Effect of prolonged combination treatment of healthy baboons
| Animal . | HbF group . | F-cells . | HbF . | HbF/F-cell . | ||
|---|---|---|---|---|---|---|
| Before . | After . | Before . | After . | After . | ||
| PA 9254 | Low | 3.5 | 42.5 | 0.008 | 0.10 | 23.5 |
| PA 9194 | High | 10.7 | 60.5 | 0.02 | 0.20 | 33.0 |
| Animal . | HbF group . | F-cells . | HbF . | HbF/F-cell . | ||
|---|---|---|---|---|---|---|
| Before . | After . | Before . | After . | After . | ||
| PA 9254 | Low | 3.5 | 42.5 | 0.008 | 0.10 | 23.5 |
| PA 9194 | High | 10.7 | 60.5 | 0.02 | 0.20 | 33.0 |
| . | ANC (per μL) . | Platelets (× 103/μL) . | |||||
|---|---|---|---|---|---|---|---|
| Before . | Nadir . | Mean . | Before . | Nadir . | Max . | Mean . | |
| PA 9254 | 2170 | 1460 | 2780 + 1250 | 409 | 256 | 616 | 353 + 81 |
| PA 9194 | 3880 | 1400 | 3245 + 1604 | 274 | 198 | 403 | 257 + 44 |
| . | ANC (per μL) . | Platelets (× 103/μL) . | |||||
|---|---|---|---|---|---|---|---|
| Before . | Nadir . | Mean . | Before . | Nadir . | Max . | Mean . | |
| PA 9254 | 2170 | 1460 | 2780 + 1250 | 409 | 256 | 616 | 353 + 81 |
| PA 9194 | 3880 | 1400 | 3245 + 1604 | 274 | 198 | 403 | 257 + 44 |
ANC, absolute neutrophil count; Max, maximum.