Toxicity across dose quartiles
| Characteristic . | Dose, × 106 CAR T cells per kg . | P∗ . | |||
|---|---|---|---|---|---|
| 0-1.3 n = 48 . | 1.3-1.7 n = 46 . | 1.7-2.4 n = 43 . | 2.4-5.1 n = 43 . | ||
| Did patient develop CRS? | 25 (52) | 28 (61) | 26 (60) | 28 (65) | .2 |
| Did patient experience neurotoxicity? | 11 (23) | 10 (22) | 7 (16) | 11 (26) | >.9 |
| Unknown | 1 | 1 | 0 | 1 | |
| Grade ≥3 CRS | 13 (27) | 10 (22) | 8 (19) | 6 (14) | .11 |
| Unknown | 0 | 1 | 0 | 0 | |
| Grade ≥3 neurotoxicity | 2 (4.3) | 4 (9.1) | 1 (2.3) | 4 (9.5) | .6 |
| Unknown | 1 | 2 | 0 | 1 | |
| Treatment of neurotoxicity (choice, steroids [systemic]) | .2 | ||||
| Checked | 2 (4.2) | 3 (6.5) | 1 (2.3) | 6 (14) | |
| Unchecked | 46 (96) | 43 (93) | 42 (98) | 37 (86) | |
| Treatment of neurotoxicity (choice, IT steroids) | |||||
| Unchecked | 48 (100) | 46 (100) | 43 (100) | 43 (100) | |
| Treatment of neurotoxicity (choice, tocilizumab) | .6 | ||||
| Checked | 2 (4.2) | 2 (4.3) | 0 (0) | 2 (4.7) | |
| Unchecked | 46 (96) | 44 (96) | 43 (100) | 41 (95) | |
| Characteristic . | Dose, × 106 CAR T cells per kg . | P∗ . | |||
|---|---|---|---|---|---|
| 0-1.3 n = 48 . | 1.3-1.7 n = 46 . | 1.7-2.4 n = 43 . | 2.4-5.1 n = 43 . | ||
| Did patient develop CRS? | 25 (52) | 28 (61) | 26 (60) | 28 (65) | .2 |
| Did patient experience neurotoxicity? | 11 (23) | 10 (22) | 7 (16) | 11 (26) | >.9 |
| Unknown | 1 | 1 | 0 | 1 | |
| Grade ≥3 CRS | 13 (27) | 10 (22) | 8 (19) | 6 (14) | .11 |
| Unknown | 0 | 1 | 0 | 0 | |
| Grade ≥3 neurotoxicity | 2 (4.3) | 4 (9.1) | 1 (2.3) | 4 (9.5) | .6 |
| Unknown | 1 | 2 | 0 | 1 | |
| Treatment of neurotoxicity (choice, steroids [systemic]) | .2 | ||||
| Checked | 2 (4.2) | 3 (6.5) | 1 (2.3) | 6 (14) | |
| Unchecked | 46 (96) | 43 (93) | 42 (98) | 37 (86) | |
| Treatment of neurotoxicity (choice, IT steroids) | |||||
| Unchecked | 48 (100) | 46 (100) | 43 (100) | 43 (100) | |
| Treatment of neurotoxicity (choice, tocilizumab) | .6 | ||||
| Checked | 2 (4.2) | 2 (4.3) | 0 (0) | 2 (4.7) | |
| Unchecked | 46 (96) | 44 (96) | 43 (100) | 41 (95) | |
Data are given as n (%).
IT, intrathecal.
χ2 test of linear-by-linear association; Fisher exact test.