Population PK parameters of the final model and 1000 bootstrap runs
| Final population PK model . | 1000 bootstrap run results . | ||||
|---|---|---|---|---|---|
| . | Mean value . | RSE (%) . | Shrinkage (%) . | Median value . | 95% CI . |
| CLpop (L per day) | 0.214 | 11 | 0.210 | 0.11-0.32 | |
| Exponent WTmed on CLpop (fixed) | 0.75 | 0.75 | |||
| Linear function LYmed on CLpop | 0.8 | 29 | 0.88 | 0.09-2.85 | |
| Vdpop (L) | 0.985 | 14 | 0.994 | 0.717-1.32 | |
| Exponent WTmed on Vd (fixed) | 1 | 0.75 | |||
| K21/d | 2.63 | 16 | 2.52 | 1.33-3.30 | |
| Tmax (mg per day) | 22.3 | 29 | 22.17 | 8.49-38.02 | |
| Tm (μg/mL) | 2.23 | 42 | 2.15 | 1.25-5.74 | |
| Vmax (mg per day) | 0.0438 | 23 | 0.0485 | 0.026-0.255 | |
| Km (μg/mL) | 0.633 | 19 | 0.605 | 0.229-8.142 | |
| IIV | |||||
| CL (CV%) | 74.4 | 14 | 0 | 73.1 | 53.5-95.7 |
| Vd (CV%) | 41.5 | 18 | 21 | 42.2 | 25.6-58.2 |
| Tm (CV%) | 114.5 | 13 | 7 | 111.9 | 86.6-144.4 |
| Km (CV%) | 195.4 | 29 | 58 | 162.3 | 77.0-586.0 |
| Random residual variability | |||||
| Proportional (CV%) | 27.9 | 7 | 9 | 27.6 | 24.0-32.4 |
| Additive (μg/mL) | 0.0231 | 23 | 9 | 0.0225 | 0.0006-0.034 |
| Final population PK model . | 1000 bootstrap run results . | ||||
|---|---|---|---|---|---|
| . | Mean value . | RSE (%) . | Shrinkage (%) . | Median value . | 95% CI . |
| CLpop (L per day) | 0.214 | 11 | 0.210 | 0.11-0.32 | |
| Exponent WTmed on CLpop (fixed) | 0.75 | 0.75 | |||
| Linear function LYmed on CLpop | 0.8 | 29 | 0.88 | 0.09-2.85 | |
| Vdpop (L) | 0.985 | 14 | 0.994 | 0.717-1.32 | |
| Exponent WTmed on Vd (fixed) | 1 | 0.75 | |||
| K21/d | 2.63 | 16 | 2.52 | 1.33-3.30 | |
| Tmax (mg per day) | 22.3 | 29 | 22.17 | 8.49-38.02 | |
| Tm (μg/mL) | 2.23 | 42 | 2.15 | 1.25-5.74 | |
| Vmax (mg per day) | 0.0438 | 23 | 0.0485 | 0.026-0.255 | |
| Km (μg/mL) | 0.633 | 19 | 0.605 | 0.229-8.142 | |
| IIV | |||||
| CL (CV%) | 74.4 | 14 | 0 | 73.1 | 53.5-95.7 |
| Vd (CV%) | 41.5 | 18 | 21 | 42.2 | 25.6-58.2 |
| Tm (CV%) | 114.5 | 13 | 7 | 111.9 | 86.6-144.4 |
| Km (CV%) | 195.4 | 29 | 58 | 162.3 | 77.0-586.0 |
| Random residual variability | |||||
| Proportional (CV%) | 27.9 | 7 | 9 | 27.6 | 24.0-32.4 |
| Additive (μg/mL) | 0.0231 | 23 | 9 | 0.0225 | 0.0006-0.034 |
K21, transfer rate constants connecting compartments; Tmax, maximum transport rate of distribution toward peripheral compartment; Tm, Michaelis–Menten constant saturable distribution toward peripheral compartment; Vmax, maximum elimination rate; Km, concentration at which the elimination pathway is half saturated; CV%, percentage coefficient of variation.