | 10.8 | 13.8 | 14.5 | 11.6 | <.001† | |
| Worriers/fears | 29.4 | 18.4 | 8.70 | 17.3 | 15.4 | 19.4 | <.001† | |
| Questionnaire . | Subscales . | T0 . | T1 . | T2 . | T3 . | Ptrend . | ||
|---|---|---|---|---|---|---|---|---|
| Mean . | SD . | MID∗ . | ||||||
| EORTC QLQ-30 | Global health status | 72.2 | 23.4 | 5.9 | 83.3 | 83.1 | 82.8 | <.001† |
| Physical functioning | 79.7 | 19.6 | 8.6 | 88.9 | 89.6 | 88.4 | <.001† | |
| Role functioning | 71.0 | 35.1 | 10.9 | 89.2 | 90.5 | 88.2 | <.001† | |
| Emotional functioning | 78.2 | 20.0 | 7.84 | 88.5 | 87.0 | 86.9 | <.001† | |
| Cognitive functioning | 87.7 | 19.6 | 11.1 | 87.3 | 89.4 | 87.5 | .780 | |
| Social functioning | 84.4 | 22.4 | 12.7 | 89.4 | 93.1 | 91.3 | .004 | |
| Fatigue | 34.6 | 28.7 | 10.3 | 19.1 | 16.9 | 13.1 | <.001† | |
| Nausea and vomiting | 2.86 | 7.60 | 5.26 | 4.76 | 2.30 | 1.14 | .265 | |
| Pain | 16.9 | 25.8 | 12.8 | 9.79 | 6.32 | 7.95 | <.001 | |
| Dyspnea | 30.7 | 35.3 | 17.6 | 12.7 | 12.1 | 13.6 | <.001† | |
| Insomnia | 24.5 | 28.0 | 14.0 | 14.8 | 19.0 | 18.2 | .075 | |
| Appetite loss | 16.2 | 29.1 | 14.6 | 7.41 | 5.75 | 3.03 | <.001 | |
| Constipation | 8.85 | 21.6 | 10.8 | 6.88 | 8.05 | 10.9 | .727 | |
| Diarrhea | 11.5 | 20.8 | 10.4 | 14.2 | 7.47 | 4.65 | .036 | |
| Financial difficulties | 3.13 | 12.9 | 6.45 | 0.53 | 0.57 | 0.78 | .094 | |
| EORTC QLQ-CLL17 | Symptom burden | 18.0 | 16.8 | 9.87 | 9.10 | 8.60 | 12.2 | <.001 |
| Physical condition/fatigue | 30.0 | 26.4 | 10.8 | 13.8 | 14.5 | 11.6 | <.001† | |
| Worriers/fears | 29.4 | 18.4 | 8.70 | 17.3 | 15.4 | 19.4 | <.001† | |
SD, standard deviation; T, timepoint.
MID values are based on either the SD of the baseline score (ie, T0) for single-item scales, or on the SD of the baseline score times the square root of (1-Cronbach alpha) for multiscale items depicted in bold.
P values represent a significant change over time as well as a change from baseline that is above the MID value at least at 1 timepoint.