Hepatocyte Tfrc knockout mice exhibit iron-restricted erythropoiesis
| Sex . | Genotype . | HCT (%) . | Hgb (g/dL) . | MCV (fL) . | MCH (pg) . | RDW (%) . |
|---|---|---|---|---|---|---|
| Male | Tfrcfl/fl;Alb-Cre− | 40.78 ± 0.81 | 13.56 ± 0.27 | 46.92 ± 0.37 | 15.61 ± 0.10 | 16.58 ± 0.12 |
| Tfrcfl/fl;Alb-Cre+ | 37.46 ± 0.61∗∗ | 12.58 ± 0.23∗ | 44.06 ± 0.29∗∗∗ | 14.80 ± 0.11∗∗∗ | 17.76 ± 0.31∗∗ | |
| Female | Tfrcfl/fl;Alb-Cre− | 40.71 ± 0.53 | 13.66 ± 0.24 | 46.84 ± 0.25 | 15.71 ± 0.08 | 16.45 ± 0.10 |
| Tfrcfl/fl;Alb-Cre+ | 38.69 ± 0.56∗ | 13.07 ± 0.24† | 44.53 ± 0.21∗∗∗ | 15.04 ± 0.10∗∗∗ | 17.44 ± 0.14∗∗∗ |
| Sex . | Genotype . | HCT (%) . | Hgb (g/dL) . | MCV (fL) . | MCH (pg) . | RDW (%) . |
|---|---|---|---|---|---|---|
| Male | Tfrcfl/fl;Alb-Cre− | 40.78 ± 0.81 | 13.56 ± 0.27 | 46.92 ± 0.37 | 15.61 ± 0.10 | 16.58 ± 0.12 |
| Tfrcfl/fl;Alb-Cre+ | 37.46 ± 0.61∗∗ | 12.58 ± 0.23∗ | 44.06 ± 0.29∗∗∗ | 14.80 ± 0.11∗∗∗ | 17.76 ± 0.31∗∗ | |
| Female | Tfrcfl/fl;Alb-Cre− | 40.71 ± 0.53 | 13.66 ± 0.24 | 46.84 ± 0.25 | 15.71 ± 0.08 | 16.45 ± 0.10 |
| Tfrcfl/fl;Alb-Cre+ | 38.69 ± 0.56∗ | 13.07 ± 0.24† | 44.53 ± 0.21∗∗∗ | 15.04 ± 0.10∗∗∗ | 17.44 ± 0.14∗∗∗ |
Data represent means ± SEM; n = 11 to 14 mice per group (8 weeks old).
HCT, hematocrit; Hgb, hemoglobin; MCV, mean cell volume; MCH, mean cell hemoglobin; RDW, red cell distribution width; SEM, standard error of the mean.
P < .05 vs sex-matched Tfrcfl/fl;Alb-Cre− mice by Student's t test.
P < .01 vs sex-matched Tfrcfl/fl;Alb-Cre− mice by Student's t test.
P < .001 vs sex-matched Tfrcfl/fl;Alb-Cre− mice by Student's t test.
P = .09 vs female Tfrcfl/fl;Alb-Cre− mice by Student t test.