Table 5.

Multivariable logistic regression model for clinical relapse

VariableUnivariable analysisMultivariable analysis
OR95% CIPOR95% CIP
Male sex 1.09 0.87-1.36 .44 1.49 1.02-2.18 .04 
Age older than 65 y 0.94 0.76-1.18 .60 1.05 0.72-1.54 .80 
At diagnosis:       
PCL index ≥2% 1.54 1.08-2.20 .02 1.58 1.02-2.45 .04 
High-risk FISH 1.63 1.21-2.18 .001 1.36 0.88-2.10 .17 
Calcium >11 mg/dL 1.44 1.01-2.06 .04 0.74 0.38-1.44 .37 
Non-secretory disease 2.79 1.52-5.11 <.001 1.74 0.59-5.18 .32 
EMD 2.06 1.50-2.84 <.001 1.84 1.08-3.13 .03 
Novel agents in first-line therapy 0.60 0.45-0.79 <.001 0.83 0.44-1.54 .55 
PI + IMiD–based first-line therapy 1.01 0.78-1.32 .93 —  — 
Lenalidomide maintenance after first-line therapy 0.70 0.54-0.90 .007 0.82 0.48-1.39 .46 
First-line ASCT 0.74 0.60-0.92 .008 0.88 0.59-1.33 .55 
VGPR or better after first-line therapy 0.75 0.60-0.94 .01 0.62 0.43-0.91 .02 
ISS stage III at diagnosis 1.14 0.89-1.46 .3 — — — 
VariableUnivariable analysisMultivariable analysis
OR95% CIPOR95% CIP
Male sex 1.09 0.87-1.36 .44 1.49 1.02-2.18 .04 
Age older than 65 y 0.94 0.76-1.18 .60 1.05 0.72-1.54 .80 
At diagnosis:       
PCL index ≥2% 1.54 1.08-2.20 .02 1.58 1.02-2.45 .04 
High-risk FISH 1.63 1.21-2.18 .001 1.36 0.88-2.10 .17 
Calcium >11 mg/dL 1.44 1.01-2.06 .04 0.74 0.38-1.44 .37 
Non-secretory disease 2.79 1.52-5.11 <.001 1.74 0.59-5.18 .32 
EMD 2.06 1.50-2.84 <.001 1.84 1.08-3.13 .03 
Novel agents in first-line therapy 0.60 0.45-0.79 <.001 0.83 0.44-1.54 .55 
PI + IMiD–based first-line therapy 1.01 0.78-1.32 .93 —  — 
Lenalidomide maintenance after first-line therapy 0.70 0.54-0.90 .007 0.82 0.48-1.39 .46 
First-line ASCT 0.74 0.60-0.92 .008 0.88 0.59-1.33 .55 
VGPR or better after first-line therapy 0.75 0.60-0.94 .01 0.62 0.43-0.91 .02 
ISS stage III at diagnosis 1.14 0.89-1.46 .3 — — — 

OR, odds ratio.

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