Pathologic features of 5 tFL-PMBLsig-pos cases
| . | 1 . | 2 . | 3 . | 4 . | 5 . |
|---|---|---|---|---|---|
| EX00406 . | EX00408 . | EX004010 . | FL1179T2 . | FL1122T2 . | |
| Histology | Centroblasts | Centroblasts | Centroblasts | Centroblasts | Centroblasts |
| Fine sclerosis | Yes | Yes | Yes | Yes | Yes |
| Concurrent FL (histologic grade) | No | Yes (3A) | Yes (1-2) | No | No |
| CD10 | + | + | − | − | NA |
| BCL6 | + | + | + | + | NA |
| IRF4/MUM1 | + | − | − | NA | NA |
| CD23 | − | + | + | + | − |
| CD30 | − | − | + | − | − |
| CD200 | − | + | − | − | − |
| CD273/PDL2 | − | − | − | − | − |
| MAL | + | + | − | + | + |
| Ki-67 | 80% | 50% | NA | 70% | NA |
| EBV-ISH (EBER) | − | − | NA | NA | NA |
| MYC rearrangement∗ | − | − | − | − | − |
| BCL2 rearrangement∗ | + | − | − | − | + |
| BCL6 rearrangement∗ | + | − | + | − | − |
| COO (Lymph2Cx) | GCB | GCB | UNC | GCB | GCB |
| . | 1 . | 2 . | 3 . | 4 . | 5 . |
|---|---|---|---|---|---|
| EX00406 . | EX00408 . | EX004010 . | FL1179T2 . | FL1122T2 . | |
| Histology | Centroblasts | Centroblasts | Centroblasts | Centroblasts | Centroblasts |
| Fine sclerosis | Yes | Yes | Yes | Yes | Yes |
| Concurrent FL (histologic grade) | No | Yes (3A) | Yes (1-2) | No | No |
| CD10 | + | + | − | − | NA |
| BCL6 | + | + | + | + | NA |
| IRF4/MUM1 | + | − | − | NA | NA |
| CD23 | − | + | + | + | − |
| CD30 | − | − | + | − | − |
| CD200 | − | + | − | − | − |
| CD273/PDL2 | − | − | − | − | − |
| MAL | + | + | − | + | + |
| Ki-67 | 80% | 50% | NA | 70% | NA |
| EBV-ISH (EBER) | − | − | NA | NA | NA |
| MYC rearrangement∗ | − | − | − | − | − |
| BCL2 rearrangement∗ | + | − | − | − | + |
| BCL6 rearrangement∗ | + | − | + | − | − |
| COO (Lymph2Cx) | GCB | GCB | UNC | GCB | GCB |
The symbol + indicates positive and − indicates negative.
NA, not available; UNC, unclassified.
MYC, BCL2, and BCL6 rearrangements detected by fluorescence in situ hybridization.