CfDNA allelic load levels and the incidence of relapses
| Patient (MIS ID) . | cfDNA allelic load level at vemu cessation, % . | cfDNA allelic load level at therapy end, % . | Relapse . |
|---|---|---|---|
| 147958 (RO+) | <LoD | Relapse | Yes (RO–) |
| 153888 (RO+) | <LoD | 0.86 | Yes (RO–) |
| 127734 (RO–) | <LoD | Relapse | Yes (RO–) |
| 181102 (RO+) | 1.18 | 2.33 | Yes (RO+) |
| 159833 (RO+) | 0.33 | 0.24 | No |
| 187463 (RO+) | <LoD | <LoD | No |
| 190889 (RO+) | 0.51 | 1.55 | No |
| 186934 (RO+) | 0.2 | 0.54 | No |
| 202807 (RO+) | 0.94 | 0.16 | No |
| 132056 (RO+) | <LoD | 0.5 | No |
| 189102 (RO+) | <LoD | <LoD | No |
| 116953 (RO+) | 0.34 | <LoD | No |
| 188277 (RO+) | 0.12 | <LoD | No |
| 209525 (RO+) | 0.39 | <LoD | No |
| 23245 (RO–) | n/d | n/d | No |
| 71021 (RO–) | 0.56 | <LoD | No |
| 50799 (RO–) | <LoD | <LoD | No |
| 143428 (RO–) | 0.07 | 0.42 | No |
| 76298 (RO–) | <LoD | <LoD | No |
| Patient (MIS ID) . | cfDNA allelic load level at vemu cessation, % . | cfDNA allelic load level at therapy end, % . | Relapse . |
|---|---|---|---|
| 147958 (RO+) | <LoD | Relapse | Yes (RO–) |
| 153888 (RO+) | <LoD | 0.86 | Yes (RO–) |
| 127734 (RO–) | <LoD | Relapse | Yes (RO–) |
| 181102 (RO+) | 1.18 | 2.33 | Yes (RO+) |
| 159833 (RO+) | 0.33 | 0.24 | No |
| 187463 (RO+) | <LoD | <LoD | No |
| 190889 (RO+) | 0.51 | 1.55 | No |
| 186934 (RO+) | 0.2 | 0.54 | No |
| 202807 (RO+) | 0.94 | 0.16 | No |
| 132056 (RO+) | <LoD | 0.5 | No |
| 189102 (RO+) | <LoD | <LoD | No |
| 116953 (RO+) | 0.34 | <LoD | No |
| 188277 (RO+) | 0.12 | <LoD | No |
| 209525 (RO+) | 0.39 | <LoD | No |
| 23245 (RO–) | n/d | n/d | No |
| 71021 (RO–) | 0.56 | <LoD | No |
| 50799 (RO–) | <LoD | <LoD | No |
| 143428 (RO–) | 0.07 | 0.42 | No |
| 76298 (RO–) | <LoD | <LoD | No |
LoD, limit of detection; n/d, no data.
Relapsed patients and allelic load at therapy end: 2/4 n/d, 2/4 >LoD (2.33% RO+, 0.86% RO–).
Patients in remission and allelic load at therapy end: 8/14 <LoD, 6/14 >LoD (median at therapy end, 0.46%; range, 0.16%-1.55%).