Determinants of low HRQoL - multivariable analyses based on multiple imputation
| Independent variable . | Multivariable model EQ-5D index N = 5522 observations; Brier score: 0.20; ROC area: 0.76 . | Multivariable model VAS score N = 5522 observations; Brier score: 0.18; ROC area: 0.80 . | ||
|---|---|---|---|---|
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Sociodemographic variables | ||||
| Age (vs <60) | ||||
| 60-75 | 1.33 (1.01-1.75) | .045 | 0.96 (0.72-1.26) | .758 |
| ≥75 | 1.84 (1.39-2.45) | .000 | 1.44 (1.07-1.92) | .015 |
| Sex (female) | 1.70 (1.43-2.03) | .000 | 1.22 (1.02-1.46) | .032 |
| Clinical variables | ||||
| Transfusion dependence∗ | 1.34 (0.92-1.95) | .127 | 1.53 (1.03-2.29) | .037 |
| Hb ≤ 10 g/dL | 1.14 (0.97-1.36) | .120 | 1.34 (1.12-1.61) | .001 |
| Transfusion dependence AND Hb ≤ 10 | 0.75 (0.50-1.12) | .161 | 0.79 (0.51-1.23) | .303 |
| SF, μg/L (vs ≤300) | ||||
| 300-1000 | 1.10 (0.92-1.32) | .306 | 1.14 (0.95-1.37) | .167 |
| ≥1000 | 1.41 (1.06-1.87) | .018 | 1.37 (1.02-1.84) | .034 |
| Neutrophils, ×109/L (continuous) | 1.02 (1.00-1.05) | .098 | 1.01 (0.99-1.04) | .275 |
| Treatments | ||||
| ESA (1 = yes, 0 = no) | 1.04 (0.86-1.27) | .672 | 1.13 (0.92-1.39) | .229 |
| ESA AND transfusion dependence | 0.91 (0.63-1.29) | .586 | 0.72 (0.50-1.05) | .092 |
| Use of iron chelators | 1.15 (0.77-1.73) | .487 | 1.18 (0.78-1.79) | .424 |
| Patient-related variables | ||||
| KPS (per 10 units) | 0.62 (0.58-0.67) | .000 | 0.53 (0.49-0.57) | .000 |
| MDS-CI (continuous) | 1.11 (1.02-1.20) | .011 | 1.14 (1.05-1.25) | .002 |
| BMI, kg/m2 (vs 23-29.9) | ||||
| Underweight <23 | 0.97 (0.78-1.21) | .772 | 1.14 (0.91-1.42) | .249 |
| Overweight ≥30 | 1.21 (0.99-1.50) | .068 | 1.26 (1.02-1.57) | .033 |
| Independent variable . | Multivariable model EQ-5D index N = 5522 observations; Brier score: 0.20; ROC area: 0.76 . | Multivariable model VAS score N = 5522 observations; Brier score: 0.18; ROC area: 0.80 . | ||
|---|---|---|---|---|
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Sociodemographic variables | ||||
| Age (vs <60) | ||||
| 60-75 | 1.33 (1.01-1.75) | .045 | 0.96 (0.72-1.26) | .758 |
| ≥75 | 1.84 (1.39-2.45) | .000 | 1.44 (1.07-1.92) | .015 |
| Sex (female) | 1.70 (1.43-2.03) | .000 | 1.22 (1.02-1.46) | .032 |
| Clinical variables | ||||
| Transfusion dependence∗ | 1.34 (0.92-1.95) | .127 | 1.53 (1.03-2.29) | .037 |
| Hb ≤ 10 g/dL | 1.14 (0.97-1.36) | .120 | 1.34 (1.12-1.61) | .001 |
| Transfusion dependence AND Hb ≤ 10 | 0.75 (0.50-1.12) | .161 | 0.79 (0.51-1.23) | .303 |
| SF, μg/L (vs ≤300) | ||||
| 300-1000 | 1.10 (0.92-1.32) | .306 | 1.14 (0.95-1.37) | .167 |
| ≥1000 | 1.41 (1.06-1.87) | .018 | 1.37 (1.02-1.84) | .034 |
| Neutrophils, ×109/L (continuous) | 1.02 (1.00-1.05) | .098 | 1.01 (0.99-1.04) | .275 |
| Treatments | ||||
| ESA (1 = yes, 0 = no) | 1.04 (0.86-1.27) | .672 | 1.13 (0.92-1.39) | .229 |
| ESA AND transfusion dependence | 0.91 (0.63-1.29) | .586 | 0.72 (0.50-1.05) | .092 |
| Use of iron chelators | 1.15 (0.77-1.73) | .487 | 1.18 (0.78-1.79) | .424 |
| Patient-related variables | ||||
| KPS (per 10 units) | 0.62 (0.58-0.67) | .000 | 0.53 (0.49-0.57) | .000 |
| MDS-CI (continuous) | 1.11 (1.02-1.20) | .011 | 1.14 (1.05-1.25) | .002 |
| BMI, kg/m2 (vs 23-29.9) | ||||
| Underweight <23 | 0.97 (0.78-1.21) | .772 | 1.14 (0.91-1.42) | .249 |
| Overweight ≥30 | 1.21 (0.99-1.50) | .068 | 1.26 (1.02-1.57) | .033 |
Bold P values < .05.
EQ-5D, EQ-5D 3-levels questionnaire; ROC, receiver operating characteristic curve; VAS, EQ-5D VAS.
At least 1 unit RBC transfusion for a surveillance time of 8 weeks before the HRQoL assessment.