Multivariable linear regression
| Protocol . | Primary cumulative analysis . | Secondary focused analysis . | Interpretation . |
|---|---|---|---|
| CD19 | 0.20 × age + 0.034 × actual (0-99) marrow disease level Adjusted r2 = 0.46 | 0.94×(1, 2, or 3 depending on marrow disease) + 2.33 (if EM disease) Adjusted r2 = 0.53 | Cumulative analysis: increasing age and marrow disease are predictive of higher NC AEs Focused analysis: presence of EM disease, rather than age, and categorical marrow disease were more accurate predictors |
| CD22 | 4.07×(1, 2, or 3 depending on marrow disease) − 3.87 (if prior CAR) Adjusted r2 = 0.51 | 2.465×(1, 2, or 3 depending on marrow disease) − 2.094 (if prior CAR) Adjusted r2 = 0.58 | Cumulative analysis: higher marrow disease as a categorical factor influences NC AEs, whereas receipt of prior CAR decreases the number of predicted NC AEs Focused analysis: Same factors influence NC AEs but to a lesser degree |
| CD1922 | 4.81 – 1.89×agecat + 1.16×(1, 2, or 3 depending on marrow disease) Agecat = 1 if <12 y Agecat = 2 if 12-17 y Agecat = 3 if ≥18 y Adjusted r2 = 0.60 | 2.1207 – 2.5172 (if age ≥18) + 0.7241× (1, 2, or 3 depending on marrow disease) Adjusted r2 = 0.65 | Cumulative analysis: NC AEs are predicted based on the categorical marrow disease; increased age decreases the number of predicted NC AEs Focused analysis: Same factors influence NC AEs but to a lesser degree in secondary analysis |
| Protocol . | Primary cumulative analysis . | Secondary focused analysis . | Interpretation . |
|---|---|---|---|
| CD19 | 0.20 × age + 0.034 × actual (0-99) marrow disease level Adjusted r2 = 0.46 | 0.94×(1, 2, or 3 depending on marrow disease) + 2.33 (if EM disease) Adjusted r2 = 0.53 | Cumulative analysis: increasing age and marrow disease are predictive of higher NC AEs Focused analysis: presence of EM disease, rather than age, and categorical marrow disease were more accurate predictors |
| CD22 | 4.07×(1, 2, or 3 depending on marrow disease) − 3.87 (if prior CAR) Adjusted r2 = 0.51 | 2.465×(1, 2, or 3 depending on marrow disease) − 2.094 (if prior CAR) Adjusted r2 = 0.58 | Cumulative analysis: higher marrow disease as a categorical factor influences NC AEs, whereas receipt of prior CAR decreases the number of predicted NC AEs Focused analysis: Same factors influence NC AEs but to a lesser degree |
| CD1922 | 4.81 – 1.89×agecat + 1.16×(1, 2, or 3 depending on marrow disease) Agecat = 1 if <12 y Agecat = 2 if 12-17 y Agecat = 3 if ≥18 y Adjusted r2 = 0.60 | 2.1207 – 2.5172 (if age ≥18) + 0.7241× (1, 2, or 3 depending on marrow disease) Adjusted r2 = 0.65 | Cumulative analysis: NC AEs are predicted based on the categorical marrow disease; increased age decreases the number of predicted NC AEs Focused analysis: Same factors influence NC AEs but to a lesser degree in secondary analysis |