Summary of baseline HRQoL scores by disease group
| QOL measure . | Statistic . | MDS (N = 248) . | MDS/MPN (N = 40) . | ICUS (N = 48) . | AML<30% (N = 15) . | At-risk (N = 98) . |
|---|---|---|---|---|---|---|
| QUALMS mean score | Mean (95% CI) | 69.7 (68.0-71.4) | 71.7 (67.3-76.1) | 73.5 (69.5-77.4) | 65.7 (58.5-72.9) | 73.2 (70.4-76.0) |
| P value (vs MDS) | - | .923 | .606 | .923 | .349 | |
| QUALMS physical burden | Mean (95% CI) | 67.1 (64.9-69.3) | 69.6 (64.0-75.2) | 69.0 (64.0-74.1) | 67.4 (58.1-76.7) | 72.0 (68.4-75.6) |
| P value (vs MDS) | - | .944 | .944 | .944 | .223 | |
| QUALMS benefit finding | Mean (95% CI) | 59.1 (55.9-62.3) | 56.5 (48.6-64.5) | 59.0 (51.8-66.3) | 55.4 (42.2-68.5) | 54.0 (49.0-59.1) |
| P value (vs MDS) | - | .987 | .987 | .987 | .963 | |
| QUALMS emotional | Mean (95% CI) | 71.0 (68.7-73.3) | 72.9 (67.0-78.9) | 78.0 (72.6-83.4) | 63.6 (53.8-73.4) | 75.3 (71.5-79.1) |
| P value (vs MDS) | - | .549 | .172 | .549 | .407 | |
| FACT-G total score | Mean (95% CI) | 81.1 (79.1-83.2) | 82.0 (76.9-87.1) | 84.6 (79.9-89.3) | 82.6 (74.5-90.7) | 82.4 (79.2-85.7) |
| P value (vs MDS) | - | .964 | .964 | .964 | .964 | |
| FACT-G physical well-being | Mean (95% CI) | 22.4 (21.8-23.0) | 22.8 (21.3-24.3) | 22.7 (21.4-24.1) | 22.4 (20.0-24.9) | 23.2 (22.2-24.2) |
| P value (vs MDS) | - | .985 | .985 | .985 | .985 | |
| FACT-G social well-being | Mean (95% CI) | 22.5 (21.8-23.2) | 22.4 (20.6-24.3) | 22.4 (20.7-24.0) | 23.6 (20.6-26.5) | 21.8 (20.7-23.0) |
| P value (vs MDS) | - | .955 | .955 | .955 | .955 | |
| FACT-G emotional well-being | Mean (95% CI) | 18.1 (17.6-18.7) | 17.5 (16.2-18.9) | 18.7 (17.4-19.9) | 17.5 (15.3-19.7) | 18.4 (17.5-19.3) |
| P value (vs MDS) | - | .984 | .984 | .984 | .984 | |
| FACT-G functional well-being | Mean (95% CI) | 18.3 (17.5-19.1) | 18.9 (16.9-21.0) | 20.2 (18.4-22.1) | 19.1 (15.8-22.3) | 19.5 (18.2-20.8) |
| P value (vs MDS) | - | .949 | .629 | .949 | .949 | |
| EQ-5D-5L total score | Mean (95% CI) | 70.3 (67.8-72.7) | 74.3 (68.3-80.4) | 74.3 (68.7-79.9) | 64.3 (54.5-74.1) | 73.4 (69.5-77.3) |
| P value (vs MDS) | - | .996 | .996 | .996 | .996 | |
| PROMIS Fatigue mean T-score | Mean (95% CI) | 51.7 (50.7-52.7) | 50.0 (47.4-52.5) | 51.8 (49.5-54.1) | 50.0 (45.9-54.1) | 51.1 (49.5-52.7) |
| P value (vs MDS) | - | .973 | .973 | .973 | .973 |
| QOL measure . | Statistic . | MDS (N = 248) . | MDS/MPN (N = 40) . | ICUS (N = 48) . | AML<30% (N = 15) . | At-risk (N = 98) . |
|---|---|---|---|---|---|---|
| QUALMS mean score | Mean (95% CI) | 69.7 (68.0-71.4) | 71.7 (67.3-76.1) | 73.5 (69.5-77.4) | 65.7 (58.5-72.9) | 73.2 (70.4-76.0) |
| P value (vs MDS) | - | .923 | .606 | .923 | .349 | |
| QUALMS physical burden | Mean (95% CI) | 67.1 (64.9-69.3) | 69.6 (64.0-75.2) | 69.0 (64.0-74.1) | 67.4 (58.1-76.7) | 72.0 (68.4-75.6) |
| P value (vs MDS) | - | .944 | .944 | .944 | .223 | |
| QUALMS benefit finding | Mean (95% CI) | 59.1 (55.9-62.3) | 56.5 (48.6-64.5) | 59.0 (51.8-66.3) | 55.4 (42.2-68.5) | 54.0 (49.0-59.1) |
| P value (vs MDS) | - | .987 | .987 | .987 | .963 | |
| QUALMS emotional | Mean (95% CI) | 71.0 (68.7-73.3) | 72.9 (67.0-78.9) | 78.0 (72.6-83.4) | 63.6 (53.8-73.4) | 75.3 (71.5-79.1) |
| P value (vs MDS) | - | .549 | .172 | .549 | .407 | |
| FACT-G total score | Mean (95% CI) | 81.1 (79.1-83.2) | 82.0 (76.9-87.1) | 84.6 (79.9-89.3) | 82.6 (74.5-90.7) | 82.4 (79.2-85.7) |
| P value (vs MDS) | - | .964 | .964 | .964 | .964 | |
| FACT-G physical well-being | Mean (95% CI) | 22.4 (21.8-23.0) | 22.8 (21.3-24.3) | 22.7 (21.4-24.1) | 22.4 (20.0-24.9) | 23.2 (22.2-24.2) |
| P value (vs MDS) | - | .985 | .985 | .985 | .985 | |
| FACT-G social well-being | Mean (95% CI) | 22.5 (21.8-23.2) | 22.4 (20.6-24.3) | 22.4 (20.7-24.0) | 23.6 (20.6-26.5) | 21.8 (20.7-23.0) |
| P value (vs MDS) | - | .955 | .955 | .955 | .955 | |
| FACT-G emotional well-being | Mean (95% CI) | 18.1 (17.6-18.7) | 17.5 (16.2-18.9) | 18.7 (17.4-19.9) | 17.5 (15.3-19.7) | 18.4 (17.5-19.3) |
| P value (vs MDS) | - | .984 | .984 | .984 | .984 | |
| FACT-G functional well-being | Mean (95% CI) | 18.3 (17.5-19.1) | 18.9 (16.9-21.0) | 20.2 (18.4-22.1) | 19.1 (15.8-22.3) | 19.5 (18.2-20.8) |
| P value (vs MDS) | - | .949 | .629 | .949 | .949 | |
| EQ-5D-5L total score | Mean (95% CI) | 70.3 (67.8-72.7) | 74.3 (68.3-80.4) | 74.3 (68.7-79.9) | 64.3 (54.5-74.1) | 73.4 (69.5-77.3) |
| P value (vs MDS) | - | .996 | .996 | .996 | .996 | |
| PROMIS Fatigue mean T-score | Mean (95% CI) | 51.7 (50.7-52.7) | 50.0 (47.4-52.5) | 51.8 (49.5-54.1) | 50.0 (45.9-54.1) | 51.1 (49.5-52.7) |
| P value (vs MDS) | - | .973 | .973 | .973 | .973 |
Estimates based on ANCOVA model adjusted for age. P values for pairwise comparisons adjusted using the Hochberg procedure. P values for overall F test for comparison of scores between diagnostic categories: QUALMS mean (P = .082), physical burden (P = .242), benefit finding (P = .539), emotional (P = .028), FACT-G total (P = .750), physical well-being (P = .748), social well-being (P = .818), emotional well-being (P = .700), functional well-being (P = .293), EQ-5D-5L (P = .214), PROMIS Fatigue (P = .681).
ANCOVA, analysis of covariance; N, number of participants in each disease group with an observed QOL score and vulnerability data.