Patients with treatment-emergent hepatic AESI (greater than 1%) of all grades, and of grade 3 or 4 severity
| Patients with hepatic AESI (>1%) . | All grades, n (%) . | Grade 3 or 4, n (%) . |
|---|---|---|
| Patients with at least 1 treatment-emergent hepatic AESI | 38 (25) | 23 (15) |
| Investigations | 33 (22) | 19 (12) |
| Alanine aminotransferase increased | 18 (12) | 7 (5) |
| Aspartate aminotransferase increased | 14 (9) | 4 (3) |
| Gamma-glutamyltransferase increased | 10 (7) | 8 (5) |
| Blood bilirubin increased | 8 (5) | 2 (1) |
| Hepatic enzyme increased | 7 (5) | 5 (3) |
| Liver function test deviated | 3 (2) | 3 (2) |
| Patients with hepatic AESI (>1%) . | All grades, n (%) . | Grade 3 or 4, n (%) . |
|---|---|---|
| Patients with at least 1 treatment-emergent hepatic AESI | 38 (25) | 23 (15) |
| Investigations | 33 (22) | 19 (12) |
| Alanine aminotransferase increased | 18 (12) | 7 (5) |
| Aspartate aminotransferase increased | 14 (9) | 4 (3) |
| Gamma-glutamyltransferase increased | 10 (7) | 8 (5) |
| Blood bilirubin increased | 8 (5) | 2 (1) |
| Hepatic enzyme increased | 7 (5) | 5 (3) |
| Liver function test deviated | 3 (2) | 3 (2) |