Summary of baseline characteristics by disease subgroup
| Characteristic . | Statistic . | MDS (N = 248) . | MDS/MPN (N = 40) . | ICUS (N = 48) . | AML<30% (N = 15) . | At-risk (N = 98) . | All (N = 449) . | P value . |
|---|---|---|---|---|---|---|---|---|
| Age | Mean ± SD | 71.8 ± 10.1 | 76.5 ± 7.4 | 69.9 ± 12.4 | 73.1 ± 7.8 | 71.9 ± 10.6 | 72.1 ± 10.2 | .039 |
| Sex | Female, n (%) | 86 (35%) | 6 (15%) | 17 (35%) | 4 (27%) | 31 (32%) | 144 (32%) | .139 |
| Male, n (%) | 162 (65%) | 34 (85%) | 31 (65%) | 11 (73%) | 67 (68%) | 305 (68%) | ||
| Race | American Indian/Alaska Native, n (%) | 2 (1%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (0%) | .002 |
| Asian, n (%) | 1 (0%) | 0 (0%) | 2 (4%) | 1 (7%) | 4 (4%) | 8 (2%) | ||
| Black, n (%) | 5 (2%) | 2 (5%) | 5 (10%) | 1 (7%) | 1 (1%) | 14 (3%) | ||
| Native Hawaiian/Pacific Islander, n (%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | ||
| White, n (%) | 235 (95%) | 38 (95%) | 37 (77%) | 13 (87%) | 93 (95%) | 416 (93%) | ||
| More than 1 race, n (%) | 0 (0%) | 0 (0%) | 1 (2%) | 0 (0%) | 0 (0%) | 1 (0%) | ||
| Unknown/not reported, n (%) | 5 (2%) | 0 (0%) | 3 (6%) | 0 (0%) | 0 (0%) | 8 (2%) | ||
| Ethnicity | Hispanic or Latino, n (%) | 4 (2%) | 2 (5%) | 4 (8%) | 1 (7%) | 1 (1%) | 12 (3%) | .069 |
| Not Hispanic or Latino, n (%) | 237 (96%) | 38 (95%) | 44 (92%) | 13 (87%) | 95 (97%) | 427 (95%) | ||
| Unknown/not reported, n (%) | 7 (3%) | 0 (0%) | 0 (0%) | 1 (7%) | 2 (2%) | 10 (2%) | ||
| BMI | Mean ± SD | 29.1 ± 6.3 | 27.4 ± 5.7 | 27.8 ± 4.7 | 30.4 ± 3.2 | 28.9 ± 5.7 | 28.8 ± 5.9 | .257 |
| Blast % | Mean ± SD | 4.1 ± 4.7 | 3.6 ± 4.5 | 1.5 ± 4.3 | 22.2 ± 2.5 | 1.0 ± 1.1 | 3.8 ± 6.3 | <.001 |
| Hemoglobin (g/dL) | <8, n (%) | 42 (17%) | 5 (13%) | 1 (2%) | 1 (7%) | 7 (7%) | 56 (12%) | <.001 |
| 8-10, n (%) | 90 (36%) | 12 (30%) | 10 (21%) | 8 (53%) | 13 (13%) | 133 (30%) | ||
| >10, n (%) | 116 (47%) | 23 (58%) | 37 (77%) | 6 (40%) | 78 (80%) | 260 (58%) | ||
| Platelets (10⁹/L) | <50, n(%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | - |
| ≥50, n (%) | 248 (100%) | 40 (100%) | 48 (100%) | 15 (100%) | 98 (100%) | 449 (100%) | ||
| Absolute Neutrophil Count (106/L) | <800, n (%) | 44 (18%) | 4 (10%) | 1 (2%) | 12 (80%) | 4 (4%) | 65 (14%) | <.001 |
| ≥800, n (%) | 198 (80%) | 35 (88%) | 45 (94%) | 3 (20%) | 91 (93%) | 372 (83%) | ||
| Missing, n (%) | 6 (2%) | 1 (3%) | 2 (4%) | 0 (0%) | 3 (3%) | 12 (3%) | ||
| Vulnerable∗ | Vulnerable, n (%) | 84 (34%) | 18 (45%) | 12 (25%) | 5 (33%) | 30 (31%) | 149 (33%) | .370 |
| IPSS-R | Very low, n (%) | 56 (23%) | 5 (13%) | — | — | — | — | — |
| Low, n (%) | 72 (29%) | 16 (40%) | — | — | — | — | ||
| Intermediate, n (%) | 46 (19%) | 8 (20%) | — | — | — | — | ||
| High, n (%) | 28 (11%) | 1 (3%) | — | — | — | — | ||
| Very high, n (%) | 29 (12%) | 0 (0%) | — | — | — | — | ||
| Not calculated, n (%) | 17 (7%) | 10 (25%) | — | — | — | — |
| Characteristic . | Statistic . | MDS (N = 248) . | MDS/MPN (N = 40) . | ICUS (N = 48) . | AML<30% (N = 15) . | At-risk (N = 98) . | All (N = 449) . | P value . |
|---|---|---|---|---|---|---|---|---|
| Age | Mean ± SD | 71.8 ± 10.1 | 76.5 ± 7.4 | 69.9 ± 12.4 | 73.1 ± 7.8 | 71.9 ± 10.6 | 72.1 ± 10.2 | .039 |
| Sex | Female, n (%) | 86 (35%) | 6 (15%) | 17 (35%) | 4 (27%) | 31 (32%) | 144 (32%) | .139 |
| Male, n (%) | 162 (65%) | 34 (85%) | 31 (65%) | 11 (73%) | 67 (68%) | 305 (68%) | ||
| Race | American Indian/Alaska Native, n (%) | 2 (1%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (0%) | .002 |
| Asian, n (%) | 1 (0%) | 0 (0%) | 2 (4%) | 1 (7%) | 4 (4%) | 8 (2%) | ||
| Black, n (%) | 5 (2%) | 2 (5%) | 5 (10%) | 1 (7%) | 1 (1%) | 14 (3%) | ||
| Native Hawaiian/Pacific Islander, n (%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | ||
| White, n (%) | 235 (95%) | 38 (95%) | 37 (77%) | 13 (87%) | 93 (95%) | 416 (93%) | ||
| More than 1 race, n (%) | 0 (0%) | 0 (0%) | 1 (2%) | 0 (0%) | 0 (0%) | 1 (0%) | ||
| Unknown/not reported, n (%) | 5 (2%) | 0 (0%) | 3 (6%) | 0 (0%) | 0 (0%) | 8 (2%) | ||
| Ethnicity | Hispanic or Latino, n (%) | 4 (2%) | 2 (5%) | 4 (8%) | 1 (7%) | 1 (1%) | 12 (3%) | .069 |
| Not Hispanic or Latino, n (%) | 237 (96%) | 38 (95%) | 44 (92%) | 13 (87%) | 95 (97%) | 427 (95%) | ||
| Unknown/not reported, n (%) | 7 (3%) | 0 (0%) | 0 (0%) | 1 (7%) | 2 (2%) | 10 (2%) | ||
| BMI | Mean ± SD | 29.1 ± 6.3 | 27.4 ± 5.7 | 27.8 ± 4.7 | 30.4 ± 3.2 | 28.9 ± 5.7 | 28.8 ± 5.9 | .257 |
| Blast % | Mean ± SD | 4.1 ± 4.7 | 3.6 ± 4.5 | 1.5 ± 4.3 | 22.2 ± 2.5 | 1.0 ± 1.1 | 3.8 ± 6.3 | <.001 |
| Hemoglobin (g/dL) | <8, n (%) | 42 (17%) | 5 (13%) | 1 (2%) | 1 (7%) | 7 (7%) | 56 (12%) | <.001 |
| 8-10, n (%) | 90 (36%) | 12 (30%) | 10 (21%) | 8 (53%) | 13 (13%) | 133 (30%) | ||
| >10, n (%) | 116 (47%) | 23 (58%) | 37 (77%) | 6 (40%) | 78 (80%) | 260 (58%) | ||
| Platelets (10⁹/L) | <50, n(%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | - |
| ≥50, n (%) | 248 (100%) | 40 (100%) | 48 (100%) | 15 (100%) | 98 (100%) | 449 (100%) | ||
| Absolute Neutrophil Count (106/L) | <800, n (%) | 44 (18%) | 4 (10%) | 1 (2%) | 12 (80%) | 4 (4%) | 65 (14%) | <.001 |
| ≥800, n (%) | 198 (80%) | 35 (88%) | 45 (94%) | 3 (20%) | 91 (93%) | 372 (83%) | ||
| Missing, n (%) | 6 (2%) | 1 (3%) | 2 (4%) | 0 (0%) | 3 (3%) | 12 (3%) | ||
| Vulnerable∗ | Vulnerable, n (%) | 84 (34%) | 18 (45%) | 12 (25%) | 5 (33%) | 30 (31%) | 149 (33%) | .370 |
| IPSS-R | Very low, n (%) | 56 (23%) | 5 (13%) | — | — | — | — | — |
| Low, n (%) | 72 (29%) | 16 (40%) | — | — | — | — | ||
| Intermediate, n (%) | 46 (19%) | 8 (20%) | — | — | — | — | ||
| High, n (%) | 28 (11%) | 1 (3%) | — | — | — | — | ||
| Very high, n (%) | 29 (12%) | 0 (0%) | — | — | — | — | ||
| Not calculated, n (%) | 17 (7%) | 10 (25%) | — | — | — | — |
Fisher exact test used for comparing proportions of demographic factors between disease groups. An ANOVA used for comparing means of demographic factors between disease groups.
ANOVA, analysis of variance; BMI, body mass index; N, number of participants in each disease category.
Vulnerable participants are those with VES-13 ≥3.