Demographic and treatment characteristics of survivors of AML, overall and by treatment group
. | Treatment group . | Overall . | |||||||
---|---|---|---|---|---|---|---|---|---|
HCT . | Chemo + CRT . | Chemo-only . | |||||||
n . | % . | n . | % . | n . | % . | N . | % . | ||
Sex | Female | 164 | 48.4 | 50 | 53.8 | 222 | 52.4 | 436 | 50.9 |
Age at diagnosis, y | 0-4 | 121 | 35.7 | 43 | 46.2 | 216 | 50.9 | 380 | 44.4 |
5-9 | 74 | 21.8 | 15 | 16.1 | 71 | 16.7 | 160 | 18.7 | |
10-14 | 84 | 24.8 | 23 | 24.7 | 72 | 17.0 | 179 | 20.9 | |
15-20 | 60 | 17.7 | 12 | 12.9 | 65 | 15.3 | 137 | 16.0 | |
Down syndrome | Yes | 1 | 0.3 | 3 | 3.2 | 81 | 19.1 | 85 | 9.9 |
Race/ethnicity | White non-Hispanic | 256 | 75.5 | 75 | 80.6 | 313 | 73.8 | 644 | 75.2 |
White Hispanic | 19 | 5.6 | 7 | 7.5 | 25 | 5.9 | 51 | 6.0 | |
Black | 22 | 6.5 | 6 | 6.5 | 37 | 8.7 | 65 | 7.6 | |
Other | 39 | 11.5 | 3 | 3.2 | 43 | 10.1 | 85 | 9.9 | |
Unknown | 3 | 0.9 | 2 | 2.2 | 6 | 1.4 | 11 | 1.3 | |
Decade of diagnosis | 1970-79 | 18 | 5.3 | 31 | 33.3 | 61 | 14.4 | 110 | 12.9 |
1980-89 | 120 | 35.4 | 55 | 59.1 | 142 | 33.5 | 317 | 37.0 | |
1990-99 | 201 | 59.3 | 7 | 7.5 | 221 | 52.1 | 429 | 50.1 | |
Anthracyclines (doxorubicin-equivalent dose), mg/m2 | None | 15 | 4.8 | 7 | 8.4 | 29 | 7.2 | 51 | 6.0 |
>0-100 | 89 | 28.3 | 18 | 21.7 | 46 | 11.5 | 153 | 17.9 | |
>100-249 | 162 | 51.4 | 31 | 37.3 | 235 | 58.6 | 428 | 50.0 | |
≥250 | 49 | 15.6 | 27 | 32.5 | 91 | 22.7 | 167 | 19.5 | |
Epipodophyllotoxins, mg/m2 | None | 80 | 25.3 | 59 | 64.1 | 133 | 32.4 | 272 | 31.8 |
>0-1000 | 106 | 33.5 | 3 | 3.3 | 109 | 26.6 | 218 | 25.5 | |
>1000-3999 | 116 | 36.7 | 14 | 15.2 | 136 | 33.2 | 266 | 31.1 | |
≥4000 | 14 | 4.4 | 16 | 17.4 | 32 | 7.8 | 62 | 7.2 | |
Alkylating agents (cyclophosphamide equivalent dose), mg/m2 | None | 73 | 24.9 | 29 | 34.1 | 255 | 61.9 | 357 | 41.7 |
>0-3999 | 81 | 27.6 | 12 | 14.1 | 101 | 24.5 | 194 | 22.7 | |
≥4000-7999 | 57 | 19.5 | 26 | 30.6 | 31 | 7.5 | 114 | 13.3 | |
≥8000 | 82 | 28.0 | 18 | 21.2 | 25 | 6.1 | 125 | 14.6 | |
Any radiation | Yes | 192 | 56.6 | 93 | 100.0 | 6 | 1.4 | 291 | 34.0 |
TBI | Yes | 157 | 49.5 | 0 | 0.0 | 0 | 0.0 | 157 | 18.3 |
CRT (not TBI) | Yes | 15 | 9.4 | 93 | 100.0 | 0 | 0.0 | 108 | 12.6 |
Other site radiation (not TBI) | Yes | 12 | 7.5 | 18 | 19.4 | 6 | 1.4 | 36 | 4.2 |
HCT | No HCT | 0 | 0.0 | 93 | 100.0 | 424 | 100.0 | 517 | 60.4 |
Allogeneic | 238 | 70.2 | 0 | 0.0 | 0 | 0.0 | 238 | 27.8 | |
Autologous | 81 | 23.9 | 0 | 0.0 | 0 | 0.0 | 81 | 9.5 | |
HCT type unknown | 20 | 5.9 | 0 | 0.0 | 0 | 0.0 | 20 | 2.3 | |
Chronic GVHD, by grade∗ (among survivors treated with allogeneic HCT) | None | 77 | 32.4 | 93 | 100.0 | 424 | 100.0 | 594 | 69.4 |
Limited | 23 | 9.7 | 0 | 0.0 | 0 | 0.0 | 23 | 2.7 | |
Extensive | 12 | 5.0 | 0 | 0.0 | 0 | 0.0 | 12 | 1.4 | |
Unknown grade | 2 | 0.8 | 0 | 0.0 | 0 | 0.0 | 2 | 0.2 | |
Unavailable data | 124 | 52.1 | 0 | 0.0 | 0 | 0.0 | 124 | 14.5 | |
Vital status | Alive | 274 | 80.8 | 79 | 84.9 | 393 | 92.7 | 746 | 87.1 |
Follow-up, y | 5-9 | 24 | 7.1 | 1 | 1.1 | 8 | 1.9 | 33 | 3.9 |
10-19 | 91 | 26.9 | 11 | 11.8 | 110 | 26.0 | 212 | 24.7 | |
20-29 | 181 | 53.4 | 30 | 32.3 | 200 | 47.1 | 411 | 48.0 | |
≥30 | 43 | 12.6 | 51 | 54.8 | 106 | 25.0 | 200 | 23.4 |
. | Treatment group . | Overall . | |||||||
---|---|---|---|---|---|---|---|---|---|
HCT . | Chemo + CRT . | Chemo-only . | |||||||
n . | % . | n . | % . | n . | % . | N . | % . | ||
Sex | Female | 164 | 48.4 | 50 | 53.8 | 222 | 52.4 | 436 | 50.9 |
Age at diagnosis, y | 0-4 | 121 | 35.7 | 43 | 46.2 | 216 | 50.9 | 380 | 44.4 |
5-9 | 74 | 21.8 | 15 | 16.1 | 71 | 16.7 | 160 | 18.7 | |
10-14 | 84 | 24.8 | 23 | 24.7 | 72 | 17.0 | 179 | 20.9 | |
15-20 | 60 | 17.7 | 12 | 12.9 | 65 | 15.3 | 137 | 16.0 | |
Down syndrome | Yes | 1 | 0.3 | 3 | 3.2 | 81 | 19.1 | 85 | 9.9 |
Race/ethnicity | White non-Hispanic | 256 | 75.5 | 75 | 80.6 | 313 | 73.8 | 644 | 75.2 |
White Hispanic | 19 | 5.6 | 7 | 7.5 | 25 | 5.9 | 51 | 6.0 | |
Black | 22 | 6.5 | 6 | 6.5 | 37 | 8.7 | 65 | 7.6 | |
Other | 39 | 11.5 | 3 | 3.2 | 43 | 10.1 | 85 | 9.9 | |
Unknown | 3 | 0.9 | 2 | 2.2 | 6 | 1.4 | 11 | 1.3 | |
Decade of diagnosis | 1970-79 | 18 | 5.3 | 31 | 33.3 | 61 | 14.4 | 110 | 12.9 |
1980-89 | 120 | 35.4 | 55 | 59.1 | 142 | 33.5 | 317 | 37.0 | |
1990-99 | 201 | 59.3 | 7 | 7.5 | 221 | 52.1 | 429 | 50.1 | |
Anthracyclines (doxorubicin-equivalent dose), mg/m2 | None | 15 | 4.8 | 7 | 8.4 | 29 | 7.2 | 51 | 6.0 |
>0-100 | 89 | 28.3 | 18 | 21.7 | 46 | 11.5 | 153 | 17.9 | |
>100-249 | 162 | 51.4 | 31 | 37.3 | 235 | 58.6 | 428 | 50.0 | |
≥250 | 49 | 15.6 | 27 | 32.5 | 91 | 22.7 | 167 | 19.5 | |
Epipodophyllotoxins, mg/m2 | None | 80 | 25.3 | 59 | 64.1 | 133 | 32.4 | 272 | 31.8 |
>0-1000 | 106 | 33.5 | 3 | 3.3 | 109 | 26.6 | 218 | 25.5 | |
>1000-3999 | 116 | 36.7 | 14 | 15.2 | 136 | 33.2 | 266 | 31.1 | |
≥4000 | 14 | 4.4 | 16 | 17.4 | 32 | 7.8 | 62 | 7.2 | |
Alkylating agents (cyclophosphamide equivalent dose), mg/m2 | None | 73 | 24.9 | 29 | 34.1 | 255 | 61.9 | 357 | 41.7 |
>0-3999 | 81 | 27.6 | 12 | 14.1 | 101 | 24.5 | 194 | 22.7 | |
≥4000-7999 | 57 | 19.5 | 26 | 30.6 | 31 | 7.5 | 114 | 13.3 | |
≥8000 | 82 | 28.0 | 18 | 21.2 | 25 | 6.1 | 125 | 14.6 | |
Any radiation | Yes | 192 | 56.6 | 93 | 100.0 | 6 | 1.4 | 291 | 34.0 |
TBI | Yes | 157 | 49.5 | 0 | 0.0 | 0 | 0.0 | 157 | 18.3 |
CRT (not TBI) | Yes | 15 | 9.4 | 93 | 100.0 | 0 | 0.0 | 108 | 12.6 |
Other site radiation (not TBI) | Yes | 12 | 7.5 | 18 | 19.4 | 6 | 1.4 | 36 | 4.2 |
HCT | No HCT | 0 | 0.0 | 93 | 100.0 | 424 | 100.0 | 517 | 60.4 |
Allogeneic | 238 | 70.2 | 0 | 0.0 | 0 | 0.0 | 238 | 27.8 | |
Autologous | 81 | 23.9 | 0 | 0.0 | 0 | 0.0 | 81 | 9.5 | |
HCT type unknown | 20 | 5.9 | 0 | 0.0 | 0 | 0.0 | 20 | 2.3 | |
Chronic GVHD, by grade∗ (among survivors treated with allogeneic HCT) | None | 77 | 32.4 | 93 | 100.0 | 424 | 100.0 | 594 | 69.4 |
Limited | 23 | 9.7 | 0 | 0.0 | 0 | 0.0 | 23 | 2.7 | |
Extensive | 12 | 5.0 | 0 | 0.0 | 0 | 0.0 | 12 | 1.4 | |
Unknown grade | 2 | 0.8 | 0 | 0.0 | 0 | 0.0 | 2 | 0.2 | |
Unavailable data | 124 | 52.1 | 0 | 0.0 | 0 | 0.0 | 124 | 14.5 | |
Vital status | Alive | 274 | 80.8 | 79 | 84.9 | 393 | 92.7 | 746 | 87.1 |
Follow-up, y | 5-9 | 24 | 7.1 | 1 | 1.1 | 8 | 1.9 | 33 | 3.9 |
10-19 | 91 | 26.9 | 11 | 11.8 | 110 | 26.0 | 212 | 24.7 | |
20-29 | 181 | 53.4 | 30 | 32.3 | 200 | 47.1 | 411 | 48.0 | |
≥30 | 43 | 12.6 | 51 | 54.8 | 106 | 25.0 | 200 | 23.4 |
Chronic GVHD data provided through linkage to the CIBMTR database; no data available for survivors diagnosed before 1980 and limited to those included in CIBMTR thereafter; percentages presented relative to 238 allogeneic transplant recipients.