Incidence of treatment-emergent adverse events occurring in at least 5% of patients in any study group
| Event∗ . | No. of patients (%) . | |
|---|---|---|
| Rivipansel (N = 162) . | Placebo (N = 158) . | |
| Blood and lymphatic system disorders | ||
| Anemia† | 27 (16.7) | 26 (16.5) |
| Sickle cell anemia with crisis‡ | 43 (26.5) | 47 (29.7) |
| Gastrointestinal disorders | ||
| Abdominal pain | 9 (5.6) | 6 (3.8) |
| Constipation | 30 (18.5) | 21 (13.3) |
| Nausea | 26 (16.0) | 27 (17.1) |
| Vomiting | 17 (10.5) | 16 (10.1) |
| General disorders and administration site conditions | ||
| Chest pain | 9 (5.6) | 8 (5.1) |
| Pyrexia | 29 (17.9) | 33 (20.9) |
| Nervous system disorders | ||
| Dizziness | 9 (5.6) | 4 (2.5) |
| Headache | 19 (11.7) | 30 (19.0) |
| Musculoskeletal and connective tissue disorders | ||
| Pain in extremity | 9 (5.6) | 8 (5.1) |
| Onset during hospitalization | 3 (1.9) | 3 (1.9) |
| Onset after hospital discharge | 6 (3.7) | 5 (3.2) |
| Respiratory, thoracic, and mediastinal disorders | ||
| Acute chest syndrome | 9 (5.6) | 10 (6.3) |
| Dyspnea | 10 (6.2) | 3 (1.9) |
| Hypoxia | 9 (5.6) | 8 (5.1) |
| Skin and subcutaneous tissue disorders | ||
| Pruritus | 24 (14.8) | 17 (10.8) |
| Rash | 9 (5.6) | 6 (3.8) |
| Event∗ . | No. of patients (%) . | |
|---|---|---|
| Rivipansel (N = 162) . | Placebo (N = 158) . | |
| Blood and lymphatic system disorders | ||
| Anemia† | 27 (16.7) | 26 (16.5) |
| Sickle cell anemia with crisis‡ | 43 (26.5) | 47 (29.7) |
| Gastrointestinal disorders | ||
| Abdominal pain | 9 (5.6) | 6 (3.8) |
| Constipation | 30 (18.5) | 21 (13.3) |
| Nausea | 26 (16.0) | 27 (17.1) |
| Vomiting | 17 (10.5) | 16 (10.1) |
| General disorders and administration site conditions | ||
| Chest pain | 9 (5.6) | 8 (5.1) |
| Pyrexia | 29 (17.9) | 33 (20.9) |
| Nervous system disorders | ||
| Dizziness | 9 (5.6) | 4 (2.5) |
| Headache | 19 (11.7) | 30 (19.0) |
| Musculoskeletal and connective tissue disorders | ||
| Pain in extremity | 9 (5.6) | 8 (5.1) |
| Onset during hospitalization | 3 (1.9) | 3 (1.9) |
| Onset after hospital discharge | 6 (3.7) | 5 (3.2) |
| Respiratory, thoracic, and mediastinal disorders | ||
| Acute chest syndrome | 9 (5.6) | 10 (6.3) |
| Dyspnea | 10 (6.2) | 3 (1.9) |
| Hypoxia | 9 (5.6) | 8 (5.1) |
| Skin and subcutaneous tissue disorders | ||
| Pruritus | 24 (14.8) | 17 (10.8) |
| Rash | 9 (5.6) | 6 (3.8) |