Ineligibility criteria by race and ethnicity
| Reasons for ineligibility∗ . | Total N = 1614 n (%) . | Race . | Ethnicity . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| White N = 1338 n (%) . | Black N = 88 n (%) . | Asian N = 73 n (%) . | Other∗ N = 40 n (%) . | Unknown N = 75 n (%) . | Hispanic or Latino N = 70 n (%) . | Not Hispanic or Latino N = 1088 n (%) . | Unknown N = 456 n (%) . | ||
| Disease related | 431 (27) | 368 (28) | 16 (18) | 21 (29) | 9 (22) | 17 (23) | 15 (21) | 291 (27) | 125 (27) |
| Failure to meet treatment related criteria | 195 (12) | 167 (12) | 15 (17) | 4 (5) | 3 (8) | 6 (8) | 7 (10) | 136 (12) | 52 (11) |
| Received restricted investigational drugs or chemotherapy within time period | 75 (5) | 63 (5) | 5 (6) | 2 (3) | 1 (2) | 4 (5) | 6 (9) | 40 (4) | 29 (6) |
| Hepatic function | 12 (1) | 10 (1) | NA | 1 (1) | 1 (2) | NA | NA | 6 (1) | 6 (1) |
| Renal function | 52 (3) | 44 (3) | 4 (5) | 1 (1) | 1 (2) | 2 (3) | NA | 39 (4) | 13 (3) |
| Cardiac function | 73 (5) | 63 (5) | 3 (3) | 4 (5) | 1 (2) | 2 (3) | 3 (4) | 42 (4) | 28 (6) |
| Pulmonary function | 37 (2) | 33 (2) | NA | 2 (3) | NA | 2 (3) | 4 (6) | 31 (3) | 2 (<1) |
| Hematology laboratory criteria | 171 (11) | 132 (10) | 17 (19) | 8 (11) | 6 (15) | 8 (11) | 2 (3) | 76 (7) | 93 (20) |
| Unspecified laboratory criteria† | 248 (15) | 197 (15) | 8 (9) | 14 (19) | 5 (12) | 24 (32) | 10 (14) | 162 (15) | 76 (17) |
| Active infection | 25 (2) | 21 (2) | 1 (1) | NA | 3 (8) | NA | NA | 15 (1) | 10 (2) |
| HIV or hepatitis virus | 31 (2) | 27 (2) | 3 (3) | 1 (1) | NA | NA | 1 (1) | 20 (2) | 10 (2) |
| Preexisting neuropathy | 7 (<1) | 6 (0) | 1 (1) | NA | NA | NA | NA | 5 (0) | 2 (<1) |
| Prior malignancy | 31 (2) | 26 (2) | 1 (1) | 2 (3) | 2 (5) | NA | 1 (1) | 22 (2) | 8 (2) |
| Contraception related | 67 (4) | 58 (4) | 3 (3) | 4 (5) | 1 (2) | 1 (1) | NA | 5 (0) | 62 (14) |
| Other IE exclusions | 274 (17) | 228 (17) | 18 (20) | 12 (16) | 12 (30) | 4 (5) | 8 (11) | 109 (10) | 157 (34) |
| Patient decision | 81 (5) | 69 (5) | 6 (7) | 3 (4) | 1 (2) | 2 (3) | 6 (9) | 68 (6) | 7 (2) |
| Missing | 84 (5) | 63 (5) | 3 (3) | 10 (14) | 2 (5) | 6 (8) | 9 (13) | 62 (6) | 13 (3) |
| Reasons for ineligibility∗ . | Total N = 1614 n (%) . | Race . | Ethnicity . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| White N = 1338 n (%) . | Black N = 88 n (%) . | Asian N = 73 n (%) . | Other∗ N = 40 n (%) . | Unknown N = 75 n (%) . | Hispanic or Latino N = 70 n (%) . | Not Hispanic or Latino N = 1088 n (%) . | Unknown N = 456 n (%) . | ||
| Disease related | 431 (27) | 368 (28) | 16 (18) | 21 (29) | 9 (22) | 17 (23) | 15 (21) | 291 (27) | 125 (27) |
| Failure to meet treatment related criteria | 195 (12) | 167 (12) | 15 (17) | 4 (5) | 3 (8) | 6 (8) | 7 (10) | 136 (12) | 52 (11) |
| Received restricted investigational drugs or chemotherapy within time period | 75 (5) | 63 (5) | 5 (6) | 2 (3) | 1 (2) | 4 (5) | 6 (9) | 40 (4) | 29 (6) |
| Hepatic function | 12 (1) | 10 (1) | NA | 1 (1) | 1 (2) | NA | NA | 6 (1) | 6 (1) |
| Renal function | 52 (3) | 44 (3) | 4 (5) | 1 (1) | 1 (2) | 2 (3) | NA | 39 (4) | 13 (3) |
| Cardiac function | 73 (5) | 63 (5) | 3 (3) | 4 (5) | 1 (2) | 2 (3) | 3 (4) | 42 (4) | 28 (6) |
| Pulmonary function | 37 (2) | 33 (2) | NA | 2 (3) | NA | 2 (3) | 4 (6) | 31 (3) | 2 (<1) |
| Hematology laboratory criteria | 171 (11) | 132 (10) | 17 (19) | 8 (11) | 6 (15) | 8 (11) | 2 (3) | 76 (7) | 93 (20) |
| Unspecified laboratory criteria† | 248 (15) | 197 (15) | 8 (9) | 14 (19) | 5 (12) | 24 (32) | 10 (14) | 162 (15) | 76 (17) |
| Active infection | 25 (2) | 21 (2) | 1 (1) | NA | 3 (8) | NA | NA | 15 (1) | 10 (2) |
| HIV or hepatitis virus | 31 (2) | 27 (2) | 3 (3) | 1 (1) | NA | NA | 1 (1) | 20 (2) | 10 (2) |
| Preexisting neuropathy | 7 (<1) | 6 (0) | 1 (1) | NA | NA | NA | NA | 5 (0) | 2 (<1) |
| Prior malignancy | 31 (2) | 26 (2) | 1 (1) | 2 (3) | 2 (5) | NA | 1 (1) | 22 (2) | 8 (2) |
| Contraception related | 67 (4) | 58 (4) | 3 (3) | 4 (5) | 1 (2) | 1 (1) | NA | 5 (0) | 62 (14) |
| Other IE exclusions | 274 (17) | 228 (17) | 18 (20) | 12 (16) | 12 (30) | 4 (5) | 8 (11) | 109 (10) | 157 (34) |
| Patient decision | 81 (5) | 69 (5) | 6 (7) | 3 (4) | 1 (2) | 2 (3) | 6 (9) | 68 (6) | 7 (2) |
| Missing | 84 (5) | 63 (5) | 3 (3) | 10 (14) | 2 (5) | 6 (8) | 9 (13) | 62 (6) | 13 (3) |