Table 5.

Generalized estimating equation models examining secondary outcomes across never-HCT, pre-HCT, and post-HCT groups after adjusting for covariates plus/minus change over time

MeasureParameterComparisonEstimate (95% CI)P
QOL (FACT-G) (greater than mean - 0.5 standard) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.25 (0.86-1.82) .2512 
 Group Post- vs never-HCT 1.37 (0.77-2.45) .2859 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 1.02 (0.94-1.10) .6542 
 Group change over time∗  Post- vs never-HCT 0.97 (0.92-1.03) .3057 
QOL (EuroQOL 5-dimensions index) (>33rd percentile) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.26 (0.89-1.79) .1859 
 Group Post- vs never-HCT 1.41 (0.82-2.43) .2098 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 1.00 (0.92-1.10) .9112 
 Group change over time∗  Post- vs never-HCT 1.00 (0.95-1.04) .8568 
Depressive symptoms (PHQ-9) (<10) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.04 (0.72-1.49) .8368 
 Group Post- vs never-HCT 2.01 (1.06-3.81) .0323 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 1.19 (1.05-1.35) .0055 
 Group change over time∗  Post- vs never-HCT 0.95 (0.89-1.01) .0913 
Social activities (social activity log) (≥1.13) Group Never-HCT Reference  
 Group Pre- vs never-HCT 2.06 (1.40-3.04) <.001 
 Group Post- vs never-HCT 1.27 (0.70-2.32) .4344 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.93 (0.87-0.99) .0346 
 Group change over time∗  Post- vs never-HCT 1.00 (0.95-1.05) .9789 
Perceived social support (ENRICHD social support inventory) (greater than mean - 0.5 standard) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.76 (1.21-2.57) .0033 
 Group Post- vs never-HCT 1.31 (0.76-2.25) .3341 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.95 (0.89-1.02) .1838 
 Group change over time∗  Post- vs never-HCT 1.00 (0.96-1.04) .97 
Instrumental activities of daily living (=14) Group Never-HCT Reference  
 Group Pre- vs never-HCT 0.98 (0.71-1.36) .9177 
 Group Post- vs never-HCT 0.39 (0.24-0.63) <.001 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.99 (0.93-1.06) .8508 
 Group change over time∗  Post- vs never-HCT 1.02 (0.98-1.07) .3102 
ADL (=14) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.67 (1.17-2.37) .0043 
 Group Post- vs never-HCT 0.98 (0.58-1.67) .9542 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.98 (0.91-1.05) .4973 
 Group change over time∗  Post- vs never-HCT 1.01 (0.96-1.06) .7107 
Frailty (4-MWT) (≥0.8 m/s) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.33 (0.94-1.89) .1119 
 Group Post- vs never-HCT 2.14 (1.14-3.99) .0171 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 1.11 (0.97-1.27) .1222 
 Group change over time∗  Post- vs never-HCT 0.95 (0.89-1.01) .1092 
Frailty (Fried frailty index) (=0) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.22 (0.77-1.93) .4019 
 Group Post- vs never-HCT 3.69 (1.48-9.23) .0051 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.93 (0.81-1.06) .2599 
 Group change over time∗  Post- vs never-HCT 0.91 (0.81-1.02) .1022 
Performance status (KPS) (>70) Group Never-HCT Reference  
 Group Pre- vs never-HCT 3.00 (2.01-4.46) <.001 
 Group Post- vs never-HCT 0.66 (0.41-1.05) .0804 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.94 (0.88-1.00) .0464 
 Group change over time∗  Post- vs never-HCT 1.00 (0.96-1.04) .9939 
MeasureParameterComparisonEstimate (95% CI)P
QOL (FACT-G) (greater than mean - 0.5 standard) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.25 (0.86-1.82) .2512 
 Group Post- vs never-HCT 1.37 (0.77-2.45) .2859 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 1.02 (0.94-1.10) .6542 
 Group change over time∗  Post- vs never-HCT 0.97 (0.92-1.03) .3057 
QOL (EuroQOL 5-dimensions index) (>33rd percentile) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.26 (0.89-1.79) .1859 
 Group Post- vs never-HCT 1.41 (0.82-2.43) .2098 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 1.00 (0.92-1.10) .9112 
 Group change over time∗  Post- vs never-HCT 1.00 (0.95-1.04) .8568 
Depressive symptoms (PHQ-9) (<10) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.04 (0.72-1.49) .8368 
 Group Post- vs never-HCT 2.01 (1.06-3.81) .0323 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 1.19 (1.05-1.35) .0055 
 Group change over time∗  Post- vs never-HCT 0.95 (0.89-1.01) .0913 
Social activities (social activity log) (≥1.13) Group Never-HCT Reference  
 Group Pre- vs never-HCT 2.06 (1.40-3.04) <.001 
 Group Post- vs never-HCT 1.27 (0.70-2.32) .4344 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.93 (0.87-0.99) .0346 
 Group change over time∗  Post- vs never-HCT 1.00 (0.95-1.05) .9789 
Perceived social support (ENRICHD social support inventory) (greater than mean - 0.5 standard) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.76 (1.21-2.57) .0033 
 Group Post- vs never-HCT 1.31 (0.76-2.25) .3341 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.95 (0.89-1.02) .1838 
 Group change over time∗  Post- vs never-HCT 1.00 (0.96-1.04) .97 
Instrumental activities of daily living (=14) Group Never-HCT Reference  
 Group Pre- vs never-HCT 0.98 (0.71-1.36) .9177 
 Group Post- vs never-HCT 0.39 (0.24-0.63) <.001 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.99 (0.93-1.06) .8508 
 Group change over time∗  Post- vs never-HCT 1.02 (0.98-1.07) .3102 
ADL (=14) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.67 (1.17-2.37) .0043 
 Group Post- vs never-HCT 0.98 (0.58-1.67) .9542 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.98 (0.91-1.05) .4973 
 Group change over time∗  Post- vs never-HCT 1.01 (0.96-1.06) .7107 
Frailty (4-MWT) (≥0.8 m/s) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.33 (0.94-1.89) .1119 
 Group Post- vs never-HCT 2.14 (1.14-3.99) .0171 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 1.11 (0.97-1.27) .1222 
 Group change over time∗  Post- vs never-HCT 0.95 (0.89-1.01) .1092 
Frailty (Fried frailty index) (=0) Group Never-HCT Reference  
 Group Pre- vs never-HCT 1.22 (0.77-1.93) .4019 
 Group Post- vs never-HCT 3.69 (1.48-9.23) .0051 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.93 (0.81-1.06) .2599 
 Group change over time∗  Post- vs never-HCT 0.91 (0.81-1.02) .1022 
Performance status (KPS) (>70) Group Never-HCT Reference  
 Group Pre- vs never-HCT 3.00 (2.01-4.46) <.001 
 Group Post- vs never-HCT 0.66 (0.41-1.05) .0804 
 Group change over time∗  Never-HCT Reference  
 Group change over time∗  Pre- vs never-HCT 0.94 (0.88-1.00) .0464 
 Group change over time∗  Post- vs never-HCT 1.00 (0.96-1.04) .9939 
∗

Adjusted for age group, sex, comorbidity score group per AML composite model, disease type (MDS/myeloproliferative disorder or AML), and induction treatment regimen intensity as appropriate.

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