Table 3. Additive KIR/KIR-ligand models... | American Society of Hematology

Table 3.

Additive KIR/KIR-ligand models

Classifier	No. of respective patients with AML (No. of total patients with AML)	Portion of respective patients with AML	No. of respective control subjects (No. of total control subjects)	Portion of respective control subjects	P	Adjusted P
Inhibitory KIR/KIR-ligand count considering KIR3DL1/HLA-Bw4 (Boelen et al), overall χ² test P = .042
Functional iKIR count (cutoff ≤ 1)	229 (1 676)	0.137	7 743 (49 898)	0.155	.042
Functional iKIR count (cutoff > 1)	1 447 (1 676)	0.863	42 155 (49 898)	0.845
Inhibitory KIR/KIR-ligand score considering KIR3DL1/HLA-Bw4 (Boelen et al), overall χ² test P = .079
Inhibitory score (cutoff ≤ 1.75)	674 (1 676)	0.402	21 157 (49 898)	0.424	.079
Inhibitory score (cutoff > 1.75)	1 002 (1 676)	0.598	28 741 (49 898)	0.576
Inhibitory and activating KIR/KIR-ligand matches∗ (Rafei et al), overall χ² test P = .164
Inhibitory and activating favorable	1 087 (1 581)	0.688	29 695 (42 171)	0.704	.164
Inhibitory and activating unfavorable†	494 (1 581)	0.312	12 476 (42 171)	0.296
Nonweighted additive inhibitory/missing-ligand KIR score (Krieger et al), overall χ² test P = .206
2	2 (1 584)	0.001	61 (42 177)	0.001	1.000	1.000
3	73 (1 584)	0.046	2 483 (42 177)	0.059	.039	.158
4	870 (1 584)	0.550	22 780 (42 177)	0.540	.440	1.000
5	636 (1 584)	0.402	16 853 (42 177)	0.400	.850	1.000

Classifier	No. of respective patients with AML (No. of total patients with AML)	Portion of respective patients with AML	No. of respective control subjects (No. of total control subjects)	Portion of respective control subjects	P	Adjusted P
Inhibitory KIR/KIR-ligand count considering KIR3DL1/HLA-Bw4 (Boelen et al), overall χ² test P = .042
Functional iKIR count (cutoff ≤ 1)	229 (1 676)	0.137	7 743 (49 898)	0.155	.042
Functional iKIR count (cutoff > 1)	1 447 (1 676)	0.863	42 155 (49 898)	0.845
Inhibitory KIR/KIR-ligand score considering KIR3DL1/HLA-Bw4 (Boelen et al), overall χ² test P = .079
Inhibitory score (cutoff ≤ 1.75)	674 (1 676)	0.402	21 157 (49 898)	0.424	.079
Inhibitory score (cutoff > 1.75)	1 002 (1 676)	0.598	28 741 (49 898)	0.576
Inhibitory and activating KIR/KIR-ligand matches∗ (Rafei et al), overall χ² test P = .164
Inhibitory and activating favorable	1 087 (1 581)	0.688	29 695 (42 171)	0.704	.164
Inhibitory and activating unfavorable†	494 (1 581)	0.312	12 476 (42 171)	0.296
Nonweighted additive inhibitory/missing-ligand KIR score (Krieger et al), overall χ² test P = .206
2	2 (1 584)	0.001	61 (42 177)	0.001	1.000	1.000
3	73 (1 584)	0.046	2 483 (42 177)	0.059	.039	.158
4	870 (1 584)	0.550	22 780 (42 177)	0.540	.440	1.000
5	636 (1 584)	0.402	16 853 (42 177)	0.400	.850	1.000

∗

The truncated version of KIR2DS4 is not considered as an activating KIR.

†

≥3 inhibitory KIR/KIR-ligand matches and no activating KIR/KIR-ligand match. Numbers of cases evaluated for each test vary because of remaining ambiguities and are reported in parentheses.

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