For associations of BRAF^V600E, BRAF^V600E+ (n = 191) vs BRAF^V600E− (n = 186) patients were compared. For associations of MAP2K1 or BRAF exon 12 mutations, assignment is based on the statistical comparison of patients with MAP2K1 mutations (n = 54) or BRAF exon 12 mutations (n = 39) with patients with BRAF^V600E, respectively. Associations of MAP2K1 or BRAF exon 12 mutations required (1) a difference with patients with BRAF^V600E resulting in a Fisher exact test P < .05 (for potential associations) or P < 0.00125 (for significant associations) and (2) a difference between patients with MAP2K1 and BRAF exon 12 mutations resulting in a Fisher exact test P < .05.