HRs and 95% CIs from multivariable competing risk regression models for SMs among 4023 patients with MPN
| . | Model 1 (HU Yes/No) . | Model 2 (HU PDC) . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Hydroxyurea | ||||
| No | 1.00 | — | — | — |
| Yes | 0.99 (0.82-1.20) | .92 | — | — |
| PDC (per 10%) | — | — | 1.01 (0.99-1.03) | .43 |
| Type of MPN | ||||
| PV | 1.00 | — | 1.00 | — |
| ET | 1.15 (0.94-1.39) | .17 | 1.13 (0.93-1.37) | .22 |
| MF | 1.22 (0.88-1.68) | .23 | 1.24 (0.90-1.71) | .19 |
| Age, y | ||||
| 66-69 | 1.00 | — | 1.00 | — |
| 70-74 | 0.99 (0.76-1.30) | .95 | 0.99 (0.76-1.30) | .95 |
| 75-79 | 0.92 (0.70-1.21) | .56 | 0.91 (0.69-1.21) | .53 |
| 80-84 | 0.76 (0.57-1.03) | .07 | 0.76 (0.56-1.02) | .07 |
| ≥85 | 0.63 (0.46-0.86) | <.01 | 0.63 (0.45-0.86) | <.01 |
| Sex | ||||
| Female | 1.00 | — | 1.00 | — |
| Male | 1.23 (1.01-1.48) | .04 | 1.23 (1.02-1.49) | .03 |
| Race | ||||
| White | 1.00 | — | 1.00 | — |
| Other | 0.76 (0.56-1.03) | .08 | 0.76 (0.56-1.03) | .08 |
| Marital status | ||||
| Single | 1.00 | — | 1.00 | — |
| Married | 0.94 (0.76-1.17) | .60 | 0.95 (0.76-1.18) | .63 |
| Unknown | 1.20 (0.86-1.66) | .28 | 1.20 (0.86-1.66) | .28 |
| Region | ||||
| Northeast | 1.00 | — | 1.00 | — |
| Midwest | 1.13 (0.81-1.56) | .48 | 1.12 (0.80-1.55) | .51 |
| South | 1.03 (0.77-1.38) | .85 | 1.03 (0.77-1.38) | .84 |
| West | 1.06 (0.84-1.34) | .61 | 1.06 (0.84-1.34) | .64 |
| Elixhauser Comorbidity Index | ||||
| 0 | 1.00 | — | 1.00 | — |
| 1-2 | 1.05 (0.79-1.41) | .74 | 1.05 (0.79-1.41) | .73 |
| ≥3 | 1.12 (0.84-1.50) | .43 | 1.13 (0.84-1.51) | .41 |
| Previous cancer | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 1.20 (0.98-1.47) | .08 | 1.20 (0.98-1.47) | .08 |
| Disability | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 0.57 (0.39-0.83) | <.01 | 0.57 (0.39-0.84) | <.01 |
| Census tract Yost index | ||||
| Fifth quintile (highest SES) | 1.00 | — | 1.00 | — |
| Fourth quintile | 0.79 (0.61-1.02) | .08 | 0.79 (0.61-1.02) | .08 |
| Third quintile | 0.81 (0.61-1.08) | .15 | 0.81 (0.61-1.08) | .15 |
| Second quintile | 0.91 (0.69-1.20) | .51 | 0.91 (0.69-1.20) | .50 |
| First quintile (lowest SES) | 0.88 (0.61-1.26) | .48 | 0.88 (0.61-1.27) | .49 |
| Unknown | 1.06 (0.68-1.66) | .79 | 1.06 (0.68-1.65) | .81 |
| State buy-in | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 0.96 (0.72-1.27) | .77 | 0.96 (0.72-1.28) | .78 |
| . | Model 1 (HU Yes/No) . | Model 2 (HU PDC) . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Hydroxyurea | ||||
| No | 1.00 | — | — | — |
| Yes | 0.99 (0.82-1.20) | .92 | — | — |
| PDC (per 10%) | — | — | 1.01 (0.99-1.03) | .43 |
| Type of MPN | ||||
| PV | 1.00 | — | 1.00 | — |
| ET | 1.15 (0.94-1.39) | .17 | 1.13 (0.93-1.37) | .22 |
| MF | 1.22 (0.88-1.68) | .23 | 1.24 (0.90-1.71) | .19 |
| Age, y | ||||
| 66-69 | 1.00 | — | 1.00 | — |
| 70-74 | 0.99 (0.76-1.30) | .95 | 0.99 (0.76-1.30) | .95 |
| 75-79 | 0.92 (0.70-1.21) | .56 | 0.91 (0.69-1.21) | .53 |
| 80-84 | 0.76 (0.57-1.03) | .07 | 0.76 (0.56-1.02) | .07 |
| ≥85 | 0.63 (0.46-0.86) | <.01 | 0.63 (0.45-0.86) | <.01 |
| Sex | ||||
| Female | 1.00 | — | 1.00 | — |
| Male | 1.23 (1.01-1.48) | .04 | 1.23 (1.02-1.49) | .03 |
| Race | ||||
| White | 1.00 | — | 1.00 | — |
| Other | 0.76 (0.56-1.03) | .08 | 0.76 (0.56-1.03) | .08 |
| Marital status | ||||
| Single | 1.00 | — | 1.00 | — |
| Married | 0.94 (0.76-1.17) | .60 | 0.95 (0.76-1.18) | .63 |
| Unknown | 1.20 (0.86-1.66) | .28 | 1.20 (0.86-1.66) | .28 |
| Region | ||||
| Northeast | 1.00 | — | 1.00 | — |
| Midwest | 1.13 (0.81-1.56) | .48 | 1.12 (0.80-1.55) | .51 |
| South | 1.03 (0.77-1.38) | .85 | 1.03 (0.77-1.38) | .84 |
| West | 1.06 (0.84-1.34) | .61 | 1.06 (0.84-1.34) | .64 |
| Elixhauser Comorbidity Index | ||||
| 0 | 1.00 | — | 1.00 | — |
| 1-2 | 1.05 (0.79-1.41) | .74 | 1.05 (0.79-1.41) | .73 |
| ≥3 | 1.12 (0.84-1.50) | .43 | 1.13 (0.84-1.51) | .41 |
| Previous cancer | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 1.20 (0.98-1.47) | .08 | 1.20 (0.98-1.47) | .08 |
| Disability | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 0.57 (0.39-0.83) | <.01 | 0.57 (0.39-0.84) | <.01 |
| Census tract Yost index | ||||
| Fifth quintile (highest SES) | 1.00 | — | 1.00 | — |
| Fourth quintile | 0.79 (0.61-1.02) | .08 | 0.79 (0.61-1.02) | .08 |
| Third quintile | 0.81 (0.61-1.08) | .15 | 0.81 (0.61-1.08) | .15 |
| Second quintile | 0.91 (0.69-1.20) | .51 | 0.91 (0.69-1.20) | .50 |
| First quintile (lowest SES) | 0.88 (0.61-1.26) | .48 | 0.88 (0.61-1.27) | .49 |
| Unknown | 1.06 (0.68-1.66) | .79 | 1.06 (0.68-1.65) | .81 |
| State buy-in | ||||
| No | 1.00 | — | 1.00 | — |
| Yes | 0.96 (0.72-1.27) | .77 | 0.96 (0.72-1.28) | .78 |
All variables in the table were mutually adjusted in the model.
PDC, proportion of drug coverage.