Characteristics of 1192 older patients with CML who received BCR-ABL1 TKIs between 2007 and 2017
| . | Overall . | Optimal monitoring . | P . | |
|---|---|---|---|---|
| No . | Yes . | |||
| n (%) . | n (%) . | n (%) . | ||
| Total | 1192 | 652 | 540 | |
| Age at diagnosis (y) | ||||
| 66-69 | 281 (23.6) | 137 (21.0) | 144 (26.7) | < .01 |
| 70-74 | 316 (26.5) | 161 (24.7) | 155 (28.7) | |
| 75-79 | 266 (22.3) | 137 (21.0) | 129 (23.9) | |
| 80-84 | 200 (16.8) | 125 (19.2) | 75 (13.9) | |
| 85-99 | 129 (10.8) | 92 (14.1) | 37 (6.9) | |
| Sex | ||||
| Female | 623 (52.3) | 345 (52.9) | 278 (51.5) | .62 |
| Male | 569 (47.7) | 307 (47.1) | 262 (48.5) | |
| Race | ||||
| Non-Hispanic White | 967 (81.1) | 518 (79.4) | 449 (83.1) | .10 |
| Other | 225 (18.9) | 134 (20.6) | 91 (16.9) | |
| Year of diagnosis | ||||
| 2007-2010 | 289 (24.2) | 201 (30.8) | 88 (16.3) | < .01 |
| 2011-2014 | 508 (42.6) | 266 (40.8) | 242 (44.8) | |
| 2015-2017 | 395 (33.1) | 185 (28.4) | 210 (38.9) | |
| Marital status | ||||
| Married | 431 (36.2) | 232 (35.6) | 199 (36.9) | .75 |
| Unmarried | 635 (53.3) | 348 (53.4) | 287 (53.1) | |
| Unknown | 126 (10.6) | 72 (11.0) | 54 (10.0) | |
| Region | ||||
| Northeast | 475 (39.8) | 250 (38.3) | 225 (41.7) | .70 |
| West | 126 (10.6) | 71 (10.9) | 55 (10.2) | |
| Midwest | 249 (20.9) | 138 (21.2) | 111 (20.6) | |
| South | 342 (28.7) | 193 (29.6) | 149 (27.6) | |
| Modified Elixhauser comorbidity score | ||||
| 0 | 444 (37.2) | 237 (36.3) | 207 (38.3) | .49 |
| 1 | 356 (29.9) | 191 (29.3) | 165 (30.6) | |
| ≥2 | 392 (32.9) | 224 (34.4) | 168 (31.1) | |
| Previous cancer diagnosis | ||||
| No | 848 (71.1) | 467 (71.6) | 381 (70.6) | .68 |
| Yes | 344 (28.9) | 185 (28.4) | 159 (29.4) | |
| Previous CVDs | ||||
| No | 846 (71.0) | 462 (70.9) | 384 (71.1) | .92 |
| Yes | 346 (29.0) | 190 (29.1) | 156 (28.9) | |
| Previous pulmonary diseases | ||||
| No | 1143 (95.9) | 622 (95.4) | 521 (96.5) | .35 |
| Yes | 49 (4.1) | 30 (4.6) | 19 (3.5) | |
| CVD risk factors∗ | ||||
| No | 170 (14.3) | 89 (13.7) | 81 (15.0) | .51 |
| Yes | 1022 (85.7) | 563 (86.3) | 459 (85.0) | |
| Low-income subsidy | ||||
| No | 798 (66.9) | 402 (61.7) | 396 (73.3) | < .01 |
| Yes | 394 (33.1) | 250 (38.3) | 144 (26.7) | |
| Yost index | ||||
| Fifth quintile (highest SES) | 348 (29.2) | 176 (27.0) | 172 (31.9) | .01 |
| Fourth quintile | 243 (20.4) | 136 (20.9) | 107 (19.8) | |
| Third quintile | 197 (16.5) | 107 (16.4) | 90 (16.7) | |
| Second quintile | 184 (15.4) | 97 (14.9) | 87 (16.1) | |
| First quintile (lowest SES) | 179 (15.0) | 119 (18.3) | 60 (11.1) | |
| Unknown | 41 (3.4) | 17 (2.6) | 24 (4.4) | |
| Influenza vaccine within 12 mo before diagnosis | ||||
| No | 418 (35.1) | 248 (38.0) | 170 (31.5) | .02 |
| Yes | 774 (64.9) | 404 (62.0) | 370 (68.5) | |
| . | Overall . | Optimal monitoring . | P . | |
|---|---|---|---|---|
| No . | Yes . | |||
| n (%) . | n (%) . | n (%) . | ||
| Total | 1192 | 652 | 540 | |
| Age at diagnosis (y) | ||||
| 66-69 | 281 (23.6) | 137 (21.0) | 144 (26.7) | < .01 |
| 70-74 | 316 (26.5) | 161 (24.7) | 155 (28.7) | |
| 75-79 | 266 (22.3) | 137 (21.0) | 129 (23.9) | |
| 80-84 | 200 (16.8) | 125 (19.2) | 75 (13.9) | |
| 85-99 | 129 (10.8) | 92 (14.1) | 37 (6.9) | |
| Sex | ||||
| Female | 623 (52.3) | 345 (52.9) | 278 (51.5) | .62 |
| Male | 569 (47.7) | 307 (47.1) | 262 (48.5) | |
| Race | ||||
| Non-Hispanic White | 967 (81.1) | 518 (79.4) | 449 (83.1) | .10 |
| Other | 225 (18.9) | 134 (20.6) | 91 (16.9) | |
| Year of diagnosis | ||||
| 2007-2010 | 289 (24.2) | 201 (30.8) | 88 (16.3) | < .01 |
| 2011-2014 | 508 (42.6) | 266 (40.8) | 242 (44.8) | |
| 2015-2017 | 395 (33.1) | 185 (28.4) | 210 (38.9) | |
| Marital status | ||||
| Married | 431 (36.2) | 232 (35.6) | 199 (36.9) | .75 |
| Unmarried | 635 (53.3) | 348 (53.4) | 287 (53.1) | |
| Unknown | 126 (10.6) | 72 (11.0) | 54 (10.0) | |
| Region | ||||
| Northeast | 475 (39.8) | 250 (38.3) | 225 (41.7) | .70 |
| West | 126 (10.6) | 71 (10.9) | 55 (10.2) | |
| Midwest | 249 (20.9) | 138 (21.2) | 111 (20.6) | |
| South | 342 (28.7) | 193 (29.6) | 149 (27.6) | |
| Modified Elixhauser comorbidity score | ||||
| 0 | 444 (37.2) | 237 (36.3) | 207 (38.3) | .49 |
| 1 | 356 (29.9) | 191 (29.3) | 165 (30.6) | |
| ≥2 | 392 (32.9) | 224 (34.4) | 168 (31.1) | |
| Previous cancer diagnosis | ||||
| No | 848 (71.1) | 467 (71.6) | 381 (70.6) | .68 |
| Yes | 344 (28.9) | 185 (28.4) | 159 (29.4) | |
| Previous CVDs | ||||
| No | 846 (71.0) | 462 (70.9) | 384 (71.1) | .92 |
| Yes | 346 (29.0) | 190 (29.1) | 156 (28.9) | |
| Previous pulmonary diseases | ||||
| No | 1143 (95.9) | 622 (95.4) | 521 (96.5) | .35 |
| Yes | 49 (4.1) | 30 (4.6) | 19 (3.5) | |
| CVD risk factors∗ | ||||
| No | 170 (14.3) | 89 (13.7) | 81 (15.0) | .51 |
| Yes | 1022 (85.7) | 563 (86.3) | 459 (85.0) | |
| Low-income subsidy | ||||
| No | 798 (66.9) | 402 (61.7) | 396 (73.3) | < .01 |
| Yes | 394 (33.1) | 250 (38.3) | 144 (26.7) | |
| Yost index | ||||
| Fifth quintile (highest SES) | 348 (29.2) | 176 (27.0) | 172 (31.9) | .01 |
| Fourth quintile | 243 (20.4) | 136 (20.9) | 107 (19.8) | |
| Third quintile | 197 (16.5) | 107 (16.4) | 90 (16.7) | |
| Second quintile | 184 (15.4) | 97 (14.9) | 87 (16.1) | |
| First quintile (lowest SES) | 179 (15.0) | 119 (18.3) | 60 (11.1) | |
| Unknown | 41 (3.4) | 17 (2.6) | 24 (4.4) | |
| Influenza vaccine within 12 mo before diagnosis | ||||
| No | 418 (35.1) | 248 (38.0) | 170 (31.5) | .02 |
| Yes | 774 (64.9) | 404 (62.0) | 370 (68.5) | |
CVD risk factors included hypertension, hyperlipidemia, diabetes mellitus, and tobacco use.