Patient demographics and baseline characteristics
| . | Group I: single ventricle . | Group II: neonatal biventricular . | Group III: without CPB . | Group IV: nonneonatal biventricular . | Entire cohort . |
|---|---|---|---|---|---|
| n (% of all) | 14 (21.5) | 17 (26.2) | 10 (15.4) | 24 (36.9) | 65 (100) |
| Sex male | 9 (64.3) | 10 (58.8) | 5 (50) | 15 (62.5) | 39 (60) |
| Age, d | 14 (9-48) | 12 (8-18) | 44 (15-108) | 167 (114-222) | 46 (12-151) |
| Weight, kg | 3.6 (3.1-3.9) | 3.3 (2.9-3.7) | 3.6 (2.0-5.6) | 6.1 (4.1-6.9) | 3.9 (3.1-5.8) |
| Performed surgeries | |||||
| mBTS or PDA-stent, ASE, and bipulmonary banding | 3 (4.6) | – | – | – | 3 (4.6) |
| mBTS implantation | 3 (4.6) | – | – | – | 3 (4.6) |
| Norwood type procedure | 8 (12.4) | – | – | – | 8 (12.4) |
| Arterial switch | – | 9 (13.8) | – | – | 9 (13.8) |
| Aortic valve repair | – | 2 (3.1) | – | 1 (1.5) | 3 (4.6) |
| Aortic coarctation repair | – | – | 5 (7.7) | – | 5 (7.7) |
| Pulmonary banding | – | – | 2 (3.1) | – | 2 (3.1) |
| PDA ligation | – | – | 3 (4.6) | – | 3 (4.6) |
| TOF repair | – | – | – | 10 (15.4) | 10 (15.4) |
| Biventricular repair (others) | – | 6 (9.2) | – | 13 (20) | 19 (29.2) |
| CPB time, min | 116 (77-163) | 150 (94-206) | – | 109 (75-161) | 107 (53-164) |
| ACC time, min | 63 (26-89) | 114 (56-164) | 10 (0-22) | 77 (58-104) | 67 (27-109) |
| Reperfusion, min | 40 (23-76) | 18 (10-27) | – | 11 (6-17) | 13 (6.8-27) |
| Minimal temperature (% within group) | |||||
| Normothermia | 2 (3.1) | – | 9 (13.8) | 9 (13.8) | 20 (30.8) |
| 32°C-36°C | 5 (7.7) | 13 (20) | 1 (1.5) | 15 (23.1) | 34 (52.3) |
| Below 32°C | 7 (10.8) | 4 (6.2) | – | – | 11 (16.9) |
| Median, °C | 32 (28-35) | 32 (31.5-33.5) | 37 (36-37) | 35 (34-36.3) | 34 (32-36) |
| Postoperative stay in ICU, d | 13 (10-46) | 9 (7-17) | 4 (3-10) | 8 (5-10) | 9 (6-13) |
| Laboratory parameters at baseline | |||||
| aPTT, s | 33.5 (29.8-41) | 34.5 (32-36.8) | 33.5 (31.2-38.8) | 32 (30-33.8) | 33 (30.3-35.0) |
| INR | 1.13 (1.11-1.18) | 1.16 (1.11-1.28) | 1.13 (1.05-1.21) | 1.15 (1.07-1.22) | 1.15 (1.09-1.22) |
| Fibrinogen, mg/dL | 202 (135-269) | 185 (116-239) | 208 (180-226) | 178 (149-218) | 191 (149-229) |
| Platelets, ×103/μL | 288 (241-441) | 356 (210-483) | 315 (249-440) | 380 (317-533) | 346 (254-511) |
| Hemoglobin, mg/dL | 15.2 (13.5-16.7) | 14.2 (12.9-15.5) | 12.2 (11.0-13.1) | 12.7 (11.0-14.7) | 13.2 (11.9-15.2) |
| Antithrombin, % | 66 (58-101) | 64 (46-72) | 66 (49-75) | 76 (68-91) | 69 (60-81) |
| FVIII:C, % | 89 (74-118) | 99 (82-105) | 84 (79-120) | 78 (64-114) | 85 (72-109) |
| VWF:Ag, % | 108 (91-125) | 108 (81-130) | 118 (101-190) | 89 (58-114) | 105 (83-126) |
| . | Group I: single ventricle . | Group II: neonatal biventricular . | Group III: without CPB . | Group IV: nonneonatal biventricular . | Entire cohort . |
|---|---|---|---|---|---|
| n (% of all) | 14 (21.5) | 17 (26.2) | 10 (15.4) | 24 (36.9) | 65 (100) |
| Sex male | 9 (64.3) | 10 (58.8) | 5 (50) | 15 (62.5) | 39 (60) |
| Age, d | 14 (9-48) | 12 (8-18) | 44 (15-108) | 167 (114-222) | 46 (12-151) |
| Weight, kg | 3.6 (3.1-3.9) | 3.3 (2.9-3.7) | 3.6 (2.0-5.6) | 6.1 (4.1-6.9) | 3.9 (3.1-5.8) |
| Performed surgeries | |||||
| mBTS or PDA-stent, ASE, and bipulmonary banding | 3 (4.6) | – | – | – | 3 (4.6) |
| mBTS implantation | 3 (4.6) | – | – | – | 3 (4.6) |
| Norwood type procedure | 8 (12.4) | – | – | – | 8 (12.4) |
| Arterial switch | – | 9 (13.8) | – | – | 9 (13.8) |
| Aortic valve repair | – | 2 (3.1) | – | 1 (1.5) | 3 (4.6) |
| Aortic coarctation repair | – | – | 5 (7.7) | – | 5 (7.7) |
| Pulmonary banding | – | – | 2 (3.1) | – | 2 (3.1) |
| PDA ligation | – | – | 3 (4.6) | – | 3 (4.6) |
| TOF repair | – | – | – | 10 (15.4) | 10 (15.4) |
| Biventricular repair (others) | – | 6 (9.2) | – | 13 (20) | 19 (29.2) |
| CPB time, min | 116 (77-163) | 150 (94-206) | – | 109 (75-161) | 107 (53-164) |
| ACC time, min | 63 (26-89) | 114 (56-164) | 10 (0-22) | 77 (58-104) | 67 (27-109) |
| Reperfusion, min | 40 (23-76) | 18 (10-27) | – | 11 (6-17) | 13 (6.8-27) |
| Minimal temperature (% within group) | |||||
| Normothermia | 2 (3.1) | – | 9 (13.8) | 9 (13.8) | 20 (30.8) |
| 32°C-36°C | 5 (7.7) | 13 (20) | 1 (1.5) | 15 (23.1) | 34 (52.3) |
| Below 32°C | 7 (10.8) | 4 (6.2) | – | – | 11 (16.9) |
| Median, °C | 32 (28-35) | 32 (31.5-33.5) | 37 (36-37) | 35 (34-36.3) | 34 (32-36) |
| Postoperative stay in ICU, d | 13 (10-46) | 9 (7-17) | 4 (3-10) | 8 (5-10) | 9 (6-13) |
| Laboratory parameters at baseline | |||||
| aPTT, s | 33.5 (29.8-41) | 34.5 (32-36.8) | 33.5 (31.2-38.8) | 32 (30-33.8) | 33 (30.3-35.0) |
| INR | 1.13 (1.11-1.18) | 1.16 (1.11-1.28) | 1.13 (1.05-1.21) | 1.15 (1.07-1.22) | 1.15 (1.09-1.22) |
| Fibrinogen, mg/dL | 202 (135-269) | 185 (116-239) | 208 (180-226) | 178 (149-218) | 191 (149-229) |
| Platelets, ×103/μL | 288 (241-441) | 356 (210-483) | 315 (249-440) | 380 (317-533) | 346 (254-511) |
| Hemoglobin, mg/dL | 15.2 (13.5-16.7) | 14.2 (12.9-15.5) | 12.2 (11.0-13.1) | 12.7 (11.0-14.7) | 13.2 (11.9-15.2) |
| Antithrombin, % | 66 (58-101) | 64 (46-72) | 66 (49-75) | 76 (68-91) | 69 (60-81) |
| FVIII:C, % | 89 (74-118) | 99 (82-105) | 84 (79-120) | 78 (64-114) | 85 (72-109) |
| VWF:Ag, % | 108 (91-125) | 108 (81-130) | 118 (101-190) | 89 (58-114) | 105 (83-126) |
Values are presented as n (%) or median (IQR).
–, 0%; aPTT, activated partial thromboplastin time; ASE, atrioseptectomy; ICU, intensive care unit; INR, international normalized ratio; mBTS, modified Blalock-Taussig shunt; TOF, tetralogy of Fallot.