Preparative regimen for first HSCT
| Drug . | Dose . | Days given . | Comments . |
|---|---|---|---|
| Hydroxyurea | 30 mg/kg | −48 to −21 | Participants B, D, G, H, I, J |
| Alemtuzumab | 3, 10, 15, 20 mg | −22 to −19 | Fixed dosing for all recipients |
| Fludarabine | 30 mg/m2 | −8 to −4 | |
| Melphalan | 140 mg/m2 | −3 | |
| Thiotepa | 4 mg/kg × 2 doses | −3 | Participants A, G, H |
| Tacrolimus | −3 through +100, then weaned as tolerated | ||
| Abatacept | 10 mg/kg | −1, +5, +14, +28, +60, +100, +180, +270, +360 | Participants D, H, I, J |
| Methotrexate | 7.5 mg/m2 | +2, +3, +6 |
| Drug . | Dose . | Days given . | Comments . |
|---|---|---|---|
| Hydroxyurea | 30 mg/kg | −48 to −21 | Participants B, D, G, H, I, J |
| Alemtuzumab | 3, 10, 15, 20 mg | −22 to −19 | Fixed dosing for all recipients |
| Fludarabine | 30 mg/m2 | −8 to −4 | |
| Melphalan | 140 mg/m2 | −3 | |
| Thiotepa | 4 mg/kg × 2 doses | −3 | Participants A, G, H |
| Tacrolimus | −3 through +100, then weaned as tolerated | ||
| Abatacept | 10 mg/kg | −1, +5, +14, +28, +60, +100, +180, +270, +360 | Participants D, H, I, J |
| Methotrexate | 7.5 mg/m2 | +2, +3, +6 |