Table 1. Effect of RN-1 and Decaitabine,... | American Society of Hematology

Table 1.

Effect of RN-1 and Decaitabine, alone and in combination, on F-retics and γ-globin mRNA in low- and high-HbF group baboons

HbF group	Animal	Drug	F-retics	γ-globin mRNA (γ/γ + β)	Animal	Drug	F-retics	γ-globin mRNA (γ/γ + β)	Animal	Drug	F-retics	γ-globin mRNA (γ/γ + β)
Low	9197	RN1	13.8	0.07	9197	DAC	6.3	0.022	9197	Comb	38.3	0.13
	9197	RN1	16.2	0.072	9197	DAC	7.9	0.023	9197	Comb	43.6	0.16
	9254	RN1	11.9	0.097	9254	DAC	6.3	0.053	9254	Comb	53.7	0.23
	9254	RN1	21.3	0.082	9254	DAC	3.3	0.039	9254	Comb	54.3	0.26
Mean			15.6	0.080			5.95	0.034			47.5	0.19
SD			4.25	0.012			1.92	0.014			7.84	0.06
High	9194	RN1	25.8	0.076	9194	DAC	27.9	0.14	9194	Comb	61.5	0.289
	9194	RN1	32.5	0.146	9194	DAC	28.4	0.09	9194	Comb	61.8	0.275
	9194	RN1	37.5	0.181	9255	DAC	29.1	0.127	9255	Comb	71.8	0.304
	9255	RN1	29.8	0.171	9255	DAC	15.4	0.093	9255	Comb	66.5	0.268
Mean			31.4	0.144			25.2	0.113			65.4	0.284
SD			4.91	0.047			6.55	0.025			4.82	0.016

HbF group	Animal	Drug	F-retics	γ-globin mRNA (γ/γ + β)	Animal	Drug	F-retics	γ-globin mRNA (γ/γ + β)	Animal	Drug	F-retics	γ-globin mRNA (γ/γ + β)
Low	9197	RN1	13.8	0.07	9197	DAC	6.3	0.022	9197	Comb	38.3	0.13
	9197	RN1	16.2	0.072	9197	DAC	7.9	0.023	9197	Comb	43.6	0.16
	9254	RN1	11.9	0.097	9254	DAC	6.3	0.053	9254	Comb	53.7	0.23
	9254	RN1	21.3	0.082	9254	DAC	3.3	0.039	9254	Comb	54.3	0.26
Mean			15.6	0.080			5.95	0.034			47.5	0.19
SD			4.25	0.012			1.92	0.014			7.84	0.06
High	9194	RN1	25.8	0.076	9194	DAC	27.9	0.14	9194	Comb	61.5	0.289
	9194	RN1	32.5	0.146	9194	DAC	28.4	0.09	9194	Comb	61.8	0.275
	9194	RN1	37.5	0.181	9255	DAC	29.1	0.127	9255	Comb	71.8	0.304
	9255	RN1	29.8	0.171	9255	DAC	15.4	0.093	9255	Comb	66.5	0.268
Mean			31.4	0.144			25.2	0.113			65.4	0.284
SD			4.91	0.047			6.55	0.025			4.82	0.016

Comb, DAC/RN-1 combination; DAC, decitabine; SD, standard deviation.