Multivariate Cox model of OS in pretransplant subgroups of patients who tested as MRD+ and MRD-negative
| Pretransplant MRD status . | Variable . | Reference level . | HR (95% CI) . | P . |
|---|---|---|---|---|
| MRD+ | FLT3 status: present | Absent | 1.32 (0.87-2.00) | .19 |
| Cytogenetic risk group: adverse | Favorable/intermediate risk | 1.38 (0.91-2.09) | .13 | |
| Posttransplant MRD status (time-dependent): positive | Negative | 2.70 (1.76-4.15) | < .001 | |
| Chronic GVHD (time-dependent): yes | No | 0.92 (0.53-1.62) | .78 | |
| MRD-negative | FLT3 status: present | Absent | 1.31 (0.88-1.97) | .18 |
| Cytogenetic risk group: adverse | Favorable/intermediate risk | 1.61 (1.08-2.39) | .019 | |
| Posttransplant MRD status (time-dependent): positive | Negative | 2.68 (1.79-4.03) | < .001 | |
| Chronic GVHD (time-dependent): Yes | No | 0.92 (0.54-1.57) | .77 |
| Pretransplant MRD status . | Variable . | Reference level . | HR (95% CI) . | P . |
|---|---|---|---|---|
| MRD+ | FLT3 status: present | Absent | 1.32 (0.87-2.00) | .19 |
| Cytogenetic risk group: adverse | Favorable/intermediate risk | 1.38 (0.91-2.09) | .13 | |
| Posttransplant MRD status (time-dependent): positive | Negative | 2.70 (1.76-4.15) | < .001 | |
| Chronic GVHD (time-dependent): yes | No | 0.92 (0.53-1.62) | .78 | |
| MRD-negative | FLT3 status: present | Absent | 1.31 (0.88-1.97) | .18 |
| Cytogenetic risk group: adverse | Favorable/intermediate risk | 1.61 (1.08-2.39) | .019 | |
| Posttransplant MRD status (time-dependent): positive | Negative | 2.68 (1.79-4.03) | < .001 | |
| Chronic GVHD (time-dependent): Yes | No | 0.92 (0.54-1.57) | .77 |
MRD status and chronic GVHD analyzed as time-dependent variables.