Baseline characteristics
| Characteristic . | RARG fusions number (% or range) . | Typical APL number (% or range) . | P . |
|---|---|---|---|
| No. of patients | 34 | 100 | |
| Age (y) median (range) | 42 (1-67) | 37 (17-74) | .7590 |
| Male sex (%) | 20 (59) | 54 s (54) | .2390 |
| Clinical presentation | n = 33 | n = 90 | |
| Bleeding | 18 (55) | 70 (78) | .0114 |
| Fever | 18 (55) | 33 (30) | .0745 |
| Blood tests (range) | n = 33 | n = 94 | |
| White blood cell count (×109/L) | 6.8 (0.2-139) | 3.63 (0.3-102.38) | .2349 |
| Hemoglobin (×g/L) | 81 (42-127) | 91 (41-139) | .0170 |
| Platelet count (×109/L) | 57.5 (7-204) | 28 (3-184) | .0004 |
| PT (s) | 14 (11.5-18.1) | 15.85(10.2-27.1) | .0061 |
| APTT (s) | 30.7 (19.5-43.1) | 35.85 (22.1-55.4) | .0023 |
| Fibrinogen (mg/dL) | 134 (40-540) | 146 (40-595) | .9417 |
| D-dimer (ug/L) | 7090 (571-94390) | 15400 (930-182310) | < .0001 |
| Bone marrow | |||
| Morphology | n = 33 | n = 79 | |
| APL-like cells (range) | 87 (27-100) | 82 (46-97) | .1204 |
| Hypergranular (%) | 25 (73.5) | 71 (90) | .0258 |
| Hypogranular (%) | 9 (26.5) | 8 (10) | .0258 |
| Auer body (%) | 14 (41) | 74 (94) | .0006 |
| Cytogenetics (%) | |||
| Normal karyotype | 14 (41) | — | |
| t(11;12)(p15;q13) | 9 (27) | — | |
| t(12;13)(q13;q13) | 1 (3) | — | |
| t(12;15)(q13;q22) | 1 (3) | — | |
| t(12;19)(q13;p13.1) | 1 (3) | — | |
| others karyotype | 7 (21) | — | |
| Not available | 1 (3) | — | |
| Partner fusion gene (%) | |||
| CPSF6 | 14 (41) | — | |
| NUP98 | 11 (32) | — | |
| HNRNPc | 6 (18) | — | |
| HNRNPm | 1 (3) | — | |
| PML | 1 (3) | — | |
| NPM1 | 1 (3) | — | |
| Sanz risk stratification (%) | |||
| Nonhigh-risk | 21 of 34 (62) | 63 of 94 (67) | .5802 |
| high-risk | 13 of 34 (38) | 31 of 94 (33) | .5802 |
| Characteristic . | RARG fusions number (% or range) . | Typical APL number (% or range) . | P . |
|---|---|---|---|
| No. of patients | 34 | 100 | |
| Age (y) median (range) | 42 (1-67) | 37 (17-74) | .7590 |
| Male sex (%) | 20 (59) | 54 s (54) | .2390 |
| Clinical presentation | n = 33 | n = 90 | |
| Bleeding | 18 (55) | 70 (78) | .0114 |
| Fever | 18 (55) | 33 (30) | .0745 |
| Blood tests (range) | n = 33 | n = 94 | |
| White blood cell count (×109/L) | 6.8 (0.2-139) | 3.63 (0.3-102.38) | .2349 |
| Hemoglobin (×g/L) | 81 (42-127) | 91 (41-139) | .0170 |
| Platelet count (×109/L) | 57.5 (7-204) | 28 (3-184) | .0004 |
| PT (s) | 14 (11.5-18.1) | 15.85(10.2-27.1) | .0061 |
| APTT (s) | 30.7 (19.5-43.1) | 35.85 (22.1-55.4) | .0023 |
| Fibrinogen (mg/dL) | 134 (40-540) | 146 (40-595) | .9417 |
| D-dimer (ug/L) | 7090 (571-94390) | 15400 (930-182310) | < .0001 |
| Bone marrow | |||
| Morphology | n = 33 | n = 79 | |
| APL-like cells (range) | 87 (27-100) | 82 (46-97) | .1204 |
| Hypergranular (%) | 25 (73.5) | 71 (90) | .0258 |
| Hypogranular (%) | 9 (26.5) | 8 (10) | .0258 |
| Auer body (%) | 14 (41) | 74 (94) | .0006 |
| Cytogenetics (%) | |||
| Normal karyotype | 14 (41) | — | |
| t(11;12)(p15;q13) | 9 (27) | — | |
| t(12;13)(q13;q13) | 1 (3) | — | |
| t(12;15)(q13;q22) | 1 (3) | — | |
| t(12;19)(q13;p13.1) | 1 (3) | — | |
| others karyotype | 7 (21) | — | |
| Not available | 1 (3) | — | |
| Partner fusion gene (%) | |||
| CPSF6 | 14 (41) | — | |
| NUP98 | 11 (32) | — | |
| HNRNPc | 6 (18) | — | |
| HNRNPm | 1 (3) | — | |
| PML | 1 (3) | — | |
| NPM1 | 1 (3) | — | |
| Sanz risk stratification (%) | |||
| Nonhigh-risk | 21 of 34 (62) | 63 of 94 (67) | .5802 |
| high-risk | 13 of 34 (38) | 31 of 94 (33) | .5802 |
APTT, partial thromboplastin time; PT, prothrombin time.