Outcomes for MICB-52Asp patients when donors have 1 favorable feature
| Donor characteristic . | No. . | Mortality HR (95% CI; P value) . | Relapse HR (95% CI; P value) . | DFS HR (95% CI; P value) . |
|---|---|---|---|---|
| No NKG2D-72Thr donor | ||||
| MICA-STR match | 448 | 1.0 | 1.0 | 1.0 |
| MICA-STR mismatch | 557 | 0.77 (0.62-0.94; .01) | 0.91 (0.72-1.13; .38) | 0.84 (0.70-1.02; .07) |
| No MICA-STR–mismatched donor | ||||
| NKG2D-72Ala | 286 | 1.0 | 1.0 | 1.0 |
| NKG2D-72AlaThr | 162 | 1.32 (0.97-1.79; .08) | 1.11 (0.79-1.57; .55) | 1.13 (0.85-1.50; .39) |
| NKG2D-72Thr | 30 | 0.70 (0.33-1.47; .35) | 0.69 (0.29-1.64; .40) | 0.62 (0.30-1.30; .21) |
| Donor characteristic . | No. . | Mortality HR (95% CI; P value) . | Relapse HR (95% CI; P value) . | DFS HR (95% CI; P value) . |
|---|---|---|---|---|
| No NKG2D-72Thr donor | ||||
| MICA-STR match | 448 | 1.0 | 1.0 | 1.0 |
| MICA-STR mismatch | 557 | 0.77 (0.62-0.94; .01) | 0.91 (0.72-1.13; .38) | 0.84 (0.70-1.02; .07) |
| No MICA-STR–mismatched donor | ||||
| NKG2D-72Ala | 286 | 1.0 | 1.0 | 1.0 |
| NKG2D-72AlaThr | 162 | 1.32 (0.97-1.79; .08) | 1.11 (0.79-1.57; .55) | 1.13 (0.85-1.50; .39) |
| NKG2D-72Thr | 30 | 0.70 (0.33-1.47; .35) | 0.69 (0.29-1.64; .40) | 0.62 (0.30-1.30; .21) |
Models show HRs associated with MICA-STR mismatching relative to matching when no NKG2D-72Thr donor is available (ie, donors are NKG2D-72Ala or AlaThr).
Models show HRs associated with donor NKG2D-72 genotype when no MICA-STR–mismatched donor is available (ie, donors are MICA-STR–matched)
DFS, disease-free survival.