Associations between PRS of SCZ, BD, and MDD and the risk of VTE in UKB
| PRS . | Model . | Sex-combined . | Men . | Women . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R2∗ . | OR . | CI . | P value . | N . | R2∗ . | OR . | CI . | P value . | N . | R2∗ . | OR . | CI . | P value . | N . | ||
| SCZ | 1 | 0.013 | 1.00 | 0.97-1.02 | .688 | 241 483 | 0.011 | 0.96 | 0.93-1.00 | .028 | 114 854 | 0.012 | 1.02 | 0.99-1.05 | .182 | 126 629 |
| 2 | 0.017 | 1.00 | 0.98-1.02 | .818 | 241 470 | 0.017 | 0.97 | 0.93-1.00 | .049 | 114 850 | 0.015 | 1.02 | 0.99-1.05 | .164 | 126 620 | |
| 3 | 0.034 | 1.00 | 0.98-1.03 | .787 | 232 482 | 0.033 | 0.97 | 0.93-1.00 | .072 | 111 361 | 0.033 | 1.03 | 0.99-1.06 | .057 | 121 121 | |
| 4 | 0.033 | 1.03 | 1.00-1.06 | .058 | 120 685 | |||||||||||
| BD | 1 | 0.013 | 1.03 | 1.01-1.06 | .002 | 241 483 | 0.010 | 1.03 | 1.00-1.07 | .069 | 114 854 | 0.012 | 1.04 | 1.01-1.07 | .013 | 126 629 |
| 2 | 0.017 | 1.04 | 1.01-1.06 | .002 | 241 470 | 0.017 | 1.03 | 1.00-1.07 | .058 | 114 850 | 0.015 | 1.04 | 1.01-1.07 | .012 | 126 620 | |
| 3 | 0.034 | 1.04 | 1.01-1.06 | .002 | 232 482 | 0.030 | 1.03 | 1.00-1.07 | .073 | 111 361 | 0.033 | 1.04 | 1.01-1.07 | .011 | 121 121 | |
| 4 | 0.033 | 1.04 | 1.01-1.07 | .012 | 120 685 | |||||||||||
| MDD | 1 | 0.014 | 1.08 | 1.06-1.10 | <.001 | 284 866 | 0.012 | 1.07 | 1.03-1.10 | <.001 | 135 152 | 0.014 | 1.09 | 1.06-1.12 | <.001 | 149 714 |
| 2 | 0.019 | 1.08 | 1.06-1.10 | <.001 | 284 788 | 0.018 | 1.07 | 1.03-1.10 | <.001 | 135 123 | 0.017 | 1.09 | 1.06-1.12 | <.001 | 149 665 | |
| 3 | 0.036 | 1.07 | 1.04-1.09 | <.001 | 274 064 | 0.034 | 1.05 | 1.02-1.09 | .004 | 130 864 | 0.035 | 1.07 | 1.04-1.11 | <.001 | 143 200 | |
| 4 | 0.035 | 1.07 | 1.04-1.11 | <.001 | 142 542 | |||||||||||
| PRS . | Model . | Sex-combined . | Men . | Women . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R2∗ . | OR . | CI . | P value . | N . | R2∗ . | OR . | CI . | P value . | N . | R2∗ . | OR . | CI . | P value . | N . | ||
| SCZ | 1 | 0.013 | 1.00 | 0.97-1.02 | .688 | 241 483 | 0.011 | 0.96 | 0.93-1.00 | .028 | 114 854 | 0.012 | 1.02 | 0.99-1.05 | .182 | 126 629 |
| 2 | 0.017 | 1.00 | 0.98-1.02 | .818 | 241 470 | 0.017 | 0.97 | 0.93-1.00 | .049 | 114 850 | 0.015 | 1.02 | 0.99-1.05 | .164 | 126 620 | |
| 3 | 0.034 | 1.00 | 0.98-1.03 | .787 | 232 482 | 0.033 | 0.97 | 0.93-1.00 | .072 | 111 361 | 0.033 | 1.03 | 0.99-1.06 | .057 | 121 121 | |
| 4 | 0.033 | 1.03 | 1.00-1.06 | .058 | 120 685 | |||||||||||
| BD | 1 | 0.013 | 1.03 | 1.01-1.06 | .002 | 241 483 | 0.010 | 1.03 | 1.00-1.07 | .069 | 114 854 | 0.012 | 1.04 | 1.01-1.07 | .013 | 126 629 |
| 2 | 0.017 | 1.04 | 1.01-1.06 | .002 | 241 470 | 0.017 | 1.03 | 1.00-1.07 | .058 | 114 850 | 0.015 | 1.04 | 1.01-1.07 | .012 | 126 620 | |
| 3 | 0.034 | 1.04 | 1.01-1.06 | .002 | 232 482 | 0.030 | 1.03 | 1.00-1.07 | .073 | 111 361 | 0.033 | 1.04 | 1.01-1.07 | .011 | 121 121 | |
| 4 | 0.033 | 1.04 | 1.01-1.07 | .012 | 120 685 | |||||||||||
| MDD | 1 | 0.014 | 1.08 | 1.06-1.10 | <.001 | 284 866 | 0.012 | 1.07 | 1.03-1.10 | <.001 | 135 152 | 0.014 | 1.09 | 1.06-1.12 | <.001 | 149 714 |
| 2 | 0.019 | 1.08 | 1.06-1.10 | <.001 | 284 788 | 0.018 | 1.07 | 1.03-1.10 | <.001 | 135 123 | 0.017 | 1.09 | 1.06-1.12 | <.001 | 149 665 | |
| 3 | 0.036 | 1.07 | 1.04-1.09 | <.001 | 274 064 | 0.034 | 1.05 | 1.02-1.09 | .004 | 130 864 | 0.035 | 1.07 | 1.04-1.11 | <.001 | 143 200 | |
| 4 | 0.035 | 1.07 | 1.04-1.11 | <.001 | 142 542 | |||||||||||
Model 1: age, principal genetic components 1 to 8 (PGC1-8) and genotyping chip; model 2: model 1 plus blood group; model 3: model 2 plus BMI, ever smoking and any antipsychotic medication; model 4 (women only), model 3 plus exogenous hormones (hormone replacement therapy and oral contraceptives).
R2∗, pseudo R2.
Boldface indicates singificant P values.