Patient baseline characteristics
| Characteristic . | IA cohort (n = 385) . | LOW + VEN cohort (n = 250) . | P value . |
|---|---|---|---|
| Age, y | 52.8 (17.1-77.7) | 71.6 (25.6-89.1) | < .001 |
| Age, ≥60 y | 58 (15.1) | 239 (95.6) | < .001 |
| Sex | .004 | ||
| Male | 178 (46.2) | 145 (58) | |
| Female | 207 (53.8) | 105 (42) | |
| Best response | < .001 | ||
| CR | 344 (89.4) | 190 (76) | |
| CRi | 34 (8.8) | 42 (16.8) | |
| MLFS | 7 (1.8) | 18 (7.2) | |
| MRD status | .004 | ||
| Negative | 275 (71.4) | 151 (60.4) | |
| Positive | 110 (28.6) | 99 (39.6) | |
| ELN 2017 risk | < .001 | ||
| Favorable | 106 (27.5) | 55 (22.0) | |
| Intermediate | 140 (36.4) | 50 (20.0) | |
| Adverse | 129 (33.5) | 144 (57.6) | |
| Not available | 10 (2.6) | 1 (0.4) | |
| Cytogenetics | |||
| Diploid | 201 (52.2) | 106 (42.4) | .016 |
| Other intermediate | 62 (16.1) | 38 (15.2) | .760 |
| 11q23 | 23 (6) | 11 (4.4) | .389 |
| t(6;9) | 6 (1.6) | 2 (0.8) | .490 |
| inv(3) | 5 (1.3) | 5 (2) | .488 |
| −5/5q– | 28 (7.3) | 48 (19.2) | < .001 |
| −7/7q– | 28 (7.3) | 42 (16.8) | < .001 |
| −17/17p– | 21 (5.5) | 31 (12.4) | .002 |
| Complex | 63 (16.4) | 73 (29.2) | < .001 |
| Characteristic . | IA cohort (n = 385) . | LOW + VEN cohort (n = 250) . | P value . |
|---|---|---|---|
| Age, y | 52.8 (17.1-77.7) | 71.6 (25.6-89.1) | < .001 |
| Age, ≥60 y | 58 (15.1) | 239 (95.6) | < .001 |
| Sex | .004 | ||
| Male | 178 (46.2) | 145 (58) | |
| Female | 207 (53.8) | 105 (42) | |
| Best response | < .001 | ||
| CR | 344 (89.4) | 190 (76) | |
| CRi | 34 (8.8) | 42 (16.8) | |
| MLFS | 7 (1.8) | 18 (7.2) | |
| MRD status | .004 | ||
| Negative | 275 (71.4) | 151 (60.4) | |
| Positive | 110 (28.6) | 99 (39.6) | |
| ELN 2017 risk | < .001 | ||
| Favorable | 106 (27.5) | 55 (22.0) | |
| Intermediate | 140 (36.4) | 50 (20.0) | |
| Adverse | 129 (33.5) | 144 (57.6) | |
| Not available | 10 (2.6) | 1 (0.4) | |
| Cytogenetics | |||
| Diploid | 201 (52.2) | 106 (42.4) | .016 |
| Other intermediate | 62 (16.1) | 38 (15.2) | .760 |
| 11q23 | 23 (6) | 11 (4.4) | .389 |
| t(6;9) | 6 (1.6) | 2 (0.8) | .490 |
| inv(3) | 5 (1.3) | 5 (2) | .488 |
| −5/5q– | 28 (7.3) | 48 (19.2) | < .001 |
| −7/7q– | 28 (7.3) | 42 (16.8) | < .001 |
| −17/17p– | 21 (5.5) | 31 (12.4) | .002 |
| Complex | 63 (16.4) | 73 (29.2) | < .001 |
Data displayed as median (range) or n (%).