Multivariate analyses of the impact of allele-level HLA typing on overall survival according to number and loci of allelic HLA-mismatches
| Predictors of overall survival . | Multivariate HR (95% CI) . | P value . |
|---|---|---|
| 3 vs 0-2 MM∗ | 0.97 (0.64-1.45) | .87 |
| 4 vs 0-2 MM∗ | 1.26 (0.86-1.85) | .24 |
| ≥5 vs 0-2 MM∗ | 1.33 (0.90-1.98) | .15 |
| ≥4 vs 0-3 MM∗ | 1.32 (1.06-1.66) | .015 |
| Winning unit with 3 vs 0-2 MM† | 0.92 (0.62-1.37) | .69 |
| Winning unit with 4 vs 0-2 MM† | 1.31 (0.89-1.94) | .17 |
| Winning unit with ≥5 vs 0-2 MM† | 1.39 (0.86-2.25) | .18 |
| Winning unit with ≥4 vs 0-3 MM‡ | 1.43 (1.06-1.92) | .019 |
| MM at HLA-A, B or C MM and DR (class I and II) vs HLA-DRB1 MM (class I only) irrespective of the number of MM§ | 1.08 (0.86-1.36) | .52 |
| MM at HLA-A, B or C MM and DR (class I and II) vs HLA-DRB1 MM (class I only) in patients with ≥4 MM‖ | 1.10 (0.85-1.41) | .48 |
| Predictors of overall survival . | Multivariate HR (95% CI) . | P value . |
|---|---|---|
| 3 vs 0-2 MM∗ | 0.97 (0.64-1.45) | .87 |
| 4 vs 0-2 MM∗ | 1.26 (0.86-1.85) | .24 |
| ≥5 vs 0-2 MM∗ | 1.33 (0.90-1.98) | .15 |
| ≥4 vs 0-3 MM∗ | 1.32 (1.06-1.66) | .015 |
| Winning unit with 3 vs 0-2 MM† | 0.92 (0.62-1.37) | .69 |
| Winning unit with 4 vs 0-2 MM† | 1.31 (0.89-1.94) | .17 |
| Winning unit with ≥5 vs 0-2 MM† | 1.39 (0.86-2.25) | .18 |
| Winning unit with ≥4 vs 0-3 MM‡ | 1.43 (1.06-1.92) | .019 |
| MM at HLA-A, B or C MM and DR (class I and II) vs HLA-DRB1 MM (class I only) irrespective of the number of MM§ | 1.08 (0.86-1.36) | .52 |
| MM at HLA-A, B or C MM and DR (class I and II) vs HLA-DRB1 MM (class I only) in patients with ≥4 MM‖ | 1.10 (0.85-1.41) | .48 |
N = 596. Adjusted for ATG use (HR, 1.50; P = .001) and TNC > 3.5 × 107/kg (HR, 0.56; P = .001).
N = 370. Adjusted for age >45 years (HR, 1.51; P = .01), high-risk vs low-risk disease (HR, 3.82; P = .004) and TNC >3.5 × 107/kg (HR, 0.48; P = .015).
N = 370. Adjusted for age >45 years (HR, 1.49; P = .01), weight >87 kg (HR, 1.58; P = .02), very high-risk vs low-risk disease (HR, 3.64; P = .005) and TNC > 3.5 × 107/kg (HR, 0.53; P = .03).
N = 563. Adjusted for ATG use (HR, 1.57; P < .001), age >45 years (HR, 1.43; P = .002), weight >87 kg (HR, 1.42; P = .02) and TNC >3.5 × 107/kg (HR, 0.58; P = .003).
N = 434. Adjusted for age >45 years (HR, 1.47; P = .003), weight >87 kg (HR, 1.47; P = .02) and TNC >3.5 × 107/kg (HR, 0.59; P = .01).