Table 1.

Comparison between HSCT, CRTT, and control cohorts at baseline

HSCT (n = 10)CRTT (n = 20)Control (n = 20)
Median age, y (IQR) 11.6 (9.5-16.7) 13.1 (10.1-18.1) 11.3 (7.8-14.2) 
Sex, n (% female) 4 (40) 13 (65) 7 (35) 
Median Hb, g/dL (IQR) 9.1 (7.5-10.1) 9.1 (8.8-9.8) NA 
Median Hb S, % (IQR) 45.75 (35.9-74.2) 37.4 (29.7-47.5) NA 
Presence of infarction, n (%) 8 (80) 18 (90) NA 
Cerebral vasculopathy, n (%) 1 (10) 4 (20) NA 
Abnormal TCD, n (%) 3 (30) 6 (30) NA 
Median whole-brain CBF, mL/100 g per min (IQR)  93.5 (75.9-109.9) 86.8 (73.3-103.4) 69.8 (56.0-80.0) 
Median whole-brain OEF, % (IQR)  36.8 (34.3-42.2) 35.3 (32.7-38.6) 30.9 (27.5-31.9) 
HSCT (n = 10)CRTT (n = 20)Control (n = 20)
Median age, y (IQR) 11.6 (9.5-16.7) 13.1 (10.1-18.1) 11.3 (7.8-14.2) 
Sex, n (% female) 4 (40) 13 (65) 7 (35) 
Median Hb, g/dL (IQR) 9.1 (7.5-10.1) 9.1 (8.8-9.8) NA 
Median Hb S, % (IQR) 45.75 (35.9-74.2) 37.4 (29.7-47.5) NA 
Presence of infarction, n (%) 8 (80) 18 (90) NA 
Cerebral vasculopathy, n (%) 1 (10) 4 (20) NA 
Abnormal TCD, n (%) 3 (30) 6 (30) NA 
Median whole-brain CBF, mL/100 g per min (IQR)  93.5 (75.9-109.9) 86.8 (73.3-103.4) 69.8 (56.0-80.0) 
Median whole-brain OEF, % (IQR)  36.8 (34.3-42.2) 35.3 (32.7-38.6) 30.9 (27.5-31.9) 

All other comparisons are not significant.

IQR, interquartile range; NA, not applicable.

Kruskal-Wallis test P = .001; HSCT vs CRTT not significant (P = .811), HSCT vs control (P = .023), CRTT vs control (P = .003) (Dwass-Steel-Critchlow-Flinger post hoc pairwise P values adjusted for multiple comparisons).

Kruskal-Wallis test P < .001; HSCT vs CRTT not significant (P = .600), HSCT vs control (P = .010), CRTT vs control (P =.001) (Dwass-Steel-Critchlow-Flinger post hoc pairwise P values adjusted for multiple comparisons).

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